Drugs / LISINOPRIL ANHYDROUS
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LISINOPRIL ANHYDROUS

Small molecule targets ACE via inhibition

Developed for
hypertensive disorder · diabetic kidney disease · type 2 diabetes mellitus · cardiovascular disorder · essential hypertension · heart disorder · pneumonia · type 1 diabetes mellitus
+36 more · cardiomyopathy due to anthracyclines · cerebrovascular disorder · cognitive impairment with or without cerebellar ataxia · early onset hypertension · glomerulonephritis · heart failure · hepatocellular carcinoma · HIV infectious disease · kidney disorder · metabolic dysfunction-associated steatohepatitis · non-small cell lung carcinoma · nonobstructive coronary artery disease · oligospermia · peripheral arterial disease · poisoning · polycythemia · preeclampsia · primary hyperparathyroidism · radiation-induced disorder · secondary hypertension · small cell lung carcinoma · stroke disorder · systolic heart failure · autosomal dominant polycystic kidney disease · Becker muscular dystrophy · cardiomyopathy · chronic kidney disease · diastolic heart failure · Duchenne muscular dystrophy · intermediate coronary syndrome · limb-girdle muscular dystrophy · malignant secondary hypertension · primary hyperoxaluria · proteinuria · resistant hypertension · systemic lupus erythematosus
Investigated by
GlaxoSmithKline · Novartis · UMC Utrecht · National Cancer Institute (NCI) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · Brigham and Women's Hospital
+80 more · Imperial College Healthcare NHS Trust · Imperial College London · Mayo Clinic · National Heart, Lung, and Blood Institute (NHLBI) · Novo Nordisk A/S · Par Pharmaceutical, Inc. · PharmaKinetics Laboratories Inc. · Royal College of Surgeons, Ireland · Steno Diabetes Center Copenhagen · The University of Texas Health Science Center, Houston · University of Rochester · Wake Forest University Health Sciences · Adil Bharucha · American Heart Association · Ascension Health · Assiut University · Australian and New Zealand Intensive Care Research Centre · Bayer · Berry Consultants · Cambridge University Hospitals NHS Foundation Trust · Cedars-Sinai Medical Center · Chinese University of Hong Kong · Dr. Reddy's Laboratories Limited · Duke University · Eli Lilly and Company · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) · European Commission · Forest Laboratories · Global Coalition for Adaptive Research · Hebrew SeniorLife · Hennepin County Medical Center, Minneapolis · Hennepin Healthcare Research Institute · Hoffmann-La Roche · Hospital do Coracao · Indiana University · Intarcia Therapeutics · Intensive Care National Audit & Research Centre · Istituto Di Ricerche Farmacologiche Mario Negri · Martin Huelsmann · Medical College of Wisconsin · Medical Research Council · Medical Research Institute of New Zealand · Merck Sharp & Dohme LLC · Monia Lorini · Nat Intensive Care Surveillance - MORU · National Center for Advancing Translational Sciences (NCATS) · National Center for Research Resources (NCRR) · National Hospital of Sri Lanka · National Institute on Aging (NIA) · National University Hospital, Singapore · Newcastle-upon-Tyne Hospitals NHS Trust · North East Ambulance Service NHS Foundation Trust · Northumbria Healthcare NHS Foundation Trust · Northwestern University · OpAns, LLC · Public Health Foundation of India · St. Marianna University School of Medicine · The Emmes Company, LLC · The George Institute · UNC Lineberger Comprehensive Cancer Center · US Department of Veterans Affairs · United States Department of Defense · Unity Health · University Ghent · University Of Nigeria Teaching Hospital · University at Buffalo · University of Aarhus · University of Florida · University of Leeds · University of Minnesota · University of Nebraska · University of Pittsburgh · University of Pittsburgh Medical Center · University of South Florida · all 86 on the full record

Regulatory milestones approvals, filings & regulatory actions · 5 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Label expansion US (FDA) PRINIVIL — 2003-05-29 fda.gov ↗
Label expansions (3) US (FDA) ZESTRIL — 1993-06-09 – 2000-02-07 fda.gov ↗
Approved US (FDA) PRINIVIL — 1987-12-29 fda.gov ↗

Trials 65 · started per year

today
US approved 1987
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PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 01 trial
Phase 0 NCT05530655 Feb 2024 → Jan 2028 expected prostate cancer, radiation-induced disorder University of Rochester Recruiting No outcome recorded
Phase 115 trials · 1 missed
Phase 1 NCT06772779 Apr → Jun 2024 — Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 1 NCT02641899 Dec 2015 → Mar 2016 — Intarcia Therapeutics Completed No outcome recorded
Phase 1 NCT02232308 Jul → Sep 2014 gastroparesis Adil Bharucha Completed No outcome recorded
Phase 1 NCT02070510 Feb → Aug 2014 diabetes mellitus Novo Nordisk A/S Completed No outcome recorded
Phase 1 NCT01491919 Jun 2012 → Sep 2013 hypertensive disorder Uptal Patel Completed No outcome recorded
Phase 1 NCT01398267 Aug 2011 → Oct 2012 type 2 diabetes mellitus Hoffmann-La Roche Completed No outcome recorded
Phase 1 NCT01324388 Mar → Aug 2011 type 2 diabetes mellitus Eli Lilly and Company Completed No outcome recorded
Phase 1 NCT01066572 Oct 2010 → Dec 2011 stroke disorder Newcastle-upon-Tyne Hospitals NHS Trust Completed No outcome recorded
Phase 1 NCT00557128 Nov → Dec 2007 hypertensive disorder GlaxoSmithKline Completed No outcome recorded
Phase 1 NCT00549510 Oct → Dec 2007 hypertensive disorder GlaxoSmithKline Completed No outcome recorded
Phase 1/21 trial
Phase 1/2 NCT00553969 Nov 2007 → Sep 2010 hypertensive disorder University of Minnesota Completed No outcome recorded
Phase 211 trials · 1 missed
Phase 2 NCT07685938 Aug 2026 → Feb 2029 expected breast cancer, esophageal cancer, lung cancer, mediastinal cancer +2 UNC Lineberger Comprehensive Cancer Center Recruiting No outcome recorded
Phase 2 NCT03422705 Dec 2022 — University of Leeds Unknown No outcome recorded
Phase 2 NCT04977180 Mar 2022 → Mar 2028 expected acute myeloid leukemia University of Virginia Recruiting No outcome recorded
Phase 2 NCT04550481 May 2021 → Aug 2025 overdue hepatocellular carcinoma, metabolic dysfunction-associated steatohepatitis Northwestern University Active not recruiting No outcome recorded
Phase 2 NCT02682459 Feb 2016 → Sep 2019 glomerulonephritis Monia Lorini Unknown No outcome recorded
Phase 2 NCT01880528 May → Jun 2013 non-small cell lung carcinoma, small cell lung carcinoma Mayo Clinic Completed No outcome recorded
Phase 2 NCT01234922 Feb 2011 → Dec 2013 cancer of unknown primary site, hypertensive disorder Wake Forest University Health Sciences Terminated No outcome recorded Stop: Enrollment
Phase 2 NCT01009918 Mar 2010 → Aug 2017 breast cancer, poisoning University of South Florida Completed No outcome recorded
Phase 2 NCT00567307 Jan → Dec 2009 cardiovascular disorder Wake Forest University Health Sciences Completed Missed primary
Phase 2 NCT00605072 Jan 2008 → Dec 2011 cognitive impairment with or without cerebellar ataxia, hypertensive disorder University of Southern California Completed Mixed
Phase 312 trials · 1 met primary · 6 missed
Phase 3 NCT02735707 Apr 2016 → Feb 2026 overdue pneumonia UMC Utrecht Recruiting Mixed
Phase 3 NCT01313702 Oct 2012 → Apr 2014 cardiovascular disorder Hospital do Coracao Withdrawn No outcome recorded
Phase 3 NCT01326676 Feb 2011 → Jul 2012 cardiovascular disorder Imperial College London Withdrawn No outcome recorded Stop: Business
Phase 3 NCT01057537 Jun 2010 → Jul 2012 cardiovascular disorder Imperial College London Completed Met primary
Phase 3 NCT00555217 Jul 2008 → Sep 2014 kidney disorder, type 2 diabetes mellitus US Department of Veterans Affairs Terminated Missed primary
Phase 3 NCT00624065 Mar → Aug 2008 essential hypertension GlaxoSmithKline Completed Missed primary
Phase 3 NCT00347360 Jul 2006 → Apr 2008 hypertensive disorder GlaxoSmithKline Completed Missed primary
Phase 3 NCT00582114 Aug 2005 → Sep 2013 essential hypertension, heart disorder Indiana University Terminated Missed primary
Phase 3 NCT00108082 Jan 2005 → Aug 2008 heart disorder GlaxoSmithKline Completed Missed primary
Phase 3 NCT00171067 Jul 2004 → May 2007 hypertensive disorder Novartis Completed No outcome recorded
Phase 416 trials · 1 met primary · 1 missed
Phase 4 NCT07594535 Jul 2026 → Jul 2028 expected polycythemia Mayo Clinic Not yet recruiting No outcome recorded
Phase 4 NCT05049616 Oct 2021 → Jun 2022 preeclampsia The University of Texas Health Science Center, Houston Completed No outcome recorded
Phase 4 NCT03461003 Apr 2018 → Nov 2020 early onset hypertension The University of Texas Health Science Center, Houston Completed No outcome recorded
Phase 4 NCT03392740 Mar → Dec 2018 cardiomyopathy due to anthracyclines, systolic heart failure Ascension Health Withdrawn No outcome recorded
Phase 4 NCT03417388 Feb 2018 → Sep 2026 overdue nonobstructive coronary artery disease Cedars-Sinai Medical Center Active not recruiting Missed primary
Phase 4 NCT02847338 Nov 2016 → Oct 2023 hypertensive disorder Cambridge University Hospitals NHS Foundation Trust Completed No outcome recorded
Phase 4 NCT02817360 Feb 2016 → Dec 2025 overdue heart disorder, type 2 diabetes mellitus Martin Huelsmann Recruiting No outcome recorded
Phase 4 NCT01669434 Jun 2015 → Nov 2016 — University of Nebraska Completed Met primary
Phase 4 NCT02184858 Jun 2014 → May 2017 essential hypertension, secondary hypertension University Ghent Completed No outcome recorded
Phase 4 NCT01218100 Oct 2010 → May 2011 hypertensive disorder Forest Laboratories Completed No outcome recorded
Phase not applicable9 trials · 1 met primary · 1 missed
— NCT06187493 Jan 2024 → Jan 2025 diabetic kidney disease Assiut University Unknown No outcome recorded
— NCT01867047 Jun 2013 → Jun 2016 hypotensive disorder Duke University Terminated Missed primary
— NCT01691781 Oct 2012 → Aug 2016 primary hyperparathyroidism Brigham and Women's Hospital Completed Met primary
— NCT01506505 Jul 2012 → Jul 2013 cerebrovascular disorder, peripheral arterial disease UMC Utrecht Completed Mixed
— NCT00982189 Sep 2009 → Dec 2010 HIV infectious disease, cardiovascular disorder Hennepin Healthcare Research Institute Completed No outcome recorded
— NCT01009944 Jan 2007 → Mar 2019 hypertensive disorder Brigham and Women's Hospital Withdrawn No outcome recorded Stop: Business
— NCT00337298 Jul 2006 → Feb 2009 diabetic retinopathy, type 1 diabetes mellitus University of Aarhus Completed No outcome recorded
— NCT00118976 Mar 2005 → Sep 2006 diabetic kidney disease, type 1 diabetes mellitus Steno Diabetes Center Copenhagen Completed No outcome recorded
— NCT00151138 Sep 2002 → May 2007 hypertensive disorder University of Pittsburgh Completed No outcome recorded
Comparator or background therapy50 trials
Phase 1 NCT02623036 Comparator Nov 2015 → Apr 2018 resistant hypertension Memorial Health University Medical Center Unknown No outcome recorded
Phase 2 NCT04486118 Comparator Oct 2021 → Jun 2025 overdue systemic lupus erythematosus Northwell Health Active not recruiting No outcome recorded
Phase 2 NCT03201939 Comparator Apr → Nov 2021 HIV infectious disease, proteinuria Vanderbilt University Medical Center Terminated No outcome recorded
Phase 2 NCT04190433 Background Sep 2020 → Apr 2023 breast carcinoma, lymphoma, sarcoma Mayo Clinic Withdrawn No outcome recorded Stop: Enrollment
Phase 2 NCT02603809 Comparator Dec 2015 → Feb 2017 essential hypertension Idorsia Pharmaceuticals Ltd. Completed Met primary

News releases announcing trial results or a regulatory action · 1

DateIssuerRelease
2002-07-01 Teva Branded Pharmaceutical Products R&D, Inc. Regulatory Teva Announces Approval of Lisinopril Tablets and Lisinopril HCTZ Tablets tevapharm.com ↗
has issued final approval for the company's ANDA for Lisinopril Tablets USP, 2.5 mg, 5 mg, 10 mg, 20 mg, 30 mg and 40 mg as well as its ANDA for Lisinopril and Hydrochlorothiazide Tablets

All press releases naming this drug 1 release

DateIssuerRelease

Evidence & citations 21 cited values

Every value below carries the sentence it was read from. 117 sources stand behind the page.

FieldValueCited text
Known as LISINOPRIL ANHYDROUS ChEMBL registry synonym — accepted as the source's own label CHEMBL1237 ↗
Known as Carace ChEMBL registry synonym — accepted as the source's own label CHEMBL1237 ↗
Known as Diroton “Antihypertensive: "Diroton" (Lisinopril, Gedeon Richter Ltd) - 10mg twice per day” NCT01700075 ↗
Known as Lisinopril “The pharmacological treatment intended to enhance reverse remodeling includes 4 drugs initiated immediately after weaning of inotropic support once achieving adequate end-organ...” NCT01774656 ↗
113

“Examples of possible ACE-I drugs include: benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec, Epaned), fosinopril (Monopril), lisinopril (Prinivil, Zestril),...” NCT01867047 ↗

“This study is to compare carvedilol controlled release to carvedilol controlled release plus lisinopril (fixed-dose combination) after repeat dosing in patients with high blood...” NCT00537043 ↗

“Version 1 contains aspirin 75mg, simvastatin 40mg, Lisinopril 10mg and Atenolol 50mg; Version 2 contains aspirin 75mg, simvastatin 40mg, Lisinopril 10mg and Hydrochlorothiazide 12.5mg.” NCT01326676 ↗

“Version 1 contains aspirin 75mg, simvastatin 40mg, Lisinopril 10mg and Atenolol 50mg; Version 2 contains aspirin 75mg, simvastatin 40mg, Lisinopril 10mg and Hydrochlorothiazide 12.5mg.” NCT01057537 ↗

“RAAS (Lisinopril, Enalapril, Perindopril, Losartan, and Valsartan taken each day at maximum tolerated dose that will different for each subject)” NCT03502031 ↗

“The trial compared a Polypill (75 mg aspirin, 20 mg simvastatin, 10 mg lisinopril and 12.5 mg hydrochlorothiazide) to Standard Practice.” PMID 21205325 ↗ Jan 2011

“the cardiovascular polypill (aspirin 75 mg, simvastatin 40 mg, lisinopril 10 mg, and hydrochlorothiazide 12.5 mg) in the evening” PMID 23382539 ↗ Feb 2013

“Benazepril, captopril, enalapril, fosinopril, lisinopril, perindopril, quinapril, ramipril, trandolapril” NCT04330300 ↗

“either a combined pill of ACE inhibitors and diuretics (Hydrochlorothiazide/Lisinopril)” NCT05049616 ↗

“Preventive beta blocker (metoprolol or carvedilol) and an ACE inhibitor (lisinopril)” NCT04977180 ↗

Show 103 more sources

Known as Lisinopril component of prinzide ChEMBL registry synonym — accepted as the source's own label CHEMBL1237 ↗
Known as Lisinopril component of zestoretic ChEMBL registry synonym — accepted as the source's own label CHEMBL1237 ↗
Known as Lisinopril dihydrate ChEMBL registry synonym — accepted as the source's own label CHEMBL1237 ↗
Known as LISINOPRIL HYDRATE ChEMBL registry synonym — accepted as the source's own label CHEMBL1237 ↗
Known as Lisopress ChEMBL registry synonym — accepted as the source's own label CHEMBL1237 ↗
Known as MK-521 ChEMBL registry synonym — accepted as the source's own label CHEMBL1237 ↗
Known as NSC-751176 ChEMBL registry synonym — accepted as the source's own label CHEMBL1237 ↗
Known as NSC-758151 ChEMBL registry synonym — accepted as the source's own label CHEMBL1237 ↗
Known as Prinivil “Examples of possible ACE-I drugs include: benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec, Epaned), fosinopril (Monopril), lisinopril (Prinivil, Zestril),...” NCT01867047 ↗
Known as Prinivil, Zestril (Lisinopril) “Prinivil, Zestril (Lisinopril)” NCT01009944 ↗
Known as Qbrelis ChEMBL registry synonym — accepted as the source's own label CHEMBL1237 ↗
Known as Ranolip ChEMBL registry synonym — accepted as the source's own label CHEMBL1237 ↗
Known as Zestril “Examples of possible ACE-I drugs include: benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec, Epaned), fosinopril (Monopril), lisinopril (Prinivil, Zestril),...” NCT01867047 ↗
3

“10mg, 20mg, or 40mg QD Doses of Lisinopril (Zestril) or a Combination” NCT00347360 ↗

“Lisinopril (Zestril) 10mg, once daily.” NCT02336607 ↗

NCT02774460 ↗

Action Inhibit “lisinopril, an angiotensin-converting enzyme inhibitor” PMID 24842697 ↗ Jul 2014
Modality Small molecule — CHEMBL1237 ↗
Route Oral “Oral medication.” NCT00459056 ↗
Target ACE “the ACE inhibitor, lisinopril: 20, 40 and 60 mg daily” NCT00118976 ↗