insulin detemir

also known as detemir · Levemir · IDet · NN304 · insulin Detemir: Levemir · Insulin Levemir · B29Lys(epsilon-tetradecanoyl),desB30 human insulin · B29Lys(ε-tetradecanoyl),desB30 human insulin · +6 more

Protein / enzyme biologic targets INSR via activation

Developed for: type 2 diabetes mellitus · type 1 diabetes mellitus · diabetes mellitus · gestational diabetes · Alzheimer disease · cognitive impairment with or without cerebellar ataxia · cystic fibrosis · obesity disorder
+3 more
· cystic fibrosis-related diabetes · hyperglycemia · diabetes mellitus, noninsulin-dependent, 2
Investigated by: Novo Nordisk A/S · Centre Hospitalier Universitaire Dijon · Diabetes Care Center · Lise Tarnow · The Royal Bournemouth Hospital · University Hospital Tuebingen
+51 more
· Abbott · Alzheimer's Association · Amsterdam UMC, location VUmc · Bispebjerg Hospital · CenTrial GmbH · Centre Europeen d'Etude du Diabete · Children's Hospital Colorado · Copenhagen Trial Unit, Center for Clinical Intervention Research · Emory University · First Affiliated Hospital Xi'an Jiaotong University · Frederiksberg University Hospital · Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud · Herlev Hospital · Hillerod Hospital, Denmark · Hvidovre University Hospital · Indiana University · John Hunter Children's Hospital · Lady Cilento Children's Hospital, Brisbane · McMaster University · Medical University of Graz · Medical University of Vienna · Montefiore Medical Center · Montreal Clinical Research Institute · Mountain Diabetes and Endocrine Center · National Institute on Aging (NIA) · Nationwide Children's Hospital · Newcastle University · Northumbria University · Pontificia Universidad Catolica de Chile · Rabin Medical Center · Rigshospitalet, Denmark · St George's, University of London · St. Luke's-Roosevelt Hospital Center · Steno Diabetes Center Copenhagen · Sydney Children's Hospitals Network · Thomas Jefferson University · University Hospital, Gentofte, Copenhagen · University of Aarhus · University of Bern · University of Calgary · University of California, Los Angeles · University of Minnesota · University of New Mexico · University of Padova · University of Rochester · University of Texas Southwestern Medical Center · University of Washington · Vanderbilt University · Wake Forest University Health Sciences · Women's and Children's Hospital, Adelaide · Zealand University Hospital

Regulatory milestones approvals, filings & regulatory actions · 5 recorded

Milestone	Jurisdiction	Brand	Indication	Date	Sentence it was read from
Label expansions (3)	US (FDA)	LEVEMIR FLEXTOUCH	—	2012-03-29 – 2012-05-18	fda.gov ↗
Approved	US (FDA)	LEVEMIR FLEXTOUCH	—	2005-06-16	fda.gov ↗
Approved	EU (EMA)	Levemir	—	2004-06-01	europa.eu ↗

Trials 94 · started per year

today

EU approved 2004

US approved 2005

19992000200120022003200420052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027

Phase	Registry id	Dates	Indication	Sponsor	Status	Outcome
Phase 114 trials
Phase 1	NCT05134987	Dec 2021 → May 2022	type 1 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 1	NCT00873223	Mar → Sep 2009	type 2 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 1	NCT00810589	Nov → Dec 2008	type 1 diabetes mellitus	Medical University of Graz	Completed	No outcome recorded
Phase 1	NCT01498939	Aug → Sep 2007	diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 1	NCT01490099	Aug → Nov 2006	diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 1	NCT01498926	Nov 2005 → Feb 2006	diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 1	NCT01497587	Aug → Dec 2005	diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 1	NCT01497574	May → Oct 2005	type 1 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 1	NCT01497535	May → Oct 2004	diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 1	NCT00760448	Apr 2004 → Oct 2005	type 1 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 1	NCT01497600	Feb → Aug 2004	type 2 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 1	NCT01497561	Mar → Jun 2003	type 2 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 1	NCT01542450	Aug 2002 → Feb 2003	type 1 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 1	NCT02162407	Oct → Dec 1999	diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded

Phase 24 trials
Phase 2	NCT05124457	Feb 2022 → Jun 2025 overdue	gestational diabetes, type 2 diabetes mellitus	University of California, Los Angeles	Recruiting	No outcome recorded
Phase 2	NCT01595646	Nov 2011 → Mar 2015	Alzheimer disease, cognitive impairment with or without cerebellar ataxia	Wake Forest University Health Sciences	Completed	No outcome recorded
Phase 2	NCT01547169	Mar 2011 → Dec 2012	Alzheimer disease, cognitive impairment with or without cerebellar ataxia	University of Washington	Completed	No outcome recorded
Phase 2	NCT00764556	May 2008 → May 2009	chronic obstructive pulmonary disease, hyperglycemia	St George's, University of London	Completed	No outcome recorded
Phase 2/32 trials
Phase 2/3	NCT02496780	Aug 2015 → Jul 2022	cystic fibrosis	University of Minnesota	Terminated	No outcome recorded
Phase 2/3	NCT00639626	Aug 2008 → May 2010	cystic fibrosis-related diabetes	Nationwide Children's Hospital	Terminated	No outcome recorded
Phase 334 trials
Phase 3	NCT04222348	Oct 2016 → May 2020	gestational diabetes, perinatal disease, puerperal disorder	Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud	Unknown	No outcome recorded
Phase 3	NCT01461616	Feb → Nov 2012	type 1 diabetes mellitus	University of Aarhus	Completed	No outcome recorded
Phase 3	NCT01513473	Jan 2012 → Jul 2013	type 1 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 3	NCT01100892	Dec 2010 → Feb 2023	cystic fibrosis, diabetes mellitus	Sydney Children's Hospitals Network	Completed	No outcome recorded
Phase 3	NCT00856986	Mar 2009 → Apr 2010	type 2 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 3	NCT00789191	Nov 2008 → Aug 2009	type 2 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 3	NCT00623194	Feb 2008 → Sep 2009	type 1 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 3	NCT00656422	Nov 2007 → ?	obesity disorder, type 2 diabetes mellitus	University Hospital Tuebingen	Terminated	No outcome recorded
Phase 3	NCT00474045	May 2007 → Aug 2010	type 1 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 3	NCT00447382	Mar 2007 → Jul 2008	type 1 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 3	NCT00435019	Feb 2007 → Sep 2008	type 1 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 3	NCT00383877	Sep 2006 → Aug 2007	type 2 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 3	NCT01709929	Oct 2005 → Apr 2006	type 1 diabetes mellitus, type 2 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 3	NCT00504673	Apr 2005 → Dec 2006	type 2 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 3	NCT00106366	Mar → Dec 2005	type 2 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 3	NCT00104182	Feb 2005 → Feb 2006	type 2 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 3	NCT00184600	Nov 2004 → Aug 2009	type 2 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 3	NCT00097084	Sep 2004 → Dec 2005	type 2 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 3	NCT00095082	Sep 2004 → Dec 2005	type 1 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 3	NCT00184639	Aug 2004 → Nov 2005	type 1 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 3	NCT00184665	Jun 2004 → Sep 2006	type 1 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 3	NCT00605137	May 2004 → Apr 2005	type 1 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 3	NCT00592527	Apr → Dec 2004	type 2 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 3	NCT00595374	Dec 2003 → Oct 2004	type 1 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 3	NCT00605020	Dec 2003 → Mar 2005	type 2 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 3	NCT00604253	Dec 2003 → May 2005	type 2 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 3	NCT00604344	Apr 2003 → Mar 2005	type 1 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 3	NCT00283751	Mar 2003 → Nov 2004	type 2 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 3	NCT00604396	Mar 2003 → Jan 2004	type 2 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 3	NCT00312156	Aug 2002 → Aug 2003	type 1 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 3	NCT00312104	Apr 2002 → Mar 2003	type 1 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 3	NCT01486940	Mar → Oct 2002	type 1 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 3	NCT01697657	Sep 2001 → Nov 2002	type 1 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 3	NCT03220425	Feb → Nov 2001	type 1 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded

Phase 426 trials
Phase 4	NCT01868542	Jun 2013 → May 2015	type 2 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 4	NCT02048189	Mar 2012 → Feb 2015	—	Centre Hospitalier Universitaire Dijon	Terminated	No outcome recorded
Phase 4	NCT01889914	Jan 2012 → Mar 2015	type 2 diabetes mellitus	Centre Hospitalier Universitaire Dijon	Unknown	No outcome recorded
Phase 4	NCT01654120	Dec 2011 → Nov 2013	type 2 diabetes mellitus	Mountain Diabetes and Endocrine Center	Completed	No outcome recorded
Phase 4	NCT01486966	Nov 2011 → Jun 2012	type 2 diabetes mellitus	Novo Nordisk A/S	Terminated	No outcome recorded
Phase 4	NCT01828970	Jan 2010 → Sep 2012	diabetes mellitus	Centre Europeen d'Etude du Diabete	Completed	No outcome recorded
Phase 4	NCT00909480	May 2009 → Jun 2010	type 2 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 4	NCT00795600	Apr 2009 → Aug 2010	type 2 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 4	NCT00862875	Mar 2009 → Apr 2014	type 2 diabetes mellitus	Montreal Clinical Research Institute	Completed	No outcome recorded
Phase 4	NCT00699686	May 2008 → Mar 2010	cardiovascular disorder, type 2 diabetes mellitus	University of Padova	Completed	No outcome recorded
Phase 4	NCT00657943	Apr 2008 → Dec 2012	atherosclerosis, type 2 diabetes mellitus	Steno Diabetes Center Copenhagen	Completed	No outcome recorded
Phase 4	NCT00634842	Feb → Oct 2008	type 2 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 4	NCT00607737	Jan 2008 → Jun 2009	diabetes mellitus	Lise Tarnow	Completed	No outcome recorded
Phase 4	NCT00542399	Nov 2007 → Jan 2010	type 1 diabetes mellitus	Rabin Medical Center	Completed	No outcome recorded
Phase 4	NCT00564395	Aug 2007 → Dec 2009	type 1 diabetes mellitus	Montefiore Medical Center	Completed	No outcome recorded
Phase 4	NCT00506662	Jul 2007 → Dec 2008	type 2 diabetes mellitus	Novo Nordisk A/S	Terminated	No outcome recorded
Phase 4	NCT00509925	Jul 2007 → Jul 2008	type 1 diabetes mellitus	Novo Nordisk A/S	Terminated	No outcome recorded
Phase 4	NCT00346996	May 2007 → Nov 2011	type 1 diabetes mellitus	Lise Tarnow	Completed	No outcome recorded
Phase 4	NCT00521690	Dec 2006 → Aug 2007	type 2 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 4	NCT00590226	Dec 2006 → Jan 2008	type 2 diabetes mellitus	Emory University	Completed	No outcome recorded
Phase 4	NCT00313742	Apr → Nov 2006	type 1 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 4	NCT00490893	Mar → Dec 2006	diabetes mellitus, hypoglycemia	University Hospital Tuebingen	Terminated	No outcome recorded
Phase 4	NCT00264901	Oct 2005 → Nov 2006	type 2 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 4	NCT00274274	Sep 2005 → Nov 2006	type 2 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 4	NCT00135070	Jul 2005 → Jun 2006	type 2 diabetes mellitus	The Royal Bournemouth Hospital	Terminated	No outcome recorded
Phase 4	NCT00117780	Jun 2005 → Oct 2006	type 1 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded

Phase not applicable14 trials
—	NCT06419777	Sep 2024 → May 2026 overdue	gestational diabetes	Thomas Jefferson University	Recruiting	No outcome recorded
—	NCT03180281	Jul 2017 → Jan 2020	type 2 diabetes mellitus	First Affiliated Hospital Xi'an Jiaotong University	Unknown	No outcome recorded
—	NCT02204839	Jan 2014 → Jan 2015	type 1 diabetes mellitus	Northumbria University	Completed	No outcome recorded
—	NCT01974544	May 2013 → Dec 2015	type 2 diabetes mellitus	Pontificia Universidad Catolica de Chile	Unknown	No outcome recorded
—	NCT01837680	Mar 2013 → Mar 2015	gestational diabetes, type 2 diabetes mellitus	St. Luke's-Roosevelt Hospital Center	Completed	No outcome recorded
—	NCT01232946	Jan 2012 → Sep 2017	type 2 diabetes mellitus	Indiana University	Completed	No outcome recorded
—	NCT01377155	Jun → Dec 2011	type 2 diabetes mellitus	Diabetes Care Center	Completed	No outcome recorded
—	NCT01239550	Apr 2011 → Dec 2028 expected	diabetes mellitus, obesity disorder	Vanderbilt University	Active not recruiting	No outcome recorded
—	NCT00626080	Jan 2009 → Dec 2011	type 1 diabetes mellitus	Amsterdam UMC, location VUmc	Completed	No outcome recorded
—	NCT00659165	Apr 2008 → Dec 2010	diabetes mellitus	University of New Mexico	Completed	No outcome recorded
—	NCT00522210	Mar 2008 → Mar 2011	type 1 diabetes mellitus	University of Calgary	Completed	No outcome recorded
—	NCT00457093	Oct 2006 → May 2007	type 2 diabetes mellitus	Diabetes Care Center	Completed	No outcome recorded
—	NCT00564018	Sep 2006 → Feb 2009	type 1 diabetes mellitus	University of Texas Southwestern Medical Center	Terminated	No outcome recorded
—	NCT00467246	—	diabetes mellitus	The Royal Bournemouth Hospital	Withdrawn	No outcome recorded

Also used as a comparator or background therapy in 65 trials

Phase	Registry id	Dates	Indication	Sponsor	Status	Outcome
Phase 14 trials
Phase 1	NCT06685185 Comparator	Nov 2024 → Mar 2026	type 1 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 1	NCT01135927 Comparator	Jun → Oct 2010	type 1 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 1	NCT01043510 Comparator	Jan → Oct 2010	type 2 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 1	NCT00652288 Comparator	Apr 2007 → Sep 2011	type 1 diabetes mellitus	Yale University	Completed	No outcome recorded
Phase 21 trial
Phase 2	NCT00841087 Comparator	Jan → May 2009	type 1 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 317 trials
Phase 3	NCT04974528 Background	Sep 2021 → Oct 2024	type 1 diabetes mellitus, type 2 diabetes mellitus	Mannkind Corporation	Completed	No outcome recorded
Phase 3	NCT03377699 Comparator	Nov 2017 → Dec 2020	type 1 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 3	NCT02131272 Comparator	Jun 2014 → Jun 2016	type 2 diabetes mellitus	Novo Nordisk A/S	Terminated	No outcome recorded
Phase 3	NCT02033889 Background	Dec 2013 → Aug 2017	type 2 diabetes mellitus	Merck Sharp & Dohme LLC	Completed	No outcome recorded
Phase 3	NCT01835431 Comparator	Oct 2013 → Nov 2014	type 1 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 3	NCT01850615 Background	Sep 2013 → Nov 2014	type 2 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 3	NCT01831765 Background	Aug 2013 → May 2015	type 1 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 3	NCT01798706 Background	Jun 2013 → Feb 2015	type 2 diabetes mellitus	Sanofi	Completed	No outcome recorded
Phase 3	NCT01074268 Comparator	Feb → Dec 2010	type 1 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 3	NCT01003184 Comparator	Oct 2009 → Jul 2011	type 2 diabetes mellitus	AstraZeneca	Completed	No outcome recorded
Phase 3	NCT00978627 Comparator	Aug 2009 → May 2010	type 1 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 3	NCT00494013 Comparator	Aug 2007 → Sep 2008	type 2 diabetes mellitus	Eli Lilly and Company	Completed	No outcome recorded
Phase 3	NCT00487240 Comparator	Jun 2007 → Aug 2008	type 1 diabetes mellitus	Eli Lilly and Company	Completed	No outcome recorded
Phase 3	NCT00331604 Background	Aug 2006 → May 2008	type 2 diabetes mellitus	Novo Nordisk A/S	Terminated	No outcome recorded
Phase 3	NCT00322257 Background	May 2006 → Apr 2008	type 1 diabetes mellitus	Novo Nordisk A/S	Terminated	No outcome recorded
Phase 3	NCT00271284 Comparator	Oct 2005 → Sep 2008	type 1 diabetes mellitus	Sanofi	Completed	No outcome recorded
Phase 3	NCT00000620 Background	Sep 1999 → Jun 2009	atherosclerosis, coronary artery disorder, hyperlipoproteinemia, hypertensive disorder +1	National Heart, Lung, and Blood Institute (NHLBI)	Completed	No outcome recorded

Phase 433 trials
Phase 4	NCT07112339 Comparator	Aug 2025 → Aug 2026 overdue	type 2 diabetes mellitus	Novo Nordisk A/S	Recruiting	No outcome recorded
Phase 4	NCT04416269 Comparator	Aug 2020 → Mar 2026 overdue	diabetes mellitus	Emory University	Active not recruiting	No outcome recorded
Phase 4	NCT03620890 Comparator	Sep 2018 → Jul 2020	type 2 diabetes mellitus	The University of Texas Health Science Center, Houston	Completed	No outcome recorded
Phase 4	NCT02767596 Background	Jul 2016 → Feb 2017	type 2 diabetes mellitus	Laniado Hospital	Terminated	No outcome recorded
Phase 4	NCT02741687 Background	Jun 2016 → Apr 2017	hyperglycemia	Emory University	Completed	No outcome recorded
Phase 4	NCT02811484 Background	Jun 2016 → Jun 2018	type 2 diabetes mellitus	Weill Medical College of Cornell University	Withdrawn	No outcome recorded
Phase 4	NCT02967211 Comparator	Dec 2015 → Oct 2017	type 2 diabetes mellitus	Sanofi	Completed	No outcome recorded
Phase 4	NCT02967224 Comparator	Nov 2015 → Oct 2017	type 2 diabetes mellitus	Sanofi	Completed	No outcome recorded
Phase 4	NCT02451137 Comparator	Jun 2015 → Mar 2018	type 2 diabetes mellitus	Sanofi	Completed	No outcome recorded
Phase 4	NCT01966978 Comparator	Nov 2014 → Dec 2017	type 2 diabetes mellitus	University of Texas Southwestern Medical Center	Completed	No outcome recorded
Phase 4	NCT02219750 Comparator	Aug 2013 → Aug 2015	type 2 diabetes mellitus	Mackay Memorial Hospital	Completed	No outcome recorded
Phase 4	NCT01440439 Comparator	Nov 2011 → Jun 2012	type 1 diabetes mellitus	Buckinghamshire Healthcare NHS Trust	Unknown	No outcome recorded
Phase 4	NCT01354925 Comparator	Sep 2011	type 2 diabetes mellitus	Meir Medical Center	Completed	No outcome recorded
Phase 4	NCT01269034 Comparator	Dec 2010 → Jan 2017	type 1 diabetes mellitus	Albert Einstein College of Medicine	Completed	No outcome recorded
Phase 4	NCT01232491 Background	Oct 2010 → Nov 2011	type 2 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 4	NCT01165684 Background	Oct 2010 → Apr 2012	type 2 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 4	NCT01068652 Comparator	Mar 2010 → May 2012	type 2 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 4	NCT00906529 Comparator	May 2009 → Dec 2010	type 2 diabetes mellitus	University of Texas Southwestern Medical Center	Withdrawn	No outcome recorded
Phase 4	NCT00717288 Comparator	Jul 2008 → Mar 2010	diabetes mellitus	Ohio State University	Completed	No outcome recorded
Phase 4	NCT00742976 Comparator	Jun 2008 → Dec 2009	type 2 diabetes mellitus	Rigshospitalet, Denmark	Completed	No outcome recorded
Phase 4	NCT00591227 Comparator	May 2008 → Jul 2009	type 2 diabetes mellitus	Rush University Medical Center	Completed	No outcome recorded
Phase 4	NCT00941148 Comparator	Apr 2008 → Mar 2009	diabetes mellitus, noninsulin-dependent, 2	ikfe-CRO GmbH	Completed	No outcome recorded
Phase 4	NCT01076842 Comparator	Apr 2008 → Apr 2011	type 2 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 4	NCT00788840 Comparator	Jan 2008 → Aug 2009	obesity disorder, type 2 diabetes mellitus	University of Surrey	Completed	No outcome recorded
Phase 4	NCT00455858 Comparator	Nov 2007 → Oct 2008	type 2 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 4	NCT00537303 Background	Oct 2007 → Mar 2009	type 2 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 4	NCT00542620 Comparator	Sep 2007 → Mar 2009	type 1 diabetes mellitus	Novo Nordisk A/S	Completed	No outcome recorded
Phase 4	NCT00998335 Comparator	Jun 2007 → Feb 2010	type 2 diabetes mellitus	University of Florida	Completed	No outcome recorded
Phase 4	NCT00467649 Background	May 2007 → Apr 2008	type 2 diabetes mellitus	AstraZeneca	Completed	No outcome recorded
Phase 4	NCT00405418 Comparator	Nov 2006 → Jun 2008	type 2 diabetes mellitus	Sanofi	Completed	No outcome recorded
Phase 4	NCT01271517 Comparator	Sep 2005 → Mar 2011	type 1 diabetes mellitus	Karolinska Institutet	Unknown	No outcome recorded
Phase 4	NCT00566124 Comparator	Jan → May 2005	diabetes mellitus	University of Aarhus	Completed	No outcome recorded
Phase 4	NCT00747409 Comparator	Jul 2004 → Mar 2009	type 2 diabetes mellitus	Munich Municipal Hospital	Unknown	No outcome recorded

Phase not applicable10 trials
—	NCT06419803 Comparator	Sep 2024 → May 2026 overdue	gestational diabetes	Thomas Jefferson University	Recruiting	No outcome recorded
—	NCT04965051 Comparator	Aug 2021 → Dec 2023	type 1 diabetes mellitus	Second Affiliated Hospital, School of Medicine, Zhejiang University	Unknown	No outcome recorded
—	NCT03001323 Comparator	Jan 2017 → Jan 2019	diabetes mellitus	Hennepin Healthcare Research Institute	Terminated	No outcome recorded
—	NCT02846233 Comparator	Aug 2016 → Dec 2018	type 2 diabetes mellitus	University of California, San Francisco	Completed	No outcome recorded
—	NCT02824510 Comparator	Aug 2014 → Sep 2016	type 1 diabetes mellitus	Cliniques universitaires Saint-Luc- Université Catholique de Louvain	Completed	No outcome recorded
—	NCT02155023 Background	Jan 2014 → Jan 2015	diabetes mellitus	Medical University of Graz	Completed	No outcome recorded
—	NCT01310452 Comparator	Jan 2011 → ?	type 2 diabetes mellitus	Fudan University	Unknown	No outcome recorded
—	NCT01186003 Comparator	Aug 2010 → May 2014	diabetes mellitus	University of Colorado, Denver	Completed	No outcome recorded
—	NCT01420692 Comparator	Jun 2010 → Apr 2012	type 2 diabetes mellitus	Ankara University	Completed	No outcome recorded
—	NCT01022658 Comparator	Jan 2010 → Jul 2011	type 2 diabetes mellitus	Assistance Publique - Hôpitaux de Paris	Completed	No outcome recorded

Press releases naming this drug 2 releases

Date	Issuer	Release
2005-06-16	Novo Nordisk A/S	Novo Nordisk receives US approval of Levemir® and becomes the first company with a full range of insulin analogues in the US novonordisk.com ↗
2005-06-16	Novo Nordisk A/S	Novo Nordisk opnår FDA-godkendelse af Levemir® og kan dermed som de første tilbyde et fuldt sortiment af insulinanaloger i USA novonordisk.com ↗

Evidence & citations 19 cited values

Every value below carries the sentence it was read from. 181 sources stand behind the page.

Field	Value	Cited text
Known as	insulin detemir	“A Randomised, Open-labelled, Single-centre, Two-period Crossover Trial Investigating the Pharmacodynamics and Pharmacokinetics of Single s.c. Doses of NN304 (Insulin Detemir)...” NCT01542450 ↗ 120 “OBJECTIVE: We sought to determine if insulin detemir (IDet) is noninferior to insulin neutral protamine Hagedorn (NPH) for the treatment of gestational diabetes mellitus (GDM)...” PMID 26070699 ↗ Jun 2015 “Treatment with insulin detemir and aspart in patients with type 1 diabetes and recurrent severe hypoglycaemia resulted in a clinically significant reduced rate of severe...” PMID 24794703 ↗ May 2014 “The participants will either be prescribed weekly insulin icodec or a daily basal insulin (insulin glargine, insulin detemir or insulin degludec) based on current standards for...” NCT07112339 ↗ “We performed a non-inferiority trial comparing insulin detemir (Levemir) and biphasic insulin (NovoMix70) to standard care during Ramadan fast in insulin treated type 2...” PMID 26234442 ↗ Jul 2015 “Subjects will receive FIAsp combined with their pre-trial basal insulin (insulin human, insulin detemir or insulin glargine) treatment in combination with their pre-trial metformin.” NCT01850615 ↗ “AIMS: The efficacy of two basal insulins, insulin lispro protamine suspension (ILPS) and insulin detemir, was compared in basal-bolus regimens in Type 1 diabetes.” PMID 20536953 ↗ May 2010 “BACKGROUND: Insulin detemir, being used increasingly during pregnancy, may have pharmacologic benefits compared with neutral protamine Hagedorn.” PMID 33865836 ↗ Apr 2021 “This protocol addresses a comparison of insulin glargine and insulin detemir for patients evaluated by CGMS.” NCT00457093 ↗ “Individualized basal insulin (insulin degludec, insulin glargine or insulin detemir) for each patient.” NCT04974528 ↗ “During this arm/phase, patients take insulin Detemir subcutaneously for 3 months.” NCT00699686 ↗ “Insulin detemir was approved by the FDA for the treatment of diabetes in 2005.” NCT01239550 ↗ “AI (insulin detemir and insulin aspart, n = 61) and HI” PMID 26772807 ↗ Jan 2016 “Insulin detemir (Levemir® - Novolin® 4 pen)” NCT00862875 ↗ “Levemir (insulin detemir)” NCT00542399 ↗ “insulin detemir (Levemir)” NCT01076842 ↗ “insulin detemir (Levemir)” NCT00000620 ↗ “Insulin detemir” NCT02033889 ↗ NCT00312156 ↗ NCT01310452 ↗ NCT00435019 ↗ NCT01498926 ↗ NCT00604253 ↗ NCT00106366 ↗ NCT01547169 ↗ NCT00760448 ↗ NCT00271284 ↗ NCT01232491 ↗ NCT00604344 ↗ NCT01831765 ↗ NCT01497561 ↗ NCT01043510 ↗ NCT01486966 ↗ NCT01420692 ↗ NCT00607737 ↗ NCT01542450 ↗ NCT00474045 ↗ NCT02162407 ↗ NCT06685185 ↗ NCT00564018 ↗ NCT05124457 ↗ NCT01497574 ↗ NCT00604396 ↗ NCT00591227 ↗ NCT00504673 ↗ NCT00639626 ↗ NCT00537303 ↗ NCT01232946 ↗ NCT00795600 ↗ NCT05134987 ↗ NCT00455858 ↗ NCT01440439 ↗ NCT00841087 ↗ NCT00509925 ↗ NCT00873223 ↗ NCT00331604 ↗ NCT02741687 ↗ NCT00659165 ↗ NCT01003184 ↗ NCT00623194 ↗ NCT01497587 ↗ NCT00097084 ↗ NCT01497600 ↗ NCT01490099 ↗ NCT00566124 ↗ NCT00634842 ↗ NCT01835431 ↗ NCT01709929 ↗ NCT00542620 ↗ NCT01486940 ↗ NCT00447382 ↗ NCT00383877 ↗ NCT01868542 ↗ NCT03377699 ↗ NCT00742976 ↗ NCT00184600 ↗ NCT02131272 ↗ NCT00998335 ↗ NCT00605020 ↗ NCT00095082 ↗ NCT01135927 ↗ NCT00506662 ↗ NCT00117780 ↗ NCT02451137 ↗ NCT01165684 ↗ NCT01377155 ↗ NCT00467649 ↗ NCT01074268 ↗ NCT01513473 ↗ NCT00909480 ↗ NCT03220425 ↗ NCT00312104 ↗ NCT01595646 ↗ NCT02967211 ↗ NCT00283751 ↗ NCT04222348 ↗ NCT00322257 ↗ NCT00313742 ↗ NCT01100892 ↗ NCT00104182 ↗ NCT01697657 ↗ NCT00941148 ↗ NCT00564395 ↗ NCT00789191 ↗ NCT00626080 ↗ NCT00264901 ↗ NCT00605137 ↗ NCT02967224 ↗ NCT00595374 ↗ NCT00184665 ↗ NCT00978627 ↗ NCT00856986 ↗ NCT00657943 ↗ NCT00184639 ↗ NCT00405418 ↗ NCT00274274 ↗ NCT00592527 ↗ NCT01498939 ↗ NCT00521690 ↗ NCT01497535 ↗ NCT01068652 ↗
Known as	B29Lys(epsilon-tetradecanoyl),desB30 human insulin	“We compared the symptoms of hypoglycaemia induced by insulin detemir (NN304) (B29Lys(epsilon-tetradecanoyl),desB30 human insulin) and equally effective doses of neutral...” PMID 19707744 ↗ Aug 2009
Known as	B29Lys(ε-tetradecanoyl),desB30 human insulin	“insulin detemir (B29Lys(ε-tetradecanoyl),desB30 human insulin)” PMID 22002075 ↗ Oct 2011
Known as	detemir	“This 52-week multinational, randomised, open-label, parallel-group, non-inferiority trial compared clinical outcomes following supplementation of oral glucose-lowering drugs...” PMID 18204830 ↗ Jan 2008 34 “Discharge on 0.3 U/kg of admission long acting insulin glargine or detemir (provided by diabetes and endocrine clinic) regardless of participant's home insulin regimen at the...” NCT03001323 ↗ “Individually adjusted insulin detemir (Detemir) was given subcutaneoulsy (s.c.) at bedtime in the thigh at an initial dose of 0.1 U/kg once daily for 50 weeks in combination...” NCT01068652 ↗ “Used this way, the insulin analogue detemir has been associated with improved glycemic control of a magnitude similar to neutral protamine Hagedorn (NPH), with lower rates of...” PMID 17157113 ↗ Oct 2006 “To assess weight change when once-daily insulin detemir (detemir) or neutral protamine Hagedorn insulin (NPH) are used in already overweight Type 2 diabetes patients requiring...” PMID 18959604 ↗ Aug 2008 “Insulin detemir (detemir) has previously been shown to be associated with lower within-subject variability compared with other basal insulin preparations in adults with type 1...” PMID 18761644 ↗ Aug 2008 “AIMS: This study assessed the efficacy and safety of once-daily insulin initiation using insulin detemir (detemir) or insulin glargine (glargine) added to existing metformin in...” PMID 23421331 ↗ Mar 2013 “slow-acting insulin detemir mixed with aspart would have equivalent effects on blood glucose versus giving them as separate injections in children with type 1 diabetes.” NCT00564395 ↗ “Insulin glargine, neutral protamine hagedorn (NPH) insulin, detemir, lente and ultralente were considered as basal insulin.” NCT01798706 ↗ “insulin detemir (detemir) was noninferior to insulin glargine (glargine) as the basal insulin” PMID 19922879 ↗ Oct 2009 “basal-bolus therapy with insulin detemir (detemir), a new soluble basal insulin analogue” PMID 16842476 ↗ Jul 2006 “three randomly assigned insulin analog regimens (Detemir, Aspart, and their combination)” PMID 28954218 ↗ Sep 2017 “Basal insulin with glargine or detemir will be used as per the hospital formulary.” NCT04416269 ↗ “Patients were randomized 2 : 1 to detemir (n = 331) or NPH (n = 166) groups.” PMID 18387078 ↗ Apr 2008 “long acting insulin analogues such as detemir o glargine will be added.” NCT01974544 ↗ “(Glargine, Lantus, Sanofi-Aventis, or Detemir, Levemir, Novo Nordisk)” NCT02204839 ↗ “Daily bedtime subcutaneous insulin Detemir in individualized doses.” NCT00699686 ↗ “Subcutaneous insulin (aspart, glargine, detemir)” NCT00764556 ↗ “Insulin Glargine or detemir 0.2U/kg qd” NCT03180281 ↗ “Glargine, Detemir, Degludec” NCT02767596 ↗ “insulin detemir (detemir)” PMID 36623517 ↗ Jan 2023 NCT00522210 ↗ NCT02824510 ↗ NCT00494013 ↗ NCT01461616 ↗ NCT00135070 ↗ NCT00590226 ↗ NCT00652288 ↗ NCT01271517 ↗ NCT01966978 ↗ NCT00717288 ↗ NCT01828970 ↗ NCT00490893 ↗ NCT00788840 ↗ NCT01186003 ↗
Known as	IDet	“The aim of this trial was to evaluate the efficacy and safety of the combination of once-daily insulin detemir (IDet) and sitagliptin (SITA) versus SITA ± sulphonylurea (SU),...” PMID 21205123 ↗ Mar 2011 9 “OBJECTIVE: This randomized, controlled noninferiority trial aimed to compare the efficacy and safety of insulin detemir (IDet) versus neutral protamine Hagedorn (NPH) (both...” PMID 22851598 ↗ Jul 2012 “Patients were randomized 1:1 (age stratified: 1-<6 years; 6-<12 years; 12-<18 years) to IDegAsp once daily (OD) plus insulin aspart (IAsp) for remaining meals (IDegAsp + IAsp),...” PMID 30014589 ↗ Aug 2018 “This randomised (1:1), multinational, open-labelled, parallel group trial compared insulin detemir (IDet) with neutral protamine Hagedorn (NPH) insulin, in combination with...” PMID 21418455 ↗ Mar 2011 “OBJECTIVE: We sought to determine if insulin detemir (IDet) is noninferior to insulin neutral protamine Hagedorn (NPH) for the treatment of gestational diabetes mellitus (GDM)...” PMID 26070699 ↗ Jun 2015 “To evaluate efficacy and tolerability of a co-formulation of insulin degludec and insulin aspart (IDegAsp) with insulin aspart (IAsp) at other meals compared with basal-bolus...” PMID 22933438 ↗ Aug 2012 “The efficacy and safety of insulin degludec (IDeg) was compared with insulin detemir (IDet), both administered once daily (OD) as basal treatment in participants with type 1...” PMID 24702700 ↗ May 2014 “This treat-to-target study compared the efficacy and safety of insulin detemir (IDet) and insulin glargine (IGla) in a basal-bolus (insulin aspart) regimen in type 2 diabetes.” PMID 19565569 ↗ Sep 2009 “Insulin degludec (IDeg) once-daily was compared with insulin detemir (IDet) once- or twice-daily” PMID 25683037 ↗ Feb 2015 “the long-acting insulin analogues insulin detemir (IDet) and NPH insulin (NPH)” PMID 16918592 ↗ Sep 2006
Known as	Ins levemir	ChEMBL registry synonym — accepted as the source's own label CHEMBL2104391 ↗
Known as	Insulin detemir recombinant	ChEMBL registry synonym — accepted as the source's own label CHEMBL2104391 ↗
Known as	insulin Detemir: Levemir	“insulin detemir (Levemir)” NCT00000620 ↗ 1 “insulin Detemir: Levemir” NCT01461616 ↗
Known as	Insulin Levemir	“Patient specific dose insulin Levemir (detemir) twice daily (BID) subcutaneous (SC) injection x 32 weeks” NCT00487240 ↗ 1 NCT00656422 ↗
Known as	Insulin,detemir,human	ChEMBL registry synonym — accepted as the source's own label CHEMBL2104391 ↗
Known as	Insulina detemir	ChEMBL registry synonym — accepted as the source's own label CHEMBL2104391 ↗
Known as	Insuline detemir	ChEMBL registry synonym — accepted as the source's own label CHEMBL2104391 ↗
Known as	Levemir	“We performed a non-inferiority trial comparing insulin detemir (Levemir) and biphasic insulin (NovoMix70) to standard care during Ramadan fast in insulin treated type 2...” PMID 26234442 ↗ Jul 2015 22 “Insulin detemir (Levemir®) 100 U/mL, was injected subcutaneously once daily with the evening meal or at bedtime as add-on to subject's pre-trial treatment of metformin for 26 weeks.” NCT01232491 ↗ “the patient will receive an additional injection of basal insulin LEVEMIR® : five injections per day” NCT01889914 ↗ “Participants will get insulin NNC0363-0845 as well as insulin detemir (Levemir®).” NCT05134987 ↗ “basal insulin (Lantus® [insulin glargine], or Levemir® [insulin detemir])” NCT00467649 ↗ “(Glargine, Lantus, Sanofi-Aventis, or Detemir, Levemir, Novo Nordisk)” NCT02204839 ↗ “Levemir/Lantus/Tresiba plus NovoLog/Humalog/Apidra” NCT04965051 ↗ “Levemir, durg class: long-acting insulin” NCT02219750 ↗ “Lantus, Levemir, Novolog, Lispro” NCT02811484 ↗ “Lantus, Toujeo, NPH, levemir” NCT02846233 ↗ “Levemir® (insulin detemir)” NCT01868542 ↗ “Lantus/ Levemir” NCT01269034 ↗ “Levemir” NCT00639626 ↗ “Levemir” NCT06419803 ↗ “Levemir” NCT06419777 ↗ “Levemir” NCT02155023 ↗ “Levemir” NCT01654120 ↗ NCT00906529 ↗ NCT00542399 ↗ NCT02048189 ↗ NCT02496780 ↗ NCT00810589 ↗ NCT00467246 ↗
Known as	levemir insulin	“Drug: levemir insulin” NCT02496780 ↗
Known as	NN304	“A Randomised, Open-labelled, Single-centre, Two-period Crossover Trial Investigating the Pharmacodynamics and Pharmacokinetics of Single s.c. Doses of NN304 (Insulin Detemir)...” NCT01542450 ↗ 2 “A 48-week, Randomised, Multi-centre, Openlabelled, Parallel-group Trial to Compare the Efficacy and the Safety of NN304 (Insulin Detemir) and NPH Human Insulin in Subjects With...” NCT00604344 ↗ “We compared the symptoms of hypoglycaemia induced by insulin detemir (NN304) (B29Lys(epsilon-tetradecanoyl),desB30 human insulin) and equally effective doses of neutral...” PMID 19707744 ↗ Aug 2009
Action	Activate	“enhanced signaling through the insulin receptor” NCT01239550 ↗ 1 “Insulin receptor agonist” CHEMBL2104391 ↗
Modality	Protein / enzyme biologic	“subcutaneous insulin analogues” NCT00135070 ↗
Route	Subcutaneous	“evening SC injection of detemir” PMID 17157113 ↗ Oct 2006
Target	INSR	“Insulin receptor agonist” CHEMBL2104391 ↗