Drugs / Warfarin
last change Aug 2026 re-read 2 minutes ago

Warfarin

Small molecule targets VKORC1

Developed for
atrial fibrillation · venous thromboembolism · pulmonary embolism · thrombotic disease · cirrhosis of liver · portal vein thrombosis · stroke disorder · heart failure
+50 more · heart valve disorder · atrial flutter · blood coagulation disease · cardiac valvular defect · coronary artery disorder · diabetes mellitus · end stage renal failure · heart disorder · myocardial infarction · peripheral vascular disease · acute coronary syndrome · acute myocardial infarction · aortic valve insufficiency · aortic valve stenosis · arterial occlusion · atherosclerosis · cerebral sinovenous thrombosis · chronic obstructive pulmonary disease · fibrotic liver disease · heparin-induced thrombocytopenia · ischemic stroke · isolated mesenteric vein thrombosis · malignant pancreatic neoplasm · metachromatic leukodystrophy · mitral valve disorder · myocardial ischemia · osteoarthritis, knee · pregnancy disorder · transient ischemic attack · antiphospholipid syndrome · brain infarction · brain ischemia · cardiomyopathy · carotid artery dissection · cervical artery dissection · chronic thromboembolic pulmonary hypertension · coronary aneurysm · dementia · idiopathic membranous glomerulonephritis · idiopathic pulmonary fibrosis · Kawasaki disease · May-Thurner syndrome · mitral valve stenosis · oligohydramnios · persistent atrial fibrillation · pregnancy loss, recurrent, 4 · pulmonary hypertension · rheumatic heart disease · systemic lupus erythematosus · vertebral artery dissection
Investigated by
Eli Lilly and Company · Boehringer Ingelheim · AstraZeneca · GlaxoSmithKline · Janssen Research & Development, LLC · National Heart, Lung, and Blood Institute (NHLBI)
+217 more · Sanofi · Bial - Portela C S.A. · Jiangsu HengRui Medicine Co., Ltd. · Novo Nordisk A/S · Pfizer · Abbott · Bristol-Myers Squibb · Canadian Institutes of Health Research (CIHR) · Hadassah Medical Organization · Hamilton Health Sciences Corporation · Hoffmann-La Roche · Institute for Clinical and Experimental Medicine · Massachusetts General Hospital · Novartis Pharmaceuticals · Population Health Research Institute · The First Affiliated Hospital with Nanjing Medical University · University of Alberta · University of Padova · AbbVie · Agency for Healthcare Research and Quality (AHRQ) · Astellas Pharma Europe B.V. · Bayer · Brigham and Women's Hospital · Cedars-Sinai Medical Center · China National Center for Cardiovascular Diseases · Daiichi Sankyo · Guangdong Raynovent Biotech Co., Ltd · Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd. · Heart and Stroke Foundation of Canada · Intermountain Health Care, Inc. · Kowa Research Institute, Inc. · McMaster University · Medivation, Inc. · Qilu Hospital of Shandong University · Shanghai Zhongshan Hospital · University of Edinburgh · University of Sao Paulo General Hospital · University of Texas Southwestern Medical Center · Yangzhou University · Aalborg University Hospital · Aarhus University Hospital · Abbott Medical Devices · Academia Sinica, Taiwan · Achillion, a wholly owned subsidiary of Alexion · Air Force Military Medical University, China · Akcea Therapeutics · Alexion Pharmaceuticals, Inc. · Altimmune, Inc. · Amgen · Anand, Sonia, M.D. · Aragon Pharmaceuticals, Inc. · Asan Medical Center · Assiut University · Astellas Pharma Global Development, Inc. · Astellas Pharma Inc · Avance Clinical Pty Ltd. · Azienda Ospedaliera Universitaria Policlinico · Basilea Pharmaceutica International Ltd · BeiGene · Beijing QL Biopharmaceutical Co.,Ltd · BioInvent International AB · Boryung Pharmaceutical Co., Ltd · BrightGene Bio-Medical Technology Co., Ltd. · British Thoracic Society · CSPC ZhongQi Pharmaceutical Technology Co., Ltd. · Canadian Stroke Prevention Intervention Network · Cancer Research Campaign Clinical Trials Centre · Carmel Medical Center · Celerion · Celgene Corporation · Chang Gung Memorial Hospital · Chief Scientist Office of the Scottish Government · Children Hospital and Institute of Child Health, Lahore · China Medical University Hospital · all 223 on the full record

Regulatory milestones approvals, filings & regulatory actions · 3 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Label expansions (2) US (FDA) COUMADIN 1994-03-31 – 1995-04-28 fda.gov
Approved US (FDA) COUMADIN 1954-06-08 fda.gov

Trials 229 · started per year

today
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PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 03 trials
Phase 0 NCT07011095 Sep 2025 → Feb 2027 expected atrial fibrillation Population Health Research Institute Not yet recruiting No outcome recorded
Phase 0 NCT05891119 Jun 2023 → Aug 2024 atopic eczema Amgen Completed No outcome recorded
Phase 0 NCT03536208 May 2019 → Jun 2021 malignant pancreatic neoplasm University of Texas Southwestern Medical Center Withdrawn No outcome recorded
Phase 1114 trials
Phase 1 NCT07710768 Jul 2026 → Apr 2027 expected obesity disorder Novo Nordisk A/S Not yet recruiting No outcome recorded
Phase 1 NCT07665723 Jun 2026 → Jul 2027 expected ulcerative colitis Hoffmann-La Roche Recruiting No outcome recorded
Phase 1 NCT07550816 May → Dec 2026 expected obesity disorder Beijing QL Biopharmaceutical Co.,Ltd Recruiting No outcome recorded
Phase 1 NCT07502001 Apr → Dec 2026 expected obesity disorder Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd. Not yet recruiting No outcome recorded
Phase 1 NCT07128888 Nov 2025 → Jul 2026 overdue obesity disorder Gan & Lee Pharmaceuticals. Recruiting No outcome recorded
Phase 1 NCT07331389 Sep 2025 → Jan 2026 overdue Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd. Recruiting No outcome recorded
Phase 1 NCT06975605 May → Jul 2025 isolated focal cortical dysplasia, tuberous sclerosis GRIN Therapeutics, Inc. Completed No outcome recorded
Phase 1 NCT07068841 May → Jun 2025 Neurodawn Pharmaceutical Co., Ltd. Completed No outcome recorded
Phase 1 NCT07362030 Apr → Dec 2025 overdue obesity disorder Guangdong Raynovent Biotech Co., Ltd Active not recruiting No outcome recorded
Phase 1 NCT06920056 Mar → Jul 2025 obesity disorder BrightGene Bio-Medical Technology Co., Ltd. Completed No outcome recorded
Show all 114 trials opens the full record — a long page
Phase 210 trials
Phase 2 NCT07246005 Dec 2026 → Dec 2027 expected thrombotic disease Queen Mary University of London Not yet recruiting No outcome recorded
Phase 2 NCT04562116 Dec 2021 → Jun 2023 atopic eczema Galderma R&D Completed No outcome recorded
Phase 2 NCT03987711 Dec 2019 → Dec 2022 atrial fibrillation, end stage renal failure Unity Health Toronto Completed No outcome recorded
Phase 2 NCT02450682 Feb 2016 → Jan 2017 atrial fibrillation Mayo Clinic Withdrawn No outcome recorded
Phase 2 NCT01348074 Apr 2011 → Dec 2013 atrial fibrillation, heart valve disorder, venous thromboembolism McMaster University Completed No outcome recorded
Phase 2 NCT00684307 Feb 2007 → Jun 2008 atrial fibrillation AstraZeneca Completed No outcome recorded
Phase 2 NCT00244725 Sep 2005 → Sep 2006 atrial fibrillation, pulmonary embolism, venous thromboembolism GlaxoSmithKline Completed No outcome recorded
Phase 2 NCT00180674 Aug 2005 → Sep 2006 fibrotic liver disease Imperial College London Completed No outcome recorded
Phase 2 NCT00216866 Sep 2002 → Mar 2006 venous thromboembolism London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's Completed No outcome recorded
Phase 2 NCT00014352 Sep 2000 → Mar 2003 prostate cancer, thrombotic disease Memorial Sloan Kettering Cancer Center Completed No outcome recorded
Phase 2/31 trial
Phase 2/3 NCT00201461 Jun 2003 → Apr 2010 patent foramen ovale, transient ischemic attack NMT Medical Unknown No outcome recorded
Phase 324 trials
Phase 3 NCT06045858 Oct 2024 → Oct 2027 expected atrial fibrillation University Hospital, Caen Not yet recruiting No outcome recorded
Phase 3 NCT03764241 Feb 2020 → Mar 2022 ST-elevation myocardial infarction, thrombotic disease RenJi Hospital Unknown No outcome recorded
Phase 3 NCT03636295 Sep 2019 → Dec 2026 expected venous thromboembolism Population Health Research Institute Recruiting No outcome recorded
Phase 3 NCT03153150 Mar 2018 → Mar 2021 atrial fibrillation, atrial flutter, intracerebral hemorrhage, subarachnoid hemorrhage University of Edinburgh Completed No outcome recorded
Phase 3 NCT02798471 Mar 2017 → May 2022 pulmonary embolism, venous thromboembolism Daiichi Sankyo Completed No outcome recorded
Phase 3 NCT03147638 Jan 2017 → Jan 2019 heparin-induced thrombocytopenia Marshall University Unknown No outcome recorded
Phase 3 NCT01006733 Mar 2011 → Oct 2016 thrombotic disease Washington University School of Medicine Completed No outcome recorded
Phase 3 NCT01285661 Mar 2010 → Oct 2015 venous thromboembolism University of Padova Completed No outcome recorded
Phase 3 NCT01178034 Oct 2009 → Oct 2012 atrial fibrillation University of Padova Completed No outcome recorded
Phase 3 NCT02065388 Sep 2009 → Dec 2013 atrial fibrillation, atrial flutter, stroke disorder, venous thromboembolism Academia Sinica, Taiwan Completed No outcome recorded
Phase 444 trials
Phase 4 NCT07081035 Oct 2025 → Oct 2028 expected advanced heart failure, hemorrhagic disease, thrombotic disease Asan Medical Center Not yet recruiting No outcome recorded
Phase 4 NCT07515664 Jul 2025 → Aug 2026 overdue University of Michigan Recruiting No outcome recorded
Phase 4 NCT06402851 Dec 2024 → Dec 2026 expected atrial fibrillation, chronic kidney disease Hospital Sirio-Libanes Recruiting No outcome recorded
Phase 4 NCT06401616 May 2024 → Mar 2028 expected atrial fibrillation Odense University Hospital Recruiting No outcome recorded
Phase 4 NCT07571460 Mar 2024 → Mar 2025 cirrhosis of liver, portal vein thrombosis Kafrelsheikh University Completed No outcome recorded
Phase 4 NCT05375474 Jul 2023 → Dec 2025 China National Center for Cardiovascular Diseases Unknown No outcome recorded
Phase 4 NCT05782270 Apr 2023 → Sep 2025 overdue coronary artery disorder China National Center for Cardiovascular Diseases Recruiting No outcome recorded
Phase 4 NCT04907825 Mar 2023 → Aug 2025 atrial fibrillation, stroke disorder Cedars-Sinai Medical Center Completed No outcome recorded
Phase 4 NCT05300555 Jan 2021 → Jan 2022 atrial fibrillation University of Sao Paulo General Hospital Unknown No outcome recorded
Phase 4 NCT04645550 Nov 2020 → Dec 2023 cirrhosis of liver, portal hypertension, splenic disorder, venous thromboembolism Northern Jiangsu People's Hospital Completed No outcome recorded
Phase not applicable33 trials
NCT07658989 May 2026 → Jan 2030 expected cardiac valvular defect, pregnancy disorder Mount Sinai Hospital, Canada Recruiting No outcome recorded
NCT07523347 Dec 2023 → Dec 2025 cerebral sinovenous thrombosis Muhammad Aamir Latif Completed No outcome recorded
NCT05741385 Oct 2023 → Aug 2024 cirrhosis of liver Boehringer Ingelheim Completed No outcome recorded
NCT05419583 Nov 2022 → Jun 2024 myocardial infarction University of Edinburgh Completed No outcome recorded
NCT04482842 Dec 2020 → Aug 2021 stroke disorder First Affiliated Hospital Xi'an Jiaotong University Withdrawn No outcome recorded
NCT03885180 Mar 2019 → Mar 2021 heart valve disorder, hyperheparinemia Wuhan Asia Heart Hospital Unknown No outcome recorded
NCT04164693 Jan 2019 → Sep 2022 thrombotic disease First Affiliated Hospital of Chongqing Medical University Completed No outcome recorded
NCT03781258 Nov 2018 → Dec 2021 heart failure Institute for Clinical and Experimental Medicine Unknown No outcome recorded
NCT03704220 Aug 2018 → Dec 2021 heart failure Institute for Clinical and Experimental Medicine Unknown No outcome recorded
NCT03483207 Apr 2018 → Dec 2019 isolated mesenteric vein thrombosis Assiut University Unknown No outcome recorded
Also used as a comparator or background therapy in 205 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 03 trials
Phase 0 NCT06615596 Comparator Aug 2025 → Jan 2029 expected atrial fibrillation China National Center for Cardiovascular Diseases Recruiting No outcome recorded
Phase 0 NCT06145269 Comparator Dec 2023 → Apr 2025 venous thromboembolism Assiut University Unknown No outcome recorded
Phase 0 NCT02331095 Background Jan 2015 → Oct 2017 venous thromboembolism Ohio State University Terminated No outcome recorded
Phase 110 trials
Phase 1 NCT03347968 Comparator Nov 2017 → Apr 2018 MedImmune LLC Completed No outcome recorded
Phase 1 NCT01518231 Comparator Jan → Dec 2012 stroke disorder Zhejiang Hospital Unknown No outcome recorded
Phase 1 NCT01133366 Comparator May 2010 Kastle Therapeutics, LLC Completed No outcome recorded
Phase 1 NCT00904176 Comparator Jun → Aug 2009 type 2 diabetes mellitus AstraZeneca Completed No outcome recorded
Phase 1 NCT01507051 Background Nov 2008 → Nov 2009 venous thromboembolism Bayer Completed No outcome recorded
Phase 1/22 trials
Phase 1/2 NCT03747081 Comparator Sep 2018 → Jan 2020 cerebral sinovenous thrombosis Isfahan University of Medical Sciences Unknown No outcome recorded
Phase 1/2 NCT00790842 Background Jan 2009 → Sep 2017 plasma cell myeloma PrECOG, LLC. Terminated No outcome recorded
Phase 233 trials
Phase 2 NCT05006287 Comparator Oct 2022 → May 2024 atrial fibrillation St. Paul's Hospital, Canada Unknown No outcome recorded
Phase 2 NCT05540587 Comparator May 2022 → May 2024 atrial fibrillation, mitral valve stenosis, stroke disorder Sung-Hwan Kim Unknown No outcome recorded
Phase 2 NCT04002011 Comparator Mar 2022 → Jan 2023 bleeding disorder, vascular-type Laval University Withdrawn No outcome recorded
Phase 2 NCT04865978 Comparator Dec 2021 → Oct 2023 heart failure Palak Shah Completed No outcome recorded
Phase 2 NCT03684564 Comparator Jul 2021 → Jul 2025 antiphospholipid syndrome, brain ischemia, ischemic stroke, systemic lupus erythematosus University College, London Completed No outcome recorded
Phase 2/37 trials
Phase 2/3 NCT03566303 Comparator Jul 2018 → Apr 2020 blood coagulation disease, heart valve disorder, stroke disorder Hospital Geral Roberto Santos Terminated No outcome recorded
Phase 2/3 NCT02889562 Comparator Sep 2016 → May 2019 atrial fibrillation, stroke disorder, venous thromboembolism Sanford Health Completed No outcome recorded
Phase 2/3 NCT01868243 Comparator Aug 2013 → Sep 2014 Hospital Ana Nery Terminated No outcome recorded
Phase 2/3 NCT00927862 Comparator Aug 2008 → Dec 2010 thrombotic disease Intermountain Health Care, Inc. Completed No outcome recorded
Phase 2/3 NCT00691470 Comparator May 2008 → Jun 2009 atrial fibrillation, atrial flutter, cardiomyopathy, myocardial infarction +1 ARYx Therapeutics Unknown No outcome recorded
Phase 365 trials
Phase 3 NCT07709780 Comparator Jun 2026 → Jul 2028 expected thrombotic disease University of Arizona Recruiting No outcome recorded
Phase 3 NCT07471139 Comparator Jun 2026 → Jun 2029 expected heart failure, hemorrhagic disease, stroke disorder, thrombotic disease Columbia University Not yet recruiting No outcome recorded
Phase 3 NCT07434661 Comparator Feb 2026 → Jan 2028 expected aortic valve disorder, atrial fibrillation, cardiac valvular defect Meshalkin Research Institute of Pathology of Circulation Not yet recruiting No outcome recorded
Phase 3 NCT07456085 Comparator Nov 2025 → Apr 2027 expected heart valve disorder Rawalpindi Institute of Cardiology Enrolling by invitation No outcome recorded
Phase 3 NCT05825573 Comparator May 2023 → Feb 2025 overdue ST-elevation myocardial infarction, heart failure, thrombotic disease Nîmes University Hospital Active not recruiting No outcome recorded
Phase 460 trials
Phase 4 NCT07644247 Background Jun 2026 → Jan 2029 expected hemorrhagic disease, left ventricular failure, stroke disorder, thrombotic disease China National Center for Cardiovascular Diseases Not yet recruiting No outcome recorded
Phase 4 NCT07431762 Comparator Jun 2026 → Oct 2030 expected cardiac valvular defect Asan Medical Center Recruiting No outcome recorded
Phase 4 NCT07352358 Background Jan 2026 → Jul 2028 expected cerebral sinovenous thrombosis Xuanwu Hospital, Beijing Recruiting No outcome recorded
Phase 4 NCT05643651 Comparator Jun 2025 → Jun 2027 expected Kawasaki disease, coronary aneurysm Children's Hospital of Fudan University Recruiting No outcome recorded
Phase 4 NCT06515730 Comparator Apr 2025 → Apr 2028 expected acute myocardial infarction, thrombotic disease Karolinska Institutet Recruiting No outcome recorded
Phase not applicable25 trials
NCT07677410 Comparator Jul 2026 → Jul 2029 expected aortic valve insufficiency Shanghai Zhongshan Hospital Not yet recruiting No outcome recorded
NCT07548346 Background Jul 2026 → Jan 2029 expected cerebral sinovenous thrombosis Middle East North Africa Stroke and Interventional Neurotherapies Organization Not yet recruiting No outcome recorded
NCT04684212 Comparator Jun 2024 atrial fibrillation, stroke disorder Brian O'Neill MD Withdrawn No outcome recorded
NCT06055920 Comparator Nov 2023 → Jul 2026 overdue pulmonary embolism Inari Medical Active not recruiting No outcome recorded
NCT05701917 Comparator Jan 2023 → Jun 2026 overdue post-thrombotic syndrome, venous thromboembolism Inari Medical Recruiting No outcome recorded

Press releases naming this drug 9 releases

DateIssuerRelease
2023-09-20 Amgen AMGEN LAUNCHES PARTNERS OF CHOICE NETWORK OF EIGHT LEADING ONCOLOGY ACADEMIC CENTERS amgen.com
2017-09-13 AbbVie AbbVie Announces 25th Annual Cystic Fibrosis Scholarship Program Including 2017 Thriving Student Scholarship Contest and Blogger's Choice Award abbvie.com
2017-08-29 Pfizer Bristol-Myers Squibb and Pfizer Alliance Announce Real-World Observational Analysis of the Effectiveness and Safety of Direct Oral Anticoagulants Compared to Warfarin in Elderly Patients with Non-Valvular Atrial Fibrillation pfizer.com
2017-08-27 Pfizer Bristol-Myers Squibb and Pfizer Present Observational Real-World Data Analysis on the Effectiveness and Safety of Eliquis® (apixaban) Compared to Warfarin in Select High-Risk Patients with Non-Valvular Atrial Fibrillation pfizer.com
2017-03-17 Pfizer Bristol-Myers Squibb and Pfizer Present Large Real-World Observational Analysis of the Effectiveness and Safety of Direct Oral Anticoagulants Compared to Warfarin in Patients with Non-Valvular Atrial Fibrillation pfizer.com
2013-12-10 Daiichi Sankyo Phase 3 Data Show Daiichi Sankyo’s Once-Daily Edoxaban Lowered Incidence of VTE Recurrence and Clinically Relevant Bleeding Compared to Warfarin in a Large Subgroup of Patients with Cancer daiichisankyo.com
2013-11-20 Daiichi Sankyo Daiichi Sankyo´s Once-Daily Edoxaban Meets Primary Efficacy Endpoint for Stroke Prevention and Superiority for the Principal Safety Endpoint Compared to Warfarin for Patients with Atrial Fibrillation in a Phase 3 Clinical Trial daiichisankyo.com
2013-09-01 Daiichi Sankyo Daiichi Sankyo’s Once-Daily Edoxaban Shows Comparable Efficacy and Superiority for the Principal Safety Endpoint Compared to Warfarin in a Phase 3 Study for the Treatment of Symptomatic VTE and Prevention of its Recurrence daiichisankyo.com
2008-12-08 Daiichi Sankyo NEW PHASE II DATA SHOW SAFETY OF ONCE-DAILY ORAL FACTOR Xa INHIBITOR, DU-176b, COMPARABLE TO WARFARIN IN PATIENTS WITH NON-VALVULAR ATRIAL FIBRILLATION daiichisankyo.com

Evidence & citations 35 cited values

Every value below carries the sentence it was read from. 436 sources stand behind the page.

FieldValueCited text
Known as warfarin “After discharge, these patients were switched to oral low-dose warfarin for anticoagulation, with a daily dose of 1.25mg (half tablet) on dialysis days, and 2.5mg/day on...” NCT04164693
416

“Participants in the continuation arm will receive oral anticoagulant drugs such as dabigatran, rivaroxaban, apixaban, warfarin, etc. tailored to their specific risk profiles.” NCT06615596

“Drug cocktail comprise of midazolam (2 mg), warfarin (10 mg), vitamin K (10 mg), omeprazole (40 mg), and fexofenadine (30 mg) will be administered on Study Day 1 and 43.” NCT02592317

“Including warfarin with targeted INR 2.0-3.0 (Shanghai Xinyi pharma co., LTD, China), aspirin 100 mg q.d. (Bayer, Germany) and clopidogrel 75 mg q.d. (Sanofi, France)” NCT03234114

“followed by oral anticoagulation with warfarin (target INR 2.0-3.0) or direct oral anticoagulants (DOACs) for 3-12 months as per current AHA/ASA and ESO guidelines.” NCT07548346

“Antithrombotic agents include, but are not limited to: warfarin (titrated to international normalised ratio, INR), apixaban, rivaroxaban, aspirin, and clopidogrel.” NCT05622500

“Single dose of drug cocktail: 100 milligram (mg) caffeine,10 mg warfarin, 30 mg dextromethorphan, and 0.2 mg midazolam administered orally on Day 1 in Period 1.” NCT02688088

“Branded warfarin sodium tablets (manufacturer União Química Farmacêutica Nacional S/A, Brazil) by mouth; dose adjusted according to INR and medical judgement.” NCT02017197

“subcutaneous enoxaparin followed by a vitamin K antagonist (either warfarin or acenocoumarol) for 3, 6, or 12 months in patients with acute, symptomatic DVT” PMID 21128814 Dec 2010

“the VKA type (eg, warfarin, acenocoumarol, phenprocoumon, fluindione, etc) will be assigned by the investigator according to local treatment standards” NCT01674647

“Co-administered drugs include: - Warfarin - 10 mg tablets, midazolam 1 mg, digoxin 0.25 mg, rosuvastatin 10 mg, omeprazole 20 mg, Vitamin K - 10 mg.” NCT06975605

“Beta Blockers, ACE inhibitor or ARB, loop diuretics and/or spironolactone as appropriate, statin if indicated, aspirin and/or warfarin if indicated” NCT01953874

“Based on the significant flow disturbances within the ectatic segments, chronic anticoagulation with warfarin as main therapy was suggested” NCT03896321

“VKA study medications (Warfarin, Fluindione and Acenocoumarol) will be prescribed and supplied in the usual setting of patient care” NCT05825573

Warfarin is a standard anticoagulation in the treatment for venous thromboembolism. The dose will be adjusted to goal INR of 2-3.” NCT02331095

“probe drugs will be oral midazolam (3 mg), warfarin (10 mg), omeprazole (40 mg), caffeine (200 mg), and dextromethorphan (30 mg).” NCT00401583

“Single administration on Day 13 of cocktail of CYP450 substrates: warfarin tablet, omeprazole capsule and caffeine oral solution” NCT02623296

“Repaglinide 0.25 mg, caffeine 100 mg, warfarin 10 mg (with vitamin K), omeprazole 40 mg, dextromethorphan 30 mg, midazolam 2 mg” NCT04233437

“AIM: To determine the efficacy and safety of warfarin resumption with loading doses or with the most recent maintenance dose.” PMID 24837794 Jun 2014

“Drug cocktail consists of caffeine, warfarin plus vitamin K, omeprazole, dextromethorphan, and midazolam, administered orally” NCT03718884

“Drug cocktail (caffeine, warfarin + vitamin K, omeprazole, dextromethorphan, midazolam) orally once daily, day 1 and day 20” NCT01001299

“Low-molecular-weight heparin bridging to warfarin 3 mg/day, rivaroxaban 10-20 mg/day or dabigatran 110-150 mg twice daily.” NCT07352358

“i.e. warfarin; the selection of the anticoagulant agent will be based on the clinical scenario, contraindications etc” NCT05122780

“Patients will be anticoagulated following with 30 mg QD edoxaban or adjusted dose warfarin for a target INR 2.0-3.0.” NCT06402851

“oral dose of the Cooperstown Cocktail (midazolam, omeprazole, warfarin, caffeine, and dextromethorphan)” NCT02434861

Warfarin was administered orally at a dose of 1mg per day for a year,then gradually reduced to stop.” NCT03866681

“treated with vitamin K antagonists (either warfarin or acenocoumarol) for a minimum of 3 months” NCT00264277

“Comparison of the Efficacy of Rivroxaban to Coumadin( Warfarin ) in Cerebral Venous Thrombosis” NCT03191305

“customizing a popular blood thinner (warfarin) to each person's genetic and clinical profile” NCT01006733

Warfarin for 6 months followed by antiplatelet agents is recommended as medical treatment.” PMID 21356042 Feb 2011

warfarin (INR 2.0-2.5) will be applied for 3 months unless severe safety outcome occur.” NCT03764241

“BGB-3111 and Drug Cocktail (midazolam, warfarin, omeprazole, digoxin and rosuvastatin)” NCT03561298

Warfarin and midazolam will be co-administered alone and in combination with ZSP1273.” NCT05942365

Warfarin (10 mg + 10 mg vitamin K orally) with collection of plasma over 96 hours.” NCT00164112

“Caffeine + Warfarin (plus vitamin K) + Omeprazole + Dextromethorphan + Midazolam” NCT02993471

“OAC drugs used: Dabigatran etexilate, Rivaroxaban, Warfarin, other approved VKA” NCT00559988

“Discontinuation of warfarin, dabigatran, rivaroxaban, apixaban or edoxaban” NCT06401616

“15 mg single dose of warfarin (oral tablet) will be given to patients.” NCT01769768

warfarin, dabigatran etexilate, rivaroxaban, apixaban, edoxaban usage” NCT01924065

“To demonstrate that apixaban is safer than warfarin at 1 year” PMID 39306346 Sep 2024

“CYP1A2 (caffeine 100 mg), CYP2C9 (warfarin 10 mg), CYP2C19” PMID 39707077 Dec 2024

Warfarin is allowed to use at the physicians' discretion.” NCT04250116

“aspirin (325 mg daily) and/or warfarin (target INR = 2.5)” NCT00201461

“aspirin100mg qd+clopidogrel75mg qd+warfarin (INR1.8-2.2)” NCT03415386

warfarin, dabigatran, rivaroxaban, apixaban, or edoxaban” NCT03062319

“Anticoagulation therapy includes heparin and warfarin.” NCT02485184

“We included two patient cohorts treated with warfarinPMID 26050796 Jun 2015

“An example of this type is Warfarin (Coumadin).” NCT02100228

“Vitamin K antagonists (e.g warfarin)+/- LDA” NCT07658989

warfarin and novel oral anticoagulants” NCT03126214

“Dose adjusted Coumadin (warfarin)” NCT00691470

“Vitamin-K antagonists (warfarin)” NCT05375474

“OAC includes warfarin or NOAC.” NCT01962545

Warfarin (Coumadin, Jantoven)” NCT03465735

Warfarin/Coumadin” NCT02701062

Warfarin/heparin” NCT03395639

Warfarin/heparin” NCT02798471

“Drug: WarfarinNCT01636557

warfarinNCT01164046

warfarinNCT04907825

WarfarinNCT07011095

WarfarinNCT02981472

WarfarinNCT02942576

warfarinNCT00645853

NCT03536208

NCT00618579

NCT01994265

NCT00767559

NCT00726726

NCT00800137

NCT00787150

NCT07471139

NCT02522221

NCT04855110

NCT03747081

NCT00781391

NCT02913326

NCT02426060

NCT02641899

NCT06449469

NCT03483207

NCT01991951

NCT04258488

NCT01452568

NCT03196349

NCT04994119

NCT01516814

NCT03781258

NCT01452347

NCT05995600

NCT01695824

NCT01227629

NCT03792152

NCT05602675

NCT02704598

NCT06145269

NCT00000614

NCT03536611

NCT02340988

NCT05480488

NCT02243553

NCT02836652

NCT01147731

NCT00925028

NCT04972396

NCT02240953

NCT00247702

NCT01340846

NCT06738992

NCT04645550

NCT00479362

NCT00014352

NCT01516840

NCT07456085

NCT02042534

NCT00265408

NCT01561937

NCT00334464

NCT07677410

NCT03234699

NCT01111331

NCT00216866

NCT04676035

NCT04173429

NCT03232398

NCT05300555

NCT00162435

NCT00041938

NCT03839355

NCT00329238

NCT04066764

NCT03807921

NCT07550816

NCT00004728

NCT02561897

NCT02526303

NCT00673439

NCT04067505

NCT03636295

NCT02240927

NCT01507051

NCT07404436

NCT04246762

NCT00162474

NCT00262600

NCT00938132

NCT02238535

NCT02238444

NCT01431690

NCT01475279

NCT00365950

NCT00235248

NCT03702582

NCT03347968

NCT06920056

NCT00000539

NCT01477424

NCT04073316

NCT01133366

NCT00966290

NCT00182104

NCT02452918

NCT05782270

NCT04045093

NCT02398357

NCT01780987

NCT02169440

NCT00180674

NCT06723691

NCT00504556

NCT00000517

NCT06289504

NCT00024297

NCT04709094

NCT01388335

NCT03490994

NCT03185845

NCT01311622

NCT00001713

NCT01199341

NCT02318342

NCT02348723

NCT03147638

NCT00448214

NCT02065388

NCT03704220

NCT03088072

NCT01520402

NCT04569279

NCT00814177

NCT00643201

NCT03885180

NCT02334254

NCT01034124

NCT04970576

NCT00595426

NCT00097357

NCT03673605

NCT07515664

NCT05891119

NCT02853526

NCT02046460

NCT01986192

NCT00091299

NCT02422589

NCT02772601

NCT05705089

NCT02002611

NCT01130025

NCT02164864

NCT00689637

NCT00986154

NCT07434661

NCT00680186

NCT00000463

NCT02492230

NCT00914667

NCT00993200

NCT00957242

NCT00683189

NCT01136408

NCT04684212

NCT02696226

NCT03058419

NCT02531568

NCT06772779

NCT02247414

NCT00245856

NCT05973188

NCT01597310

NCT04235569

NCT01214122

NCT00377143

NCT00157651

NCT07068841

NCT01911728

NCT02982850

NCT02206815

NCT05208398

NCT02744092

NCT03463317

NCT02397382

NCT00007683

NCT04482842

NCT00404274

NCT00721136

NCT01178853

NCT02303171

NCT02024230

NCT02646267

NCT07644247

NCT07710768

NCT03987711

NCT02090075

NCT01036802

NCT00199602

NCT01400646

NCT01657825

NCT00623987

NCT00742859

NCT03183843

NCT02647086

NCT04142658

NCT02779348

NCT02461914

NCT01758640

NCT05392127

NCT00806624

NCT02780622

NCT05794399

NCT00070655

NCT01432938

NCT05419583

NCT00401414

NCT02054936

NCT02392104

NCT03153150

NCT07709780

NCT02617810

NCT07362030

NCT00345618

NCT07077954

NCT01287598

NCT00062803

NCT02740712

NCT02889562

NCT02719431

NCT02022527

NCT00412984

NCT02161965

NCT00927862

NCT00428441

NCT00580216

NCT01505881

NCT02022254

NCT07246005

NCT02303795

NCT02161731

NCT02345304

NCT02287415

NCT07523347

NCT06335134

NCT01263119

NCT00938730

NCT00964353

NCT02810704

NCT07571460

NCT05815680

NCT01391962

NCT01246011

NCT00380120

NCT00827034

NCT01518231

NCT00027066

NCT01103609

NCT02544932

NCT03358706

NCT00895505

NCT02070510

NCT00511173

NCT03217448

NCT04730037

NCT05273775

NCT01668901

NCT02982590

NCT02450682

NCT02305030

NCT02783040

NCT05643651

NCT00829933

NCT01178034

NCT00621491

NCT01250535

NCT00856570

NCT00904176

NCT05540587

NCT03566303

NCT02283294

NCT05006287

NCT03862859

NCT07128888

NCT02630095

NCT07665723

NCT01182441

NCT04887194

NCT04865978

NCT01727453

NCT02376803

NCT01438580

NCT03181386

NCT01447511

NCT00438230

NCT02295475

NCT03061006

NCT04976543

NCT00740883

NCT00403767

NCT02935855

NCT00777855

NCT02183389

NCT04727437

NCT00494871

NCT01868243

NCT03926780

NCT00533026

NCT03556592

NCT03363815

NCT00129545

NCT01747746

NCT02227550

NCT00356759

NCT02376010

NCT00740493

NCT01195324

NCT00662467

NCT03926156

NCT02506985

NCT02072434

NCT00125671

NCT00973323

NCT07331389

NCT01124058

NCT01569035

NCT04002011

NCT06215430

NCT02979561

NCT02540668

NCT02094157

NCT01317927

NCT03684564

NCT02182336

NCT00973245

NCT02942407

NCT06655376

NCT03244319

NCT00870298

NCT06686628

NCT07502001

NCT01825876

NCT02254148

NCT07081035

NCT00487136

NCT03426033

NCT07431762

NCT03078374

NCT00634907

NCT00291330

NCT00697151

NCT02252731

NCT00238667

NCT06515730

NCT03245307

NCT04121767

NCT05445232

NCT02375646

NCT00004054

NCT01662908

Known as acecoumaril ClinicalTrials.gov intervention name — accepted as the source's own label NCT02227550
Known as Aldocumar ChEMBL registry synonym — accepted as the source's own label CHEMBL1464
Known as Apo-warfarin ChEMBL registry synonym — accepted as the source's own label CHEMBL1464
Known as Athrombin ChEMBL registry synonym — accepted as the source's own label CHEMBL1464
Known as Athrombin-k ChEMBL registry synonym — accepted as the source's own label CHEMBL1464
Known as Choice ChEMBL registry synonym — accepted as the source's own label CHEMBL1464
Known as Coumadin “Market approved oral anticoagulation (OAC), such as warfarin (Coumadin), dabigatran (Pradaxa), rivaroxaban (Xarelto), apixiban (Eliquis), edoxaban (Savaysa), or betrixaban (Bevyxxa)” NCT04684212
21

“Prophylactic Coumadin® by oral administration at a fixed dose of 2.5 mg to prevent thromboembolic events (DVT and TIA/stroke) during Thalidomide administration.” NCT00450008

“Commercially available/market approved anticoagulation medication including but not limited to: Heparin Sodium, Coumadin, Rivaroxaban, Apixaban, etc.” NCT06055920

“If patient is unable to tolerate aspirin, patient should receive other types of anti-coagulation like Coumadin or low molecular weight heparin.” NCT01042704

“Heparin, low molecular weight heparin, or coumadin could be used if the patient was intolerant to aspirin.” NCT00790842

“the FDA approved the label change of warfarin/Coumadin™ to recommend considering lower initial doses” NCT01006733

“Warfarin (also called Coumadin®) is an anticoagulant drug (blood thinner)” NCT00377143

“an anticoagulation medicine called warfarin (Coumadin®)” NCT00634907

“warfarin (Coumadin, Bristol Myers Squibb) for 3 months” NCT00438230

“An example of this type is Warfarin (Coumadin).” NCT02100228

“Warfarin (Coumadine): INR target \[2.0-3.0\]” NCT06045858

“warfarin (Coumadin, Bristol Myers Squibb)” NCT00623987

“Drug: Warfarin (Coumadin)” NCT01507051

“Warfarin or coumadinNCT00800137

“Warfarin (Coumadin)” NCT02054936

NCT05701917

NCT00484640

NCT03191305

NCT00691470

NCT01006876

NCT04679948

NCT00244725

Known as Coumadine “Warfarin (Coumadine): INR target \[2.0-3.0\]” NCT06045858
Known as Jantoven ChEMBL registry synonym — accepted as the source's own label CHEMBL1464
Known as Marevan “If the patient has already been prescribed Marevan before the aortic valve intervention, the patient will continue this medication following the procedure as an oral...” NCT06449469
2

“We aim to determine, through mean INR difference between formulations, whether there is therapeutic equivalency between the branded warfarin sodium (Marevan®) and the generic...” NCT02017197

“comparison between 2 drug, (rivaroxaban) and Marevan (warfarin)” NCT06145269

Known as NSC-59813 ChEMBL registry synonym — accepted as the source's own label CHEMBL1464
Known as Orfarin “Warfarin (Orfarin®) is the most popular vitamin K antagonist” NCT04569279
Known as Panwarfin ChEMBL registry synonym — accepted as the source's own label CHEMBL1464
Known as Potassium warfarin ChEMBL registry synonym — accepted as the source's own label CHEMBL1464
Known as Prothromadin ChEMBL registry synonym — accepted as the source's own label CHEMBL1464
Known as Sodium warfarin ClinicalTrials.gov intervention name — accepted as the source's own label NCT01285661
Known as Varfine Varfine® 5 mg (warfarin 5 mg) tablets” NCT02779348
Known as Vitamin K antagonists (VKA) ClinicalTrials.gov intervention name — accepted as the source's own label NCT02832544
Known as Vitamin-K antagonist at INR 2-3 ClinicalTrials.gov intervention name — accepted as the source's own label NCT00684307
Known as Warfarin (Coumadin, Jantoven) Warfarin (Coumadin, Jantoven)NCT03465735
Known as Warfarin (Marevan) “Warfarin (Marevan®) is available as 1mg (brown), 3 mg (blue) and 5 mg (pink) oral tablets from GlaxoSmithKline Pte. Ltd.” NCT00700895
Known as WARFARIN POTASSIUM ChEMBL registry synonym — accepted as the source's own label CHEMBL1464
Known as Warfarin Sodium “CYP substrates (Caffeine, Warfarin Sodium, Midazolam, Omeprazole, and Metoprolol Tartrate) will administered orally at Week 0 (Day 1) and Week 10 as per the commercially...” NCT04562116
8

“SHR0302 Tablets + probe drugs (Midazolam Maleate Tablets + Warfarin Sodium Tablets+ Omeprazole Enteric Capsules+ Repaglinide Tablets) + Vitamin K1 Tablets” NCT05392127

“Warfarin was dosed as 2 x 10 mg and 1 x 5 mg warfarin sodium tablets (Coumadin or generic equivalent).” NCT04709094

“two tablets of warfarin sodium (5mg)” NCT07362030

“Drug: Warfarin Sodium 5 MG” NCT04235569

NCT05741385

NCT00700895

NCT05045313

NCT02256813

Known as Warfarin sodium salt ChEMBL registry synonym — accepted as the source's own label CHEMBL1464