Effect of Detemir and Sitagliptin on Blood Glucose Control in Type 2 Diabetes

Phase 3 Completed 222 enrolled Novo Nordisk A/S

RandomizedParallel-groupOpen-labelTreatment

Summary

This trial is conducted in Asia, Europe and North America. This trial aims for comparison of the effect on the glycemic control in subjects with type 2 diabetes of basal insulin analogue with one oral anti-diabetic drug (OAD) versus oral anti-diabetic drug alone.

Timeline

Start: 2008-11
Primary completion: 2009-08
Completion: 2009-08

Publications

Results Hollander P, Raslova K, Skjoth TV, Rastam J, Liutkus JF. Efficacy and safety of insulin detemir once daily in combination with sitagliptin and metformin: the TRANSITION randomized controlled trial. Diabetes Obes Metab. 2011 Mar;13(3):268-75. doi: 10.1111/j.1463-1326.2010.01351.x.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	insulin detemir	Protein / enzyme biologic	—	Subcutaneous
Background	Metformin	Small molecule	1000 mg	—
Background	Sitagliptin	Small molecule	100 mg	—

Effect of Detemir and Sitagliptin on Blood Glucose Control in Type 2 Diabetes

Summary

Timeline

Publications

Drugs

Indications