drugset / Trial / NCT04757584
Pilot Deprescribing N-of-1 Trials for Beta-blockers in HFpEF
Phase 4
Completed
9 enrolled
Weill Medical College of Cornell University
National Institute on Aging (NIA) · collab
RandomizedCrossoverOpen-labelOther
Summary
In this study, we will test the feasibility of N-of-1 trials for deprescribing beta-blockers in patients with Heart Failure with Preserved Ejection Fraction. To achieve this objective we will conduct 16 4-period N-of-1 trials (on vs. off) and subsequently interview participants to better understand feasibility and pragmatism. The N-of-1 trials will be iteratively refined in real-time based on this feedback.
Timeline
- Start
- 2021-04-01
- Primary completion
- 2023-04-28
- Completion
- 2023-04-28
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Atenolol | Other / unclassified | — | — |
| Comparator | Bisoprolol | Other / unclassified | — | — |
| Comparator | Carvedilol | Other / unclassified | — | — |
| Comparator | Labetalol | Small molecule | — | — |
| Comparator | Metoprolol | Other / unclassified | — | — |
| Comparator | Nadolol | Unknown | — | — |
| Comparator | Nebivolol | Other / unclassified | — | — |
| Comparator | Pindolol | Small molecule | — | — |
| Comparator | Propranolol | Small molecule | — | — |
| Comparator | acebutolol | Small molecule | — | — |
| Comparator | betaxolol | Small molecule | — | — |
| Comparator | penbutolol | Small molecule | — | — |
| Comparator | sotalol | Small molecule | — | — |