Improving Stroke Prevention in Atrial Fibrillation Through Pharmacist Prescribing

Phase 4 Completed 79 enrolled University of Alberta Canadian Stroke Prevention Intervention Network · collab Heart and Stroke Foundation of Canada · collab

RandomizedCrossoverOpen-labelPrevention

Summary

The purpose of this study is to compare the effectiveness of prescribing oral anticoagulation therapy by pharmacist intervention compared to enhanced usual care in participants with unrecognized AF and/or known AF but not taking blood thinners.

Timeline

Start: 2018-02-01
Primary completion: 2022-07-01
Completion: 2023-12-01

Outcome

Met primary endpoint

paper Guideline-concordant OAC use at 3 months occurred in 36 of 39 patients (92.3%) in the early intervention group vs 23 of 41 (56.1%) PMID 39046741 ↗

paper vs 23 of 41 (56.1%) in the control group (P < .001) PMID 39046741 ↗

Publications

Sandhu RK, Fradette M, Lin M, Youngson E, Lau D, Bungard TJ, Tsuyuki RT, Dolovich L, Healey JS, McAlister FA. Stroke Risk Reduction in Atrial Fibrillation Through Pharmacist Prescribing: A Randomized Clinical Trial. JAMA Netw Open. 2024 Jul 1;7(7):e2421993. doi: 10.1001/jamanetworkopen.2024.21993.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Warfarin	Small molecule	—	Oral