drugset / Trial / NCT00742066
Role of AT1-receptor Blockers in Insulin-induced Vasodilation.
RandomizedCrossoverDouble-blindBasic science
Summary
In this study we hypothesize that blocking the angiotensin II AT1-receptor improves the insulin-induced microvascular dilatation. Objectives: 1. Does blockade of the angiotensin II AT1-receptor improve the insulin-induced microvascular effects in hypertensive patients. 2. Does blockade of the angiotensin II AT1-receptor impair the insulin-induced microvascular effects in normotensive control subjects?
Timeline
- Start
- 2008-03
- Primary completion
- 2009-07
- Completion
- 2009-07
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Felodipine | Small molecule | 10 mg | — |
| Subject | Irbesartan | Small molecule | 600 mg | Oral |