drugset / Trial / NCT05585125
A Preliminary Study for INFORMED
Phase 4
Enrolling by invitation
20 enrolled
Weill Medical College of Cornell University
National Institute on Aging (NIA) · collab
RandomizedCrossoverOpen-labelOther
Summary
Investigators will determine whether N-of-1 trials, as a pragmatic, participant-centered approach to medication optimization that can overcome key barriers of deprescribing, can lead to increased participant confidence regarding their preference to continue or discontinue beta-blockers in older adults with Heart Failure with Preserved Ejection Fraction (HFpEF).
Timeline
- Start
- 2024-02-07
- Primary completion
- 2026-07
- Completion
- 2026-07
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Atenolol | Other / unclassified | — | — |
| Subject | Bisoprolol | Other / unclassified | — | — |
| Subject | Carvedilol | Other / unclassified | — | — |
| Subject | Labetalol | Small molecule | — | — |
| Subject | Metoprolol | Other / unclassified | — | — |
| Subject | Nadolol | Unknown | — | — |
| Subject | Nebivolol | Other / unclassified | — | — |
| Subject | Pindolol | Small molecule | — | — |
| Subject | Propranolol | Small molecule | — | — |
| Subject | acebutolol | Small molecule | — | — |
| Subject | betaxolol | Small molecule | — | — |
| Subject | penbutolol | Small molecule | — | — |