Drugs / Felodipine
Felodipine
also known as
Plendil · C08CA02 · Cabren · Cardioplen xl · Felodipine component of lexxel · Felodipine Controlled Release Tablets · Felodipine Modified-release Tablets · Felodipine sustained release tablets · +14 more
Small molecule targets NR3C2 via inhibition
Regulatory milestones approvals, filings & regulatory actions · 2 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Label expansion | US (FDA) | PLENDIL | — | 1994-09-22 | fda.gov ↗ |
| Approved | US (FDA) | PLENDIL | — | 1991-07-25 | fda.gov ↗ |
Trials 9
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 13 trials | ||||||
| Phase 1 | NCT05614037 | Oct → Nov 2022 | hypertensive disorder | Overseas Pharmaceuticals, Ltd. | Unknown | No outcome recorded |
| Phase 1 | NCT02232269 | Feb → Jun 2012 | — | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | Completed | No outcome recorded |
| Phase 1 | NCT00905333 | Oct → Nov 2008 | — | AstraZeneca | Completed | No outcome recorded |
| Phase 45 trials | ||||||
| Phase 4 | NCT04330300 | Apr 2020 → Jul 2021 | COVID-19, essential hypertension | National University of Ireland, Galway, Ireland | Suspended | No outcome recorded Stop: Business |
| Phase 4 | NCT00841880 | Jan → Sep 2009 | hypertensive disorder | Sanofi | Completed | No outcome recorded |
| Phase 4 | NCT00507845 | Jun 2007 → Apr 2008 | hypertensive disorder | Sanofi | Completed | No outcome recorded |
| Phase 4 | NCT00348686 | Jun 2006 → Jun 2008 | hypertensive disorder, hypertensive heart disease | AstraZeneca | Completed | No outcome recorded |
| Phase 4 | NCT00861016 | Oct 2005 → Apr 2006 | essential hypertension | AstraZeneca | Completed | No outcome recorded |
| Phase not applicable1 trial | ||||||
| — | NCT02336607 | Dec 2005 → Jun 2006 | hypertensive disorder | AstraZeneca | Completed | No outcome recorded |
| Comparator or background therapy8 trials | ||||||
| Phase 3 | NCT00679653 Comparator | Feb 2002 → Dec 2003 | hypertensive disorder, obesity disorder | Abbott | Completed | No outcome recorded |
| Phase 3 | NCT00000620 Background | Sep 1999 → Jun 2009 | atherosclerosis, coronary artery disorder, hyperlipoproteinemia, hypertensive disorder +1 | National Heart, Lung, and Blood Institute (NHLBI) | Completed | Missed primary |
| Phase 4 | NCT02744872 Comparator | Sep 2013 → Jul 2016 | disease related to solid organ transplantation | Rigshospitalet, Denmark | Completed | No outcome recorded |
| Phase 4 | NCT01520285 Comparator | Dec 2011 → Mar 2013 | essential hypertension | Lee's Pharmaceutical Limited | Completed | No outcome recorded |
| Phase 4 | NCT01238705 Comparator | Apr 2008 → Oct 2010 | essential hypertension, sexual disorder | LanZhou University | Unknown | No outcome recorded |
| — | NCT00742066 Comparator | Mar 2008 → Jul 2009 | essential hypertension | Maastricht University Medical Center | Unknown | No outcome recorded |
| — | NCT00684489 Comparator | Sep 2003 → Mar 2005 | essential hypertension | Medical University of South Carolina | Completed | No outcome recorded |
| — | NCT01136863 Comparator | Apr 1998 → Jun 2004 | hypertensive disorder | Chinese Academy of Medical Sciences | Completed | No outcome recorded |
News releases announcing trial results or a regulatory action · 1
| Date | Issuer | Release |
|---|---|---|
| 2012-08-21 | Wockhardt | Regulatory WOCKHARDT TO LAUNCH GENERIC VERSION OF ANTI – HYPERTENSIVE DRUG PLENDIL® wockhardt.com ↗ |
All press releases naming this drug 1 release
| Date | Issuer | Release |
|---|---|---|
| 2012-08-21 | Wockhardt | WOCKHARDT TO LAUNCH GENERIC VERSION OF ANTI – HYPERTENSIVE DRUG PLENDIL® wockhardt.com ↗ |
Evidence & citations 27 cited values
Every value below carries the sentence it was read from. 18 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Felodipine | “Amlodipine, diltiazem, felodipine, nicardipine, nifedipine, nimodipine, nitrendipine, verapamil” NCT04330300 ↗16“amlodipine, felodipine, isradipine, nicardipine, nifedipine” NCT00684489 ↗ “plendil (Felodipine)” NCT00000620 ↗ “felodipine/ramipril” NCT00679653 ↗ |
| Known as | C08CA02 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1480 ↗ |
| Known as | Cabren | ChEMBL registry synonym — accepted as the source's own label CHEMBL1480 ↗ |
| Known as | Cardioplen xl | ChEMBL registry synonym — accepted as the source's own label CHEMBL1480 ↗ |
| Known as | Felodipine component of lexxel | ChEMBL registry synonym — accepted as the source's own label CHEMBL1480 ↗ |
| Known as | Felodipine Controlled Release Tablets | “Test preparation (T) :Felodipine Controlled Release Tablets Specification: 5 mg Batch number: 22090301 Content: 100.8% Valid until: September 2024 Storage conditions: sealed,...” NCT05614037 ↗ |
| Known as | Felodipine Modified-release Tablets | “Felodipine Modified-release Tablets (trade name:plendil ®) Specification: 5 mg Batch number: 2204 a11 Content: 99.1% Valid until March 2025 Storage conditions: below 25℃...” NCT05614037 ↗ |
| Known as | Felodipine sustained release tablets | “Felodipine sustained release tablets (trade name: plendil®)” NCT05614037 ↗ |
| Known as | Felodipine sustained-release tablet | “Felodipine sustained-release tablet (5mg/tablet)” NCT01520285 ↗ |
| Known as | Felodipino | ChEMBL registry synonym — accepted as the source's own label CHEMBL1480 ↗ |
| Known as | Felogen xl | ChEMBL registry synonym — accepted as the source's own label CHEMBL1480 ↗ |
| Known as | Felotens xl | ChEMBL registry synonym — accepted as the source's own label CHEMBL1480 ↗ |
| Known as | Folpik xl | ChEMBL registry synonym — accepted as the source's own label CHEMBL1480 ↗ |
| Known as | H 154/82 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1480 ↗ |
| Known as | Keloc sr | ChEMBL registry synonym — accepted as the source's own label CHEMBL1480 ↗ |
| Known as | Neofel xl | ChEMBL registry synonym — accepted as the source's own label CHEMBL1480 ↗ |
| Known as | NSC-760343 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1480 ↗ |
| Known as | Parmid xl | ChEMBL registry synonym — accepted as the source's own label CHEMBL1480 ↗ |
| Known as | Pinefeld xl | ChEMBL registry synonym — accepted as the source's own label CHEMBL1480 ↗ |
| Known as | Plendil | “Felodipine sustained release tablets (trade name: plendil®)” NCT05614037 ↗1“Felodipine tablet (Plendil) alone” NCT02336607 ↗ |
| Known as | plendil (Felodipine) | “plendil (Felodipine)” NCT00000620 ↗ |
| Known as | Preslow | ChEMBL registry synonym — accepted as the source's own label CHEMBL1480 ↗ |
| Known as | Vascalpha | ChEMBL registry synonym — accepted as the source's own label CHEMBL1480 ↗ |
| Action | Inhibit | “Mineralocorticoid receptor antagonist” CHEMBL1480 ↗ |
| Modality | Small molecule | — CHEMBL1480 ↗ |
| Route | Oral | “5 mg once daily in oral tablet form” NCT00348686 ↗ |
| Target | NR3C2 | “Mineralocorticoid receptor antagonist” CHEMBL1480 ↗ |