Effect of Detemir and Sitagliptin on Blood Glucose Control in Type 2 Diabetes

Summary

This trial is conducted in Asia, Europe and North America. This trial aims for comparison of the effect on the glycemic control in subjects with type 2 diabetes of basal insulin analogue with one oral anti-diabetic drug (OAD) versus oral anti-diabetic drug alone.

Timeline

Start

2008-11

Primary completion

2009-08

Completion

2009-08

Outcome

Met primary endpoint

registry analysis (superiority or other test); Comb vs Sita; p = 0.0010; Mean Difference (Final Values) -0.55 (95% CI -0.77 to -0.33) NCT00789191 ↗

paper Significantly higher reductions in HbA1c, FPG and SMPG were achieved with IDet + SITA + MET compared with SITA + MET ± SU. PMID 21205123 ↗

Publications

• Results Hollander P, Raslova K, Skjoth TV, Rastam J, Liutkus JF. Efficacy and safety of insulin detemir once daily in combination with sitagliptin and metformin: the TRANSITION randomized controlled trial. Diabetes Obes Metab. 2011 Mar;13(3):268-75. doi: 10.1111/j.1463-1326.2010.01351.x.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	insulin detemir	Protein / enzyme biologic	—	Subcutaneous
Background	Metformin	Small molecule	1000 mg	—
Background	Sitagliptin	Small molecule	100 mg	—

Indications