drugset
Drugs / reserpine
last change Jun 2023 re-read 9 days ago

reserpine

also known as Apoplon · ENT-50146 · Hiserpia · NSC-237659 · NSC-59272 · Rau-sed · Reserpina · Reserpine component of cam-ap-es · +27 more

Small molecule targets SLC18A2 via inhibition

Developed for
hypertensive disorder · cocaine dependence · pulmonary arterial hypertension · resistant hypertension
Investigated by
National Heart, Lung, and Blood Institute (NHLBI) · National Institute on Aging (NIA) · National Institute on Drug Abuse (NIDA) · Cincinnati VA Medical Center · Mayo Clinic · University of Alabama at Birmingham

Regulatory milestones approvals, filings & regulatory actions · 1 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Approved US (FDA) SERPASIL-APRESOLINE — 1954-04-01 fda.gov ↗

Trials 6

today
US approved 1954
NCT02684786 · Ph 1 NCT03223272 · Ph 2 NCT00267657 · Ph 1 NCT00033033 · Ph 2 NCT00000514 · Ph 3 NCT00000499 · Ph 2
1953195419551956195719581959196019611962196319641965196619671968196919701971197219731974197519761977197819791980198119821983198419851986198719881989199019911992199319941995199619971998199920002001200220032004200520062007200820092010201120122013201420152016201720182019202020212022202320242025202620272028
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 12 trials
Phase 1 NCT02684786 Jul 2016 pulmonary arterial hypertension Mayo Clinic Withdrawn No outcome recorded
Phase 1 NCT00267657 Jan → Nov 2004 substance-related disorder National Institute on Drug Abuse (NIDA) Unknown No outcome recorded
Phase 23 trials
Phase 2 NCT03223272 Jul 2015 → Jan 2020 resistant hypertension University of Alabama at Birmingham Completed No outcome recorded
Phase 2 NCT00033033 Jul 2001 → May 2003 cocaine dependence National Institute on Drug Abuse (NIDA) Completed No outcome recorded
Phase 2 NCT00000499 Sep 1980 → May 1983 heart disorder, hypertensive disorder National Heart, Lung, and Blood Institute (NHLBI) Completed No outcome recorded
Phase 31 trial
Phase 3 NCT00000514 Jun 1984 → Oct 1996 cerebrovascular disorder, heart disorder, hypertensive disorder National Heart, Lung, and Blood Institute (NHLBI) Completed No outcome recorded
Comparator or background therapy3 trials
Phase 3 NCT00000620 Background Sep 1999 → Jun 2009 atherosclerosis, coronary artery disorder, hyperlipoproteinemia, hypertensive disorder +1 National Heart, Lung, and Blood Institute (NHLBI) Completed Missed primary
— NCT06199778 Background Jun 2022 → May 2023 traumatic brain injury Zeng Changhao Terminated No outcome recorded
— NCT00684489 Comparator Sep 2003 → Mar 2005 essential hypertension Medical University of South Carolina Completed No outcome recorded

Evidence & citations 40 cited values

Every value below carries the sentence it was read from. 10 sources stand behind the page.

FieldValueCited text
Known as reserpine “methyldopa, reserpine, guanfacine, hydralazine, minoxidil” NCT00684489 ↗
9

“reserpine” NCT00000620 ↗

“reserpine” NCT00000620 ↗

NCT02684786 ↗

NCT00000499 ↗

NCT00033033 ↗

NCT06199778 ↗

NCT00267657 ↗

NCT00000514 ↗

NCT03223272 ↗
Known as Apoplon ChEMBL registry synonym — accepted as the source's own label CHEMBL772 ↗
Known as ENT-50146 ChEMBL registry synonym — accepted as the source's own label CHEMBL772 ↗
Known as Hiserpia ChEMBL registry synonym — accepted as the source's own label CHEMBL772 ↗
Known as NSC-237659 ChEMBL registry synonym — accepted as the source's own label CHEMBL772 ↗
Known as NSC-59272 ChEMBL registry synonym — accepted as the source's own label CHEMBL772 ↗
Known as Rau-sed ChEMBL registry synonym — accepted as the source's own label CHEMBL772 ↗
Known as Reserpina ChEMBL registry synonym — accepted as the source's own label CHEMBL772 ↗
Known as Reserpine component of cam-ap-es ChEMBL registry synonym — accepted as the source's own label CHEMBL772 ↗
Known as Reserpine component of demi-regroton ChEMBL registry synonym — accepted as the source's own label CHEMBL772 ↗
Known as Reserpine component of diutensen-r ChEMBL registry synonym — accepted as the source's own label CHEMBL772 ↗
Known as Reserpine component of dralserp ChEMBL registry synonym — accepted as the source's own label CHEMBL772 ↗
Known as Reserpine component of h.r.-50 ChEMBL registry synonym — accepted as the source's own label CHEMBL772 ↗
Known as Reserpine component of hydralazine hydrochloride-hydrochlorothiazide- ChEMBL registry synonym — accepted as the source's own label CHEMBL772 ↗
Known as Reserpine component of hydrap-es ChEMBL registry synonym — accepted as the source's own label CHEMBL772 ↗
Known as Reserpine component of hydro-reserp ChEMBL registry synonym — accepted as the source's own label CHEMBL772 ↗
Known as Reserpine component of hydromox r ChEMBL registry synonym — accepted as the source's own label CHEMBL772 ↗
Known as Reserpine component of hydropres ChEMBL registry synonym — accepted as the source's own label CHEMBL772 ↗
Known as Reserpine component of hydroserpine plus (r-h-h) ChEMBL registry synonym — accepted as the source's own label CHEMBL772 ↗
Known as Reserpine component of metatensin ChEMBL registry synonym — accepted as the source's own label CHEMBL772 ↗
Known as Reserpine component of naquival ChEMBL registry synonym — accepted as the source's own label CHEMBL772 ↗
Known as Reserpine component of regroton ChEMBL registry synonym — accepted as the source's own label CHEMBL772 ↗
Known as Reserpine component of renese-r ChEMBL registry synonym — accepted as the source's own label CHEMBL772 ↗
Known as Reserpine component of salutensin ChEMBL registry synonym — accepted as the source's own label CHEMBL772 ↗
Known as Reserpine component of ser-a-gen ChEMBL registry synonym — accepted as the source's own label CHEMBL772 ↗