Drugs / LISINOPRIL ANHYDROUS
last change Jul 2026 re-read 2 minutes ago

LISINOPRIL ANHYDROUS

Small molecule targets ACE via inhibition

Developed for
hypertensive disorder · diabetic kidney disease · type 2 diabetes mellitus · cardiovascular disorder · essential hypertension · diabetes mellitus · heart disorder · coronary artery disorder
+40 more · pneumonia · type 1 diabetes mellitus · atherosclerosis · cardiomyopathy due to anthracyclines · cerebrovascular disorder · cognitive impairment with or without cerebellar ataxia · early onset hypertension · glomerulonephritis · heart failure · hepatocellular carcinoma · HIV infectious disease · intracranial arteriosclerosis · kidney disorder · metabolic dysfunction-associated steatohepatitis · non-small cell lung carcinoma · nonobstructive coronary artery disease · oligospermia · peripheral arterial disease · poisoning · polycythemia · preeclampsia · primary hyperparathyroidism · radiation-induced disorder · secondary hypertension · small cell lung carcinoma · stroke disorder · systolic heart failure · autosomal dominant polycystic kidney disease · Becker muscular dystrophy · cardiomyopathy · chronic kidney disease · diastolic heart failure · Duchenne muscular dystrophy · intermediate coronary syndrome · limb-girdle muscular dystrophy · malignant secondary hypertension · primary hyperoxaluria · proteinuria · resistant hypertension · systemic lupus erythematosus
Investigated by
GlaxoSmithKline · Novartis · UMC Utrecht · National Cancer Institute (NCI) · National Heart, Lung, and Blood Institute (NHLBI) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
+81 more · Brigham and Women's Hospital · Imperial College Healthcare NHS Trust · Imperial College London · Mayo Clinic · Novo Nordisk A/S · Par Pharmaceutical, Inc. · PharmaKinetics Laboratories Inc. · Royal College of Surgeons, Ireland · Steno Diabetes Center Copenhagen · The University of Texas Health Science Center, Houston · University of Rochester · Wake Forest University Health Sciences · Adil Bharucha · American Heart Association · Ascension Health · Assiut University · Australian and New Zealand Intensive Care Research Centre · Bayer · Berry Consultants · Cambridge University Hospitals NHS Foundation Trust · Cedars-Sinai Medical Center · Chinese University of Hong Kong · Dr. Reddy's Laboratories Limited · Duke University · Eli Lilly and Company · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) · European Commission · Forest Laboratories · Global Coalition for Adaptive Research · Hebrew SeniorLife · Hennepin County Medical Center, Minneapolis · Hennepin Healthcare Research Institute · Hoffmann-La Roche · Hospital do Coracao · Indiana University · Intarcia Therapeutics · Intensive Care National Audit & Research Centre · Istituto Di Ricerche Farmacologiche Mario Negri · Johns Hopkins University · Martin Huelsmann · Medical College of Wisconsin · Medical Research Council · Medical Research Institute of New Zealand · Merck Sharp & Dohme LLC · Monia Lorini · Nat Intensive Care Surveillance - MORU · National Center for Advancing Translational Sciences (NCATS) · National Center for Research Resources (NCRR) · National Hospital of Sri Lanka · National Institute on Aging (NIA) · National University Hospital, Singapore · Newcastle-upon-Tyne Hospitals NHS Trust · North East Ambulance Service NHS Foundation Trust · Northumbria Healthcare NHS Foundation Trust · Northwestern University · OpAns, LLC · Public Health Foundation of India · St. Marianna University School of Medicine · The Emmes Company, LLC · The George Institute · UNC Lineberger Comprehensive Cancer Center · US Department of Veterans Affairs · United States Department of Defense · Unity Health · University Ghent · University Of Nigeria Teaching Hospital · University at Buffalo · University of Aarhus · University of Florida · University of Leeds · University of Minnesota · University of Nebraska · University of Pittsburgh · University of Pittsburgh Medical Center · all 87 on the full record

Regulatory milestones approvals, filings & regulatory actions · 7 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Label expansions (4) US (FDA) ZESTRIL 1993-06-09 – 2003-07-01 fda.gov
Label expansions (2) US (FDA) PRINIVIL 1993-06-14 – 2003-05-29 fda.gov
Approved US (FDA) PRINIVIL 1987-12-29 fda.gov

Trials 66 · started per year

today
US approved 1987
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198719881989199019911992199319941995199619971998199920002001200220032004200520062007200820092010201120122013201420152016201720182019202020212022202320242025202620272028
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 01 trial
Phase 0 NCT05530655 Feb 2024 → Jan 2028 expected prostate cancer, radiation-induced disorder University of Rochester Recruiting No outcome recorded
Phase 115 trials
Phase 1 NCT06772779 Apr → Jun 2024 Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 1 NCT02641899 Dec 2015 → Mar 2016 Intarcia Therapeutics Completed No outcome recorded
Phase 1 NCT02232308 Jul → Sep 2014 gastroparesis Adil Bharucha Completed No outcome recorded
Phase 1 NCT02070510 Feb → Aug 2014 diabetes mellitus Novo Nordisk A/S Completed No outcome recorded
Phase 1 NCT01491919 Jun 2012 → Sep 2013 hypertensive disorder Uptal Patel Completed No outcome recorded
Phase 1 NCT01398267 Aug 2011 → Oct 2012 type 2 diabetes mellitus Hoffmann-La Roche Completed No outcome recorded
Phase 1 NCT01324388 Mar → Aug 2011 type 2 diabetes mellitus Eli Lilly and Company Completed No outcome recorded
Phase 1 NCT01066572 Oct 2010 → Dec 2011 stroke disorder Newcastle-upon-Tyne Hospitals NHS Trust Completed No outcome recorded
Phase 1 NCT00557128 Nov → Dec 2007 hypertensive disorder GlaxoSmithKline Completed No outcome recorded
Phase 1 NCT00537043 Oct 2007 → Jan 2008 essential hypertension GlaxoSmithKline Completed No outcome recorded
Phase 1/21 trial
Phase 1/2 NCT00553969 Nov 2007 → Sep 2010 hypertensive disorder University of Minnesota Completed No outcome recorded
Phase 211 trials
Phase 2 NCT07685938 Jul 2026 → Feb 2029 expected breast cancer, esophageal cancer, lung cancer, mediastinal cancer +2 UNC Lineberger Comprehensive Cancer Center Not yet recruiting No outcome recorded
Phase 2 NCT03422705 Dec 2022 University of Leeds Unknown No outcome recorded
Phase 2 NCT04977180 Mar 2022 → Mar 2028 expected acute myeloid leukemia University of Virginia Recruiting No outcome recorded
Phase 2 NCT04550481 May 2021 → Aug 2025 overdue hepatocellular carcinoma, metabolic dysfunction-associated steatohepatitis Northwestern University Active not recruiting No outcome recorded
Phase 2 NCT02682459 Feb 2016 → Sep 2019 glomerulonephritis Monia Lorini Unknown No outcome recorded
Phase 2 NCT01880528 May → Jun 2013 non-small cell lung carcinoma, small cell lung carcinoma Mayo Clinic Completed No outcome recorded
Phase 2 NCT01234922 Feb 2011 → Dec 2013 cancer of unknown primary site, hypertensive disorder Wake Forest University Health Sciences Terminated No outcome recorded
Phase 2 NCT01009918 Mar 2010 → Aug 2017 breast cancer, poisoning University of South Florida Completed No outcome recorded
Phase 2 NCT00567307 Jan → Dec 2009 cardiovascular disorder Wake Forest University Health Sciences Completed No outcome recorded
Phase 2 NCT00605072 Jan 2008 → Dec 2011 cognitive impairment with or without cerebellar ataxia, hypertensive disorder University of Southern California Completed No outcome recorded
Phase 312 trials
Phase 3 NCT02735707 Apr 2016 → Feb 2026 overdue pneumonia UMC Utrecht Recruiting No outcome recorded
Phase 3 NCT01313702 Oct 2012 → Apr 2014 cardiovascular disorder Hospital do Coracao Withdrawn No outcome recorded
Phase 3 NCT01326676 Feb 2011 → Jul 2012 cardiovascular disorder Imperial College London Withdrawn No outcome recorded
Phase 3 NCT01057537 Jun 2010 → Jul 2012 cardiovascular disorder Imperial College London Completed No outcome recorded
Phase 3 NCT00555217 Jul 2008 → Sep 2014 kidney disorder, type 2 diabetes mellitus US Department of Veterans Affairs Terminated No outcome recorded
Phase 3 NCT00624065 Mar → Aug 2008 essential hypertension GlaxoSmithKline Completed No outcome recorded
Phase 3 NCT00347360 Jul 2006 → Apr 2008 hypertensive disorder GlaxoSmithKline Completed No outcome recorded
Phase 3 NCT00582114 Aug 2005 → Sep 2013 essential hypertension, heart disorder Indiana University Terminated No outcome recorded
Phase 3 NCT00108082 Jan 2005 → Aug 2008 heart disorder GlaxoSmithKline Completed No outcome recorded
Phase 3 NCT00171067 Jul 2004 → May 2007 hypertensive disorder Novartis Completed No outcome recorded
Phase 417 trials
Phase 4 NCT07594535 Jul 2026 → Jul 2028 expected polycythemia Mayo Clinic Not yet recruiting No outcome recorded
Phase 4 NCT05049616 Oct 2021 → Jun 2022 preeclampsia The University of Texas Health Science Center, Houston Completed No outcome recorded
Phase 4 NCT03461003 Apr 2018 → Nov 2020 early onset hypertension The University of Texas Health Science Center, Houston Completed No outcome recorded
Phase 4 NCT03392740 Mar → Dec 2018 cardiomyopathy due to anthracyclines, systolic heart failure Ascension Health Withdrawn No outcome recorded
Phase 4 NCT03417388 Feb 2018 → Sep 2026 expected nonobstructive coronary artery disease Cedars-Sinai Medical Center Active not recruiting No outcome recorded
Phase 4 NCT02847338 Nov 2016 → Oct 2023 hypertensive disorder Cambridge University Hospitals NHS Foundation Trust Completed No outcome recorded
Phase 4 NCT02817360 Feb 2016 → Dec 2025 overdue heart disorder, type 2 diabetes mellitus Martin Huelsmann Recruiting No outcome recorded
Phase 4 NCT01669434 Jun 2015 → Nov 2016 University of Nebraska Completed No outcome recorded
Phase 4 NCT02184858 Jun 2014 → May 2017 essential hypertension, secondary hypertension University Ghent Completed No outcome recorded
Phase 4 NCT01218100 Oct 2010 → May 2011 hypertensive disorder Forest Laboratories Completed No outcome recorded
Phase not applicable9 trials
NCT06187493 Jan 2024 → Jan 2025 diabetic kidney disease Assiut University Unknown No outcome recorded
NCT01867047 Jun 2013 → Jun 2016 hypotensive disorder Duke University Terminated No outcome recorded
NCT01691781 Oct 2012 → Aug 2016 primary hyperparathyroidism Brigham and Women's Hospital Completed No outcome recorded
NCT01506505 Jul 2012 → Jul 2013 cerebrovascular disorder, peripheral arterial disease UMC Utrecht Completed No outcome recorded
NCT00982189 Sep 2009 → Dec 2010 HIV infectious disease, cardiovascular disorder Hennepin Healthcare Research Institute Completed No outcome recorded
NCT01009944 Jan 2007 → Mar 2019 hypertensive disorder Brigham and Women's Hospital Withdrawn No outcome recorded
NCT00337298 Jul 2006 → Feb 2009 diabetic retinopathy, type 1 diabetes mellitus University of Aarhus Completed No outcome recorded
NCT00118976 Mar 2005 → Sep 2006 diabetic kidney disease, type 1 diabetes mellitus Steno Diabetes Center Copenhagen Completed No outcome recorded
NCT00151138 Sep 2002 → May 2007 hypertensive disorder University of Pittsburgh Completed No outcome recorded
Also used as a comparator or background therapy in 50 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 11 trial
Phase 1 NCT02623036 Comparator Nov 2015 → Apr 2018 resistant hypertension Memorial Health University Medical Center Unknown No outcome recorded
Phase 28 trials
Phase 2 NCT04486118 Comparator Oct 2021 → Jun 2025 overdue systemic lupus erythematosus Northwell Health Active not recruiting No outcome recorded
Phase 2 NCT03201939 Comparator Apr → Nov 2021 HIV infectious disease, proteinuria Vanderbilt University Medical Center Terminated No outcome recorded
Phase 2 NCT04190433 Background Sep 2020 → Apr 2023 breast carcinoma, lymphoma, sarcoma Mayo Clinic Withdrawn No outcome recorded
Phase 2 NCT02603809 Comparator Dec 2015 → Feb 2017 essential hypertension Idorsia Pharmaceuticals Ltd. Completed No outcome recorded
Phase 2 NCT01984164 Comparator Aug 2014 → Dec 2018 cognitive impairment with or without cerebellar ataxia, hypertensive disorder Emory University Completed No outcome recorded
Phase 2/31 trial
Phase 2/3 NCT01126697 Comparator Feb 2010 → Dec 2017 Becker muscular dystrophy, Duchenne muscular dystrophy, limb-girdle muscular dystrophy Cooperative International Neuromuscular Research Group Completed No outcome recorded
Phase 37 trials
Phase 3 NCT05056727 Background Sep 2021 → Feb 2024 chronic kidney disease AstraZeneca Terminated No outcome recorded
Phase 3 NCT01437371 Background Aug 2011 → Jun 2014 heart failure University Hospital, Clermont-Ferrand Completed No outcome recorded
Phase 3 NCT00280215 Comparator Dec 2007 → Dec 2011 primary hyperoxaluria Mayo Clinic Withdrawn No outcome recorded
Phase 3 NCT00459056 Background Apr 2007 → May 2010 abdominal obesity-metabolic syndrome, hypertensive disorder St. Paul Heart Clinic Completed No outcome recorded
Phase 3 NCT01885559 Comparator Jan 2006 → Jun 2014 autosomal dominant polycystic kidney disease National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Completed No outcome recorded
Phase 419 trials
Phase 4 NCT07547878 Comparator Apr 2026 → Mar 2029 expected chronic kidney disease, type 2 diabetes mellitus Baylor Research Institute Not yet recruiting No outcome recorded
Phase 4 NCT07513883 Background Mar 2026 → Sep 2028 expected heart failure Ziekenhuis Oost-Limburg Recruiting No outcome recorded
Phase 4 NCT04662723 Background May 2023 → Jun 2026 overdue IgA glomerulonephritis Schena Foundation Recruiting No outcome recorded
Phase 4 NCT05644769 Comparator Nov 2022 → Mar 2023 hypertensive disorder Trinity Hypertension & Metabolic Research Institute Unknown No outcome recorded
Phase 4 NCT04330300 Comparator Apr 2020 → Jul 2021 COVID-19, essential hypertension National University of Ireland, Galway, Ireland Suspended No outcome recorded
Phase not applicable14 trials
NCT07568574 Background Mar 2026 → May 2028 expected Enhanced Emirates Limited Enrolling by invitation No outcome recorded
NCT05016440 Comparator Sep 2015 preeclampsia, proteinuria Eastern Virginia Medical School Withdrawn No outcome recorded
NCT02412761 Comparator Jun 2013 → Jul 2016 essential hypertension The University of Texas Health Science Center, Houston Completed No outcome recorded
NCT01996085 Comparator Jan 2013 → Jun 2016 hypertensive disorder Military Institute od Medicine National Research Institute Completed No outcome recorded
NCT01658657 Comparator Oct 2012 → Jul 2014 hypertensive disorder, proteolytic capacity of plasma University of North Carolina, Chapel Hill Completed No outcome recorded

Press releases naming this drug 1 release

DateIssuerRelease
2002-07-01 Teva Branded Pharmaceutical Products R&D, Inc. Teva Announces Approval of Lisinopril Tablets and Lisinopril HCTZ Tablets tevapharm.com

Evidence & citations 22 cited values

Every value below carries the sentence it was read from. 118 sources stand behind the page.

FieldValueCited text
Known as LISINOPRIL ANHYDROUS ChEMBL registry synonym — accepted as the source's own label CHEMBL1237
Known as ACE Inhibitors ClinicalTrials.gov intervention name — accepted as the source's own label NCT00241904
Known as Carace ChEMBL registry synonym — accepted as the source's own label CHEMBL1237
Known as Diroton “Antihypertensive: "Diroton" (Lisinopril, Gedeon Richter Ltd) - 10mg twice per day” NCT01700075
Known as lisinopril “The pharmacological treatment intended to enhance reverse remodeling includes 4 drugs initiated immediately after weaning of inotropic support once achieving adequate end-organ...” NCT01774656
113

“Examples of possible ACE-I drugs include: benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec, Epaned), fosinopril (Monopril), lisinopril (Prinivil, Zestril),...” NCT01867047

“This study is to compare carvedilol controlled release to carvedilol controlled release plus lisinopril (fixed-dose combination) after repeat dosing in patients with high blood...” NCT00537043

“Version 1 contains aspirin 75mg, simvastatin 40mg, Lisinopril 10mg and Atenolol 50mg; Version 2 contains aspirin 75mg, simvastatin 40mg, Lisinopril 10mg and Hydrochlorothiazide 12.5mg.” NCT01057537

“Version 1 contains aspirin 75mg, simvastatin 40mg, Lisinopril 10mg and Atenolol 50mg; Version 2 contains aspirin 75mg, simvastatin 40mg, Lisinopril 10mg and Hydrochlorothiazide 12.5mg.” NCT01326676

“RAAS (Lisinopril, Enalapril, Perindopril, Losartan, and Valsartan taken each day at maximum tolerated dose that will different for each subject)” NCT03502031

“The trial compared a Polypill (75 mg aspirin, 20 mg simvastatin, 10 mg lisinopril and 12.5 mg hydrochlorothiazide) to Standard Practice.” PMID 21205325 Jan 2011

“the cardiovascular polypill (aspirin 75 mg, simvastatin 40 mg, lisinopril 10 mg, and hydrochlorothiazide 12.5 mg) in the evening” PMID 23382539 Feb 2013

“Benazepril, captopril, enalapril, fosinopril, lisinopril, perindopril, quinapril, ramipril, trandolapril” NCT04330300

“either a combined pill of ACE inhibitors and diuretics (Hydrochlorothiazide/Lisinopril)” NCT05049616

“Preventive beta blocker (metoprolol or carvedilol) and an ACE inhibitor (lisinopril)” NCT04977180

“polipill version 1: aspirin 75mg, simvastatin 40mg, lisinopril 10mg, atenolol 50mg” NCT01313702

“Antihypertensive: "Diroton" (Lisinopril, Gedeon Richter Ltd) - 10mg twice per day” NCT01700075

“ACE inhibitor: enalapril, lisinopril, ramipril, captopril or trandolapril” NCT07513883

“enalapril, fosinopril, lisinopril, moexipril, perindopril” NCT00684489

lisinopril: 20 mg/d→10 mg/d→5 mg/d→2,5 mg/d→stop” NCT02200822

lisinopril 10 mg daily in adult patients” NCT00280215

Lisinopril 40mg/d” NCT02817360

LisinoprilNCT00741585

lisinoprilNCT04662723

LisinoprilNCT02735707

lisinoprilNCT01669434

NCT01398267

NCT07547878

NCT00004266

NCT01996085

NCT02184858

NCT04550481

NCT00673790

NCT00430040

NCT05016440

NCT04190433

NCT02847338

NCT02412761

NCT00982189

NCT00241124

NCT01982695

NCT01691781

NCT00773084

NCT03461003

NCT00814255

NCT00295542

NCT01880528

NCT01218100

NCT00605072

NCT00283686

NCT00557128

NCT01324388

NCT00508365

NCT00000542

NCT01258764

NCT02441842

NCT03392740

NCT00549510

NCT01409837

NCT00553969

NCT00118976

NCT03422705

NCT00661895

NCT00624065

NCT00311870

NCT01901549

NCT02641899

NCT04486118

NCT01076140

NCT00582114

NCT01375244

NCT00743197

NCT01984164

NCT01380431

NCT01437371

NCT01009918

NCT07685938

NCT01837069

NCT01101269

NCT03417388

NCT00151138

NCT00337298

NCT06772779

NCT02336607

NCT00171600

NCT02358642

NCT03201939

NCT02232308

NCT00347360

NCT01491919

NCT00555217

NCT07594535

NCT01009944

NCT01885559

NCT01535235

NCT00108082

NCT02682459

NCT00123903

NCT05644769

NCT00874432

NCT00459056

NCT00292162

NCT03195023

NCT01126697

NCT02603809

NCT05056727

NCT05530655

NCT01234922

NCT00171067

NCT01518166

NCT01066572

NCT02070510

NCT01658657

NCT06187493

NCT07568574

NCT00171574

NCT02623036

NCT00391846

Known as Lisinopril component of prinzide ChEMBL registry synonym — accepted as the source's own label CHEMBL1237
Known as Lisinopril component of zestoretic ChEMBL registry synonym — accepted as the source's own label CHEMBL1237
Known as Lisinopril dihydrate ChEMBL registry synonym — accepted as the source's own label CHEMBL1237
Known as LISINOPRIL HYDRATE ChEMBL registry synonym — accepted as the source's own label CHEMBL1237
Known as Lisopress ChEMBL registry synonym — accepted as the source's own label CHEMBL1237
Known as MK-521 ChEMBL registry synonym — accepted as the source's own label CHEMBL1237
Known as NSC-751176 ChEMBL registry synonym — accepted as the source's own label CHEMBL1237
Known as NSC-758151 ChEMBL registry synonym — accepted as the source's own label CHEMBL1237
Known as Prinivil “Examples of possible ACE-I drugs include: benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec, Epaned), fosinopril (Monopril), lisinopril (Prinivil, Zestril),...” NCT01867047
Known as Prinivil, Zestril (Lisinopril) Prinivil, Zestril (Lisinopril)NCT01009944
Known as Qbrelis ChEMBL registry synonym — accepted as the source's own label CHEMBL1237
Known as Ranolip ChEMBL registry synonym — accepted as the source's own label CHEMBL1237
Known as Zestril “Examples of possible ACE-I drugs include: benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec, Epaned), fosinopril (Monopril), lisinopril (Prinivil, Zestril),...” NCT01867047
3

“10mg, 20mg, or 40mg QD Doses of Lisinopril (Zestril) or a Combination” NCT00347360

“Lisinopril (Zestril) 10mg, once daily.” NCT02336607

NCT02774460

Action Inhibit “lisinopril, an angiotensin-converting enzyme inhibitor” PMID 24842697 Jul 2014
Modality Small molecule CHEMBL1237
Route Oral Oral medication.” NCT00459056
Target ACE “the ACE inhibitor, lisinopril: 20, 40 and 60 mg daily” NCT00118976