drugset / Trial / NCT00553969

Efficacy of Coreg CR and Lisinopril on Markers for Cardiovascular Functional and Structural Disease

NCT00553969

Phase 1/2 Completed 101 enrolled University of Minnesota GlaxoSmithKline · collab
RandomizedFactorialQuadruple-blindTreatment

Summary

This study will examine the individual and combined effects of Coreg CR and lisinopril, on cardiovascular health as measured by Rasmussen Disease Score (RDS) in a blinded, placebo controlled comparison over a 9-month study period. Patients to be randomized will have pre-hypertensive blood pressures that do not require anti-hypertensive therapy and at least one additional cardiovascular risk factor.

Timeline

Start
2007-11
Primary completion
2010-09
Completion
2010-12

Drugs

EvaluationDrugModalityDoseRoute
Subject Carvedilol Other / unclassified 40 mg
Subject LISINOPRIL ANHYDROUS Small molecule 20 mg

Indications