drugset / Trial / NCT02750319
Amiodarone and N-Acetylcysteine or Amiodarone Alone for Preventing Atrial Fibrillation After Thoracic Surgery
Phase 3
Active not recruiting
184 enrolled
Memorial Sloan Kettering Cancer Center
The Cleveland Clinic · collabVanderbilt University School of Medicine · collabWashington University School of Medicine · collab
RandomizedParallel-groupDouble-blindTreatment
Summary
This trial will be comparing the combination of amiodarone and NAC (n=122) to amiodarone alone and NAC matched placebo (n=122) to determine the rates with which sustained (lasting \>30 seconds) or clinically significant POAF is reduced in high risk patients within 7 days after major thoracic surgery.
Timeline
- Start
- 2016-04
- Primary completion
- 2027-04
- Completion
- 2027-04
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | N-acetylcysteine | Small molecule | 50 mg/kg | Intravenous |
| Background | Amiodarone | Small molecule | 1 g | Intravenous |
Indications
No indication recorded.