drugset / Trial / NCT02774460
The Precision Hypertension Care Study
RandomizedCrossoverQuadruple-blindTreatment
Summary
The PHYSIC study aims to investigate the potential for precision medicine in the treatment of high blood pressure. It is a double-blind, randomized, repeated cross-over trial with six treatment periods: four classes of blood pressure-lowering drugs where treatment with two classes are repeated for each patient. The classes of blood pressure-lowering drugs to be tested are a diuretic, a calcium channel blocker, an ACE-inhibitor and an angiotensin receptor blocker.
Timeline
- Start
- 2017-02-20
- Primary completion
- 2021-06-11
- Completion
- 2021-06-11
Publications
- Background Sundstrom J, Lind L, Nowrouzi S, Lytsy P, Marttala K, Ekman I, Ohagen P, Ostlund O. The Precision HYpertenSIon Care (PHYSIC) study: a double-blind, randomized, repeated cross-over study. Ups J Med Sci. 2019 Jan;124(1):51-58. doi: 10.1080/03009734.2018.1498958. Epub 2018 Sep 28.
- Sundstrom J, Lind L, Nowrouzi S, Hagstrom E, Held C, Lytsy P, Neal B, Marttala K, Ostlund O. Heterogeneity in Blood Pressure Response to 4 Antihypertensive Drugs: A Randomized Clinical Trial. JAMA. 2023 Apr 11;329(14):1160-1169. doi: 10.1001/jama.2023.3322.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Amlodipine | Other / unclassified | 10 mg | — |
| Comparator | Candesartan cilexetil | Unknown | 16 mg | — |
| Comparator | Hydrochlorothiazide | Unknown | 25 mg | — |
| Comparator | LISINOPRIL ANHYDROUS | Small molecule | 20 mg | — |