Effects of Sodium Intake on (PK/PD) Relationship of a Single Dose of a Renin Angiotensin System-Blocker

Phase 1 Completed 64 enrolled Assistance Publique - Hôpitaux de Paris

RandomizedCrossoverOpen-labelTreatment

Summary

The impact of sodium intake on plasma drug concentrations has previously been reported in the literature for verapamil and quinidine but, to the investigators' knowledge, never with renin-angiotensin system blockers such as AT1R antagonists and angiotensin converting enzyme inhibitors.

Timeline

Start: 2006-03
Primary completion: 2007-03
Completion: 2007-03

Publications

Background Azizi M, Menard J, Bissery A, Guyenne TT, Bura-Riviere A, Vaidyanathan S, Camisasca RP. Pharmacologic demonstration of the synergistic effects of a combination of the renin inhibitor aliskiren and the AT1 receptor antagonist valsartan on the angiotensin II-renin feedback interruption. J Am Soc Nephrol. 2004 Dec;15(12):3126-33. doi: 10.1097/01.ASN.0000146686.35541.29.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Atenolol	Other / unclassified	50 mg	Oral
Subject	Candesartan	Unknown	8 mg	Oral
Subject	Ramipril	Small molecule	10 mg	Oral
Subject	Valsartan	Small molecule	160 mg	Oral

Indications

No indication recorded.