Drugs / betaxolol
betaxolol
also known as
ALO 1401-02 · ALO-140102 FREE BASE · betaxolol HCl · betaxolol hydrochloride · Betaxolol hydrochloride component of betoptic pilo · Betaxolol hydrochloride component of kerledex · Betoptic · BETOPTIC S · +6 more
Small molecule targets ADRB1 via inhibition
Regulatory milestones approvals, filings & regulatory actions · 2 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Label expansion | US (FDA) | BETOPTIC S | — | 2007-06-08 | fda.gov ↗ |
| Approved | US (FDA) | BETOPTIC | — | 1985-08-30 | fda.gov ↗ |
Trials 5
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 11 trial | ||||||
| Phase 1 | NCT01660620 | Apr → Nov 2011 | — | Smith-Kettlewell Eye Research Institute | Completed | No outcome recorded |
| Phase 32 trials | ||||||
| Phase 3 | NCT00061542 | Jan 2003 → Nov 2006 | glaucoma, ocular hypertension | Alcon Research | Completed | No outcome recorded |
| Phase 3 | NCT00000132 | Oct 1992 → ? | open-angle glaucoma | National Eye Institute (NEI) | Unknown | No outcome recorded |
| Phase 42 trials | ||||||
| Phase 4 | NCT05585125 | Feb 2024 → Jul 2026 overdue | diastolic heart failure | Weill Medical College of Cornell University | Enrolling by invitation | No outcome recorded |
| Phase 4 | NCT05019027 | Jan 2024 → Mar 2026 overdue | amyloidosis, heart disorder | Weill Medical College of Cornell University | Enrolling by invitation | No outcome recorded |
| Comparator or background therapy4 trials | ||||||
| Phase 3 | NCT02617459 Comparator | Jan 2019 → Jul 2021 | ocular hypertension, open-angle glaucoma | Zhaoke (Guangzhou) Ophthalmology Pharmaceutical Ltd. | Completed | No outcome recorded |
| Phase 4 | NCT04757584 Comparator | Apr 2021 → Apr 2023 | diastolic heart failure | Weill Medical College of Cornell University | Completed | No outcome recorded |
| Phase 4 | NCT04767061 Comparator | Apr 2021 → Apr 2022 | diastolic heart failure | Weill Medical College of Cornell University | Completed | No outcome recorded |
| — | NCT00684489 Comparator | Sep 2003 → Mar 2005 | essential hypertension | Medical University of South Carolina | Completed | No outcome recorded |
Evidence & citations 19 cited values
Every value below carries the sentence it was read from. 12 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | betaxolol | “Other names:
acebutolol, atenolol, betaxolol, bisoprolol, carvedilol, labetalol, metoprolol, metoprolol succinate, metoprolol tartrate, nadolol, nebivolol, propranolol,...” NCT05585125 ↗8“Other Names: * acebutolol * atenolol * betaxolol * bisoprolol * carvedilol * labetalol * metoprolol succinate * metoprolol tartrate * nadolol * nebivolol * penbutolol *...” NCT05019027 ↗ “spironolactone, atenolol, betaxolol, bisoprolol, metoprolol, nadolol” NCT00684489 ↗ “betaxolol” NCT04767061 ↗ “betaxolol” NCT04757584 ↗ |
| Known as | ALO 1401-02 | ChEMBL registry synonym — accepted as the source's own label CHEMBL423 ↗ |
| Known as | ALO-140102 FREE BASE | ChEMBL registry synonym — accepted as the source's own label CHEMBL423 ↗ |
| Known as | betaxolol HCl | “BETOPTIC S (betaxolol HCl)” NCT00061542 ↗ |
| Known as | betaxolol hydrochloride | “betaxolol hydrochloride ophthalmic suspension 0.25% (betaxolol)” PMID 19683191 ↗ Aug 2009 |
| Known as | Betaxolol hydrochloride component of betoptic pilo | ChEMBL registry synonym — accepted as the source's own label CHEMBL423 ↗ |
| Known as | Betaxolol hydrochloride component of kerledex | ChEMBL registry synonym — accepted as the source's own label CHEMBL423 ↗ |
| Known as | Betoptic | ChEMBL registry synonym — accepted as the source's own label CHEMBL423 ↗ |
| Known as | BETOPTIC S | “BETOPTIC S (betaxolol HCl)” NCT00061542 ↗ |
| Known as | Betoptic susp | ChEMBL registry synonym — accepted as the source's own label CHEMBL423 ↗ |
| Known as | Kerledex | ChEMBL registry synonym — accepted as the source's own label CHEMBL423 ↗ |
| Known as | Kerlone | ChEMBL registry synonym — accepted as the source's own label CHEMBL423 ↗ |
| Known as | NSC-760048 | ChEMBL registry synonym — accepted as the source's own label CHEMBL423 ↗ |
| Known as | SL 75.212-10 | ChEMBL registry synonym — accepted as the source's own label CHEMBL423 ↗ |
| Known as | SL-7521210 FREE BASE | ChEMBL registry synonym — accepted as the source's own label CHEMBL423 ↗ |
| Action | Inhibit | “Beta-1 adrenergic receptor antagonist” CHEMBL423 ↗ |
| Modality | Small molecule | — CHEMBL423 ↗ |
| Route | Topical | “topical betaxolol hydrochloride” PMID 21843876 ↗ Aug 2011 |
| Target | ADRB1 | “Beta-1 adrenergic receptor antagonist” CHEMBL423 ↗ |