Early Metabolic Changes With Thiazide or Beta Blocker Therapy for Essential Hypertension

Summary

Can the oral glucose tolerance test detect changes after 4 weeks treatment with thiazide diuretics or beta blockers or combination of the two?

Timeline

Start

2006-09

Primary completion

—

Completion

—

Outcome

Met primary endpoint

paper For similar blood pressure reductions, there were opposite changes in glucose between the 2 diuretics (P<0.0001). PMID 22493073 ↗

paper In 2 crossover studies, 4 weeks of treatment with a thiazide diuretic impaired glucose tolerance. PMID 22493073 ↗

Publications

• Stears AJ, Woods SH, Watts MM, Burton TJ, Graggaber J, Mir FA, Brown MJ. A double-blind, placebo-controlled, crossover trial comparing the effects of amiloride and hydrochlorothiazide on glucose tolerance in patients with essential hypertension. Hypertension. 2012 May;59(5):934-42. doi: 10.1161/HYPERTENSIONAHA.111.189381. Epub 2012 Apr 9.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Atenolol	Other / unclassified	50 mg	—
Subject	Atenolol	Other / unclassified	100 mg	—
Subject	Bendroflumethiazide	Small molecule	5 mg	—
Subject	Bendroflumethiazide	Small molecule	10 mg	—

Indications