drugset / Trial / NCT01867047
ACE-Inhibitor Effects on Total Hip and Knee Arthroplasty Patients
RandomizedParallel-groupOpen-labelSupportive care
Summary
The purpose of this study is to determine the effects of Angiotension Converting Enzyme Inhibitors (ACE-I) during surgery and in the immediate postoperative period for patients undergoing elective total hip or knee arthroplasty.
Timeline
- Start
- 2013-06
- Primary completion
- 2016-06-24
- Completion
- 2016-06-24
Outcome
Missed primary endpoint
Stopped: “Following an interim analysis the study team felt that there was enough data that showed no significant difference.”
registry analysis (superiority test); Continuation Group vs Cessation Group; p = 0.140; t-test, 2 sided NCT01867047 ↗
registry analysis (superiority test); Continuation Group vs Cessation Group; p = 0.102; t-test, 2 sided NCT01867047 ↗
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Benazepril | Unknown | — | — |
| Subject | Captopril | Small molecule | — | — |
| Subject | Enalapril | Other / unclassified | — | — |
| Subject | Fosinopril | Small molecule | — | — |
| Subject | LISINOPRIL ANHYDROUS | Small molecule | — | — |
| Subject | Moexipril | Small molecule | — | — |
| Subject | Perindopril | Small molecule | — | — |
| Subject | Quinapril | Small molecule | — | — |
| Subject | Ramipril | Small molecule | — | — |
| Subject | trandolapril | Small molecule | — | — |