A Trial Investigating the Influence of Oral Semaglutide on the Pharmacokinetics of Lisinopril and Warfarin in Healthy Subjects

NCT02070510 ↗

Phase 1 Completed 52 enrolled Novo Nordisk A/S

Non-randomizedCrossoverOpen-labelTreatment

Summary

This trial is conducted in Europe. The aim of the trial is to investigate the influence of oral semaglutide (NNC0113-0217) on the pharmacokinetics of lisinopril and warfarin in healthy subjects.

Timeline

Start: 2014-02-27
Primary completion: 2014-08-20
Completion: 2014-08-20

Publications

Background Baekdal TA, Borregaard J, Hansen CW, Thomsen M, Anderson TW. Effect of Oral Semaglutide on the Pharmacokinetics of Lisinopril, Warfarin, Digoxin, and Metformin in Healthy Subjects. Clin Pharmacokinet. 2019 Sep;58(9):1193-1203. doi: 10.1007/s40262-019-00756-2.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	LISINOPRIL ANHYDROUS	Small molecule	20 mg	Oral
Subject	Semaglutide	Peptide	20 mg	Oral
Subject	Warfarin	Small molecule	5 mg	Oral

A Trial Investigating the Influence of Oral Semaglutide on the Pharmacokinetics of Lisinopril and Warfarin in Healthy Subjects

Summary

Timeline

Publications

Drugs

Indications