drugset / Trial / NCT02653872
A Phase I Study to Assess PK of AZD7986 Alone & With Verapamil, Itraconazole or Diltiazem in Healthy Subjects
Non-randomizedParallel-groupOpen-labelBasic science
Summary
This is a phase 1, non-randomized, fixed sequence, 3-period, drug-drug interaction study to assess the pharmacokinetics (PK) of AZD7986 in healthy subjects when administered alone and in combination with multiple doses of verapamil and itraconazole or diltiazem
Timeline
- Start
- 2016-01-22
- Primary completion
- 2016-04-13
- Completion
- 2016-04-13
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Brensocatib | Small molecule | 25 mg | Oral |
| Comparator | Diltiazem | Small molecule | 360 mg | — |
| Comparator | Itraconazole | Small molecule | 200 mg | Oral |
| Comparator | Verapamil | Other / unclassified | 240 mg | Oral |
Indications
No indication recorded.