Effect of Liraglutide on Gastrointestinal Absorption of Several Drugs and Potential Influence of Liraglutide on Intragastric pH

Phase 1 Completed 70 enrolled Novo Nordisk A/S

RandomizedCrossoverDouble-blindTreatment

Summary

The trial is conducted in Europe. The aim of the trial is to investigate if there is any drug to drug interaction between liraglutide and atorvastatin (Lipitor®), lisinopril (Zestril®), griseofulvin and digoxin (Lanoxin®).

Timeline

Start: 2006-05
Primary completion: 2007-04
Completion: 2007-04

Publications

Results Malm-Erjefalt M, Ekblom M, Vouis J, Zdravkovic M, Lennernas H. Effect on the Gastrointestinal Absorption of Drugs from Different Classes in the Biopharmaceutics Classification System, When Treating with Liraglutide. Mol Pharm. 2015 Nov 2;12(11):4166-73. doi: 10.1021/acs.molpharmaceut.5b00278. Epub 2015 Oct 12.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Atorvastatin	Small molecule	40 mg	Oral
Subject	Digoxin	Other / unclassified	1 mg	Oral
Subject	Griseofulvin	Small molecule	500 mg	Oral
Subject	LISINOPRIL ANHYDROUS	Small molecule	20 mg	Oral
Subject	Liraglutide	Peptide	1.8 mg	Subcutaneous

Effect of Liraglutide on Gastrointestinal Absorption of Several Drugs and Potential Influence of Liraglutide on Intragastric pH

Summary

Timeline

Publications

Drugs

Indications