Drugs / penbutolol
penbutolol
also known as
(-)-isopenbutolol · (s)-penbutolol · Betapressin · HOE 39-893D · HOE 893D · Levatol · NSC-760043 · PENBUTOLOL SULFATE · +1 more
Small molecule targets ADRB1, ADRB2 via inhibition
Regulatory milestones approvals, filings & regulatory actions · 1 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Approved | US (FDA) | LEVATOL | — | 1987-12-30 | fda.gov ↗ |
Trials 2
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 42 trials | ||||||
| Phase 4 | NCT05585125 | Feb 2024 → Jul 2026 overdue | diastolic heart failure | Weill Medical College of Cornell University | Enrolling by invitation | No outcome recorded |
| Phase 4 | NCT05019027 | Jan 2024 → Mar 2026 overdue | amyloidosis, heart disorder | Weill Medical College of Cornell University | Enrolling by invitation | No outcome recorded |
| Comparator or background therapy3 trials | ||||||
| Phase 4 | NCT04757584 Comparator | Apr 2021 → Apr 2023 | diastolic heart failure | Weill Medical College of Cornell University | Completed | No outcome recorded |
| Phase 4 | NCT04767061 Comparator | Apr 2021 → Apr 2022 | diastolic heart failure | Weill Medical College of Cornell University | Completed | No outcome recorded |
| — | NCT00684489 Comparator | Sep 2003 → Mar 2005 | essential hypertension | Medical University of South Carolina | Completed | No outcome recorded |
Evidence & citations 14 cited values
Every value below carries the sentence it was read from. 6 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | penbutolol | “Other names:
acebutolol, atenolol, betaxolol, bisoprolol, carvedilol, labetalol, metoprolol, metoprolol succinate, metoprolol tartrate, nadolol, nebivolol, propranolol,...” NCT05585125 ↗4“Other Names: * acebutolol * atenolol * betaxolol * bisoprolol * carvedilol * labetalol * metoprolol succinate * metoprolol tartrate * nadolol * nebivolol * penbutolol *...” NCT05019027 ↗ “timolol, acebutolol, penbutolol pindolol, carvedilol” NCT00684489 ↗ “penbutolol” NCT04757584 ↗ “penbutolol” NCT04767061 ↗ |
| Known as | (-)-isopenbutolol | ChEMBL registry synonym — accepted as the source's own label CHEMBL1290 ↗ |
| Known as | (s)-penbutolol | ChEMBL registry synonym — accepted as the source's own label CHEMBL1290 ↗ |
| Known as | Betapressin | ChEMBL registry synonym — accepted as the source's own label CHEMBL1290 ↗ |
| Known as | HOE 39-893D | ChEMBL registry synonym — accepted as the source's own label CHEMBL1290 ↗ |
| Known as | HOE 893D | ChEMBL registry synonym — accepted as the source's own label CHEMBL1290 ↗ |
| Known as | Levatol | ChEMBL registry synonym — accepted as the source's own label CHEMBL1290 ↗ |
| Known as | NSC-760043 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1290 ↗ |
| Known as | PENBUTOLOL SULFATE | ChEMBL registry synonym — accepted as the source's own label CHEMBL1290 ↗ |
| Known as | Penbutolol sulphate | ChEMBL registry synonym — accepted as the source's own label CHEMBL1290 ↗ |
| Action | Inhibit | “Beta-2 adrenergic receptor antagonist” CHEMBL1290 ↗1“Beta-1 adrenergic receptor antagonist” CHEMBL1290 ↗ |
| Modality | Small molecule | — CHEMBL1290 ↗ |
| Target | ADRB1 | “Beta-1 adrenergic receptor antagonist” CHEMBL1290 ↗ |
| Target | ADRB2 | “Beta-2 adrenergic receptor antagonist” CHEMBL1290 ↗ |