Drugs / Brensocatib
last change Jun 2026 re-read 1 minute ago

Brensocatib

also known as AZD7986 · INS1007

Small molecule targets CTSC via inhibition

Developed for
bronchiectasis · chronic rhinosinusitis · COVID-19 · cystic fibrosis · hidradenitis suppurativa
Investigated by
Insmed Incorporated · AstraZeneca · NHS Tayside · University of Dundee

Regulatory milestones approvals, filings & regulatory actions · 2 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Approved EU (EMA) Brinsupri 2025-11-18 europa.eu
Approved US (FDA) BRINSUPRI 2025-08-12 fda.gov

Trials 18 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 111 trials
Phase 1 NCT06344728 Apr → May 2024 Insmed Incorporated Completed No outcome recorded
Phase 1 NCT06178783 Dec 2023 → Jan 2024 Insmed Incorporated Completed No outcome recorded
Phase 1 NCT05965570 Jul → Sep 2023 Insmed Incorporated Completed No outcome recorded
Phase 1 NCT05826574 May → Jul 2023 Insmed Incorporated Completed No outcome recorded
Phase 1 NCT05517525 Oct 2022 → Jun 2023 Insmed Incorporated Completed No outcome recorded
Phase 1 NCT05355935 Apr → Oct 2022 Insmed Incorporated Completed No outcome recorded
Phase 1 NCT05652257 Aug → Sep 2021 Insmed Incorporated Completed No outcome recorded
Phase 1 NCT05673603 Jul 2021 → Feb 2023 impaired renal function disease Insmed Incorporated Completed No outcome recorded
Phase 1 NCT05927597 Jan → Aug 2019 Insmed Incorporated Completed No outcome recorded
Phase 1 NCT02653872 Jan → Apr 2016 AstraZeneca Completed No outcome recorded
Phase 24 trials
Phase 2 NCT06685835 Dec 2024 → Feb 2026 hidradenitis suppurativa Insmed Incorporated Terminated No outcome recorded
Phase 2 NCT06013241 Oct 2023 → Sep 2025 chronic rhinosinusitis Insmed Incorporated Completed No outcome recorded
Phase 2 NCT05090904 Nov 2021 → Nov 2022 cystic fibrosis Insmed Incorporated Completed No outcome recorded
Phase 2 NCT03218917 Oct 2017 → Dec 2019 bronchiectasis Insmed Incorporated Completed No outcome recorded
Phase 32 trials
Phase 3 NCT04594369 Dec 2020 → Oct 2024 bronchiectasis Insmed Incorporated Completed No outcome recorded
Phase 3 NCT04817332 Jun 2020 → Feb 2021 COVID-19 University of Dundee Completed No outcome recorded
Phase not stated1 trial
NCT05344508 bronchiectasis Insmed Incorporated Approved for marketing No outcome recorded

Evidence & citations 7 cited values

Every value below carries the sentence it was read from. 21 sources stand behind the page.

FieldValueCited text
Known as Brensocatib ClinicalTrials.gov intervention name — accepted as the source's own label NCT06178783
14

NCT03218917

NCT05652257

NCT05344508

NCT06013241

NCT05673603

NCT05355935

NCT05965570

NCT05517525

NCT04817332

NCT06685835

NCT06344728

NCT04594369

NCT05090904

NCT05826574

Known as AZD7986 “Brensocatib (INS1007, formerly AZD7986) is an orally delivered selective, competitive, and reversible inhibitor of DPP1.” NCT04817332
2

NCT02303574

NCT02653872

Known as INS1007 “Brensocatib (INS1007) is an oral reversible inhibitor of dipeptidyl peptidase 1 (DPP-1), an enzyme responsible for the activation of neutrophil serine proteases.” PMID 32897034 Sep 2020
1

NCT05927597

Action Inhibit “reversible inhibitor of dipeptidyl peptidase 1 (DPP-1)” PMID 37198686 May 2023
Modality Small molecule CHEMBL3900409
Route Oral “single and multiple oral doses of AZD7986 in healthy volunteers” NCT02303574
Target DPP1 “inhibitor of dipeptidyl peptidase 1 (DPP-1)” PMID 37198686 May 2023