drugset / Trial / NCT00000620

Action to Control Cardiovascular Risk in Diabetes (ACCORD)

Phase 3 Completed 10251 enrolled National Heart, Lung, and Blood Institute (NHLBI) Centers for Disease Control and Prevention · collab National Eye Institute (NEI) · collab National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · collab National Institute on Aging (NIA) · collab

RandomizedFactorialOpen-labelPrevention

Summary

The purpose of this study is to prevent major cardiovascular events (heart attack, stroke, or cardiovascular death) in adults with type 2 diabetes mellitus using intensive glycemic control, intensive blood pressure control, and multiple lipid management.

Timeline

Start: 1999-09
Primary completion: 2009-06
Completion: 2012-12

Publications

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Fenofibrate	Small molecule	54 mg	—
Subject	Fenofibrate	Small molecule	160 mg	—
Background	Acarbose	Unknown	—	—
Background	Benazepril	Unknown	—	—
Background	Candesartan	Unknown	—	—
Background	Carvedilol	Other / unclassified	—	—
Background	Chlorthalidone	Other / unclassified	—	—
Background	Diltiazem	Small molecule	—	—
Background	Felodipine	Small molecule	—	—
Background	Furosemide	Other / unclassified	—	—
Background	Glimepiride	Small molecule	—	—
Background	Hydralazine	Small molecule	—	—
Background	Insulin	Protein / enzyme biologic	—	—
Background	Metformin	Small molecule	—	—
Background	Metoprolol	Other / unclassified	—	—
Background	Pioglitazone	Small molecule	—	—
Background	Repaglinide	Small molecule	—	—
Background	Rosiglitazone	Small molecule	—	—
Background	Simvastatin	Small molecule	20 mg	—
Background	Simvastatin	Small molecule	40 mg	—
Background	Terazosin	Small molecule	—	—
Background	Valsartan	Small molecule	—	—
Background	amlodipine / benazepril	Unknown	—	—
Background	benazepril / hydrochlorothiazide	Unknown	—	—
Background	candesartan / hydrochlorothiazide	Unknown	—	—
Background	human 30/70	Unknown	—	—
Background	human isophane	Unknown	—	—
Background	human mixed	Unknown	—	—
Background	insulin aspart	Protein / enzyme biologic	—	—
Background	insulin detemir	Protein / enzyme biologic	—	—
Background	insulin glargine	Protein / enzyme biologic	—	—
Background	insulin isophane	Unknown	—	—
Background	lisinopril / hydrochlorothiazide	Unknown	—	—
Background	metoprolol / hydrochlorothiazide	Unknown	—	—
Background	reserpine	Small molecule	—	—
Background	triamterene / hydrochlorothiazide	Unknown	—	—
Background	valsartan / hydrochlorothiazide	Unknown	—	—

Action to Control Cardiovascular Risk in Diabetes (ACCORD)

Summary

Timeline

Publications

Drugs

Indications