N-acetylcysteine

also known as NAC · N-Acetyl-L-Cysteine · Mucomyst · acetylcysteine · N-AcetylCystein · ACC · ACC long · ACC-600 · +14 more

Small molecule targets MTOR, VWF via inhibition

Developed for: COVID-19 · acute kidney injury · chronic kidney disease · alcohol-related disorders · drug-induced liver injury · cocaine dependence · Parkinson disease · alcohol dependence
+219 more
· alcoholic hepatitis · autism spectrum disorder · nicotine dependence · schizophrenia · traumatic brain injury · tuberculosis · cannabis dependence · disorder of defective peroxisome oxidative status · end stage renal failure · idiopathic pulmonary fibrosis · mucositis · obsessive-compulsive disorder · poisoning · polycystic ovary syndrome · post-traumatic stress disorder · acute tubulointerstitial nephritis · autism · bipolar disorder · chronic obstructive pulmonary disease · chronic renal failure syndrome · depressive disorder · diabetic kidney disease · impaired renal function disease · proteinuria · pulmonary tuberculosis · retinitis pigmentosa · ST-elevation myocardial infarction · type 2 diabetes mellitus · acute liver failure · acute respiratory distress syndrome · anosmia · asthma · biliary atresia · carpal tunnel syndrome · chorioamnionitis · chronic apical periodontitis · coronary artery disorder · diabetes mellitus · drug-induced hearing loss · female infertility · hepatitis · infectious disease with sepsis · irritable bowel syndrome · ischemic disease · kidney failure · major depressive disorder · methamphetamine dependence · mucus inspissation of respiratory tract · NAFLD1 · neurofibromatosis type 1 · pathological gambling · platinum-induced ototoxicity · psychotic disorder · respiratory system disorder · schizoaffective disorder · schizophreniform disorder · sickle cell disease · substance dependence · substance-related disorder · thrombotic microangiopathy · tinnitus · ulcer of lower limbs · ulcerative colitis · acquired polycythemia vera · acute apical periodontitis · acute bronchiolitis · acute kidney tubular necrosis · acute lung injury · adrenomyeloneuropathy · alcohol abuse · Alzheimer disease · atopic eczema · bacterial vaginosis · bipolar I disorder · bipolar II disorder · borderline personality disorder · brain hypoxia - ischemia · brain injury · breast cancer · breast carcinoma · breasts and/or nipples, aplasia or hypoplasia of, 1 · bulimia nervosa · carbon monoxide-induced delayed encephalopathy · chemotherapy-induced neuropathy · chemotherapy-induced oral mucositis · childhood acute lymphoblastic leukemia · chronic bronchitis · chronic pain syndrome · chronic thromboembolic pulmonary hypertension · cirrhosis of liver · cisplatin toxicity · classic homocystinuria · cognitive disorder · common cold · congenital heart disease · congestive heart failure · connective tissue disorder · Cornelia de Lange syndrome · de Quervain disease · dengue disease · dental pulp disorder · diabetic embryopathy · diabetic retinopathy · discharging ear · disease of the tendon · disease related to solid organ transplantation · DNA repair disease · dry age related macular degeneration · eating disorder · epilepsy · essential thrombocythemia · fatty liver disease · functional diarrhea · Gaucher disease · Gaucher disease type I · hearing loss disorder · hearing loss, noise-induced, susceptibility to · Helicobacter pylori infectious disease · hepatic veno-occlusive disease · hepatitis C virus infection · hepatocellular carcinoma · homocystinuria · hyperpigmentation of the skin · hypertrophic cardiomyopathy · hypotensive disorder · impulse control disorder · infectious disease · inherited glutathione metabolism disease · interstitial lung disease · ischemic stroke · isoniazid toxicity · kidney disorder · leptospirosis · liver disorder · liver failure · lymphoma · male infertility · migraine disorder · mitochondrial disease · mood disorder · Morton neuroma · myelofibrosis · nephropathic cystinosis · Niemann-Pick disease type C · non-verbal learning disability · obstructive jaundice · obstructive sleep apnea syndrome · opiate dependence · otitis media · ovarian endometriosis · palmar fibromatosis · peroneal neuropathy · plantar fasciitis · pneumonia · preterm premature rupture of the membranes · primary thrombocytopenia · pseudomyxoma peritonei · pulmonary fibrosis · pulmonary sarcoidosis · rotator cuff syndrome · SELENON-related myopathy · sleep apnea syndrome · stereotypic movement disorder · susceptibility to familial cutaneous melanoma · systemic sclerosis · tarsal tunnel syndrome · thrombotic disease · thrombotic thrombocytopenic purpura · Tourette syndrome · transposition of the great arteries · trichotillomania · uterine corpus leiomyoma · viral pneumonia · visceral leishmaniasis · acquired aneurysmal subarachnoid hemorrhage · androgenetic alopecia · atherosclerosis · beta thalassemia · beta-thalassemia major · bronchiectasis · cervical incompetence · chronic mountain sickness · cognitive impairment with or without cerebellar ataxia · cystic fibrosis · diabetic macular edema · disruptive behavior disorder · euthyroid sick syndrome · fibromyalgia · Fuchs' endothelial dystrophy · infectious peritonitis · infertility disorder · influenza · intracranial vasospasm · limb ischemia · lung disorder · multiple sclerosis · myalgic encephalomeyelitis/chronic fatigue syndrome · myopathy · nail disorder · necrotizing enterocolitis · neonatal sepsis · neuromuscular disease · neurotic excoriation · noise induced hearing loss · organophosphate poisoning · pancreatitis · peripheral arterial disease · persian gulf syndrome · prediabetes syndrome · primary progressive multiple sclerosis · psychiatric disorder · relapsing-remitting multiple sclerosis · secondary progressive multiple sclerosis · severe acute respiratory syndrome · Sjogren syndrome · substance abuse · systemic lupus erythematosus · thrombocytopenia · wet macular degeneration
Investigated by: Medical University of South Carolina · National Institute on Drug Abuse (NIDA) · University of Minnesota · Yale University · Ain Shams University · National Institute of Neurological Disorders and Stroke (NINDS)
+373 more
· National Institutes of Health (NIH) · Assaf-Harofeh Medical Center · Cairo University · Stanford University · University of Washington · Zambon SpA · Assiut University · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) · Institute of Liver and Biliary Sciences, India · Johns Hopkins University · Massachusetts General Hospital · National Institute on Alcohol Abuse and Alcoholism (NIAAA) · United States Department of Defense · University of Michigan · Ludwig-Maximilians - University of Munich · Mahidol University · Memorial Sloan Kettering Cancer Center · National Heart, Lung, and Blood Institute (NHLBI) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · National Taiwan University Hospital · ScandiBio Therapeutics AB · São Paulo Research Foundation · The Aurum Institute NPC · The First Affiliated Hospital of Soochow University · University of California, Irvine · University of California, San Francisco · University of Miami · University of Oxford · Altheus Therapeutics, Inc. · American Academy of Child Adolescent Psychiatry. · Asian Institute of Gastroenterology, India · Baylor College of Medicine · Bloodworks · Centre Hospitalier Universitaire Saint Pierre · Centre Hospitalier Universitaire, Amiens · Children's Hospital Medical Center, Cincinnati · Duke University · Emory University · Ewha Womans University · Far Eastern Memorial Hospital · Hospital de Clinicas de Porto Alegre · Imperial College London · Indiana University · Institute for Translational Neuroscience · Instituto Nacional de Cardiologia Ignacio Chavez · Istanbul Medipol University Hospital · KTH Royal Institute of Technology · Lindner Center of HOPE · Mansoura University · MonitorCRO · National Center for Advancing Translational Sciences (NCATS) · National Human Genome Research Institute (NHGRI) · National Institute for Medical Research, Tanzania · Radboud University Medical Center · Rare Diseases Clinical Research Network · Royan Institute · Sahlgrenska University Hospital · Siriraj Hospital · Suleyman Demirel University · TC Erciyes University · Tanta University · Tehran University of Medical Sciences · The Physicians' Services Incorporated Foundation · US Department of Veterans Affairs · University Hospital Bispebjerg and Frederiksberg · University of California, Los Angeles · University of Chicago · University of Cincinnati · University of Maryland, Baltimore · University of Sao Paulo · University of Sydney · University of Utah · VA Office of Research and Development · Washington University School of Medicine · all 379 on the full record

Trials 312 · started per year

today

1998199920002001200220032004200520062007200820092010201120122013201420152016201720182019202020212022202320242025202620272028

Phase	Registry id	Dates	Indication	Sponsor	Status	Outcome
Phase 021 trials · 1 met primary · 1 missed
Phase 0	NCT07323446	Jan 2027 → Jan 2030 expected	—	Massachusetts General Hospital	Not yet recruiting	No outcome recorded
Phase 0	NCT05371288	Jun → Sep 2025	COVID-19	University of California, Irvine	Withdrawn	No outcome recorded
Phase 0	NCT05666089	Feb 2023 → Feb 2024	—	Cairo University	Unknown	No outcome recorded
Phase 0	NCT05610072	Dec 2022 → Mar 2026	substance-related disorder	William Stoops	Completed	No outcome recorded
Phase 0	NCT05287724	Jun 2022 → Jan 2024	skin disorder	Wright State University	Completed	No outcome recorded
Phase 0	NCT04632069	Aug 2021 → Mar 2024	diabetic embryopathy, eating disorder	Medical University of South Carolina	Completed	Met primary
Phase 0	NCT03730064	Nov 2018 → Mar 2021	bipolar disorder, depressive disorder	Martin Lan	Completed	No outcome recorded
Phase 0	NCT03056014	Nov 2018 → Mar 2020	—	University of Maryland, Baltimore	Terminated	No outcome recorded
Phase 0	NCT05551624	Jul 2018 → Dec 2019	primary thrombocytopenia	Hospital Civil de Guadalajara	Completed	No outcome recorded
Phase 0	NCT03451435	Jun 2018 → Apr 2019	dental pulp disorder	University of California, Los Angeles	Terminated	No outcome recorded Stop: Enrollment
Phase 0	NCT03346681	Feb 2018 → Jan 2021	acute respiratory distress syndrome	Prisma Health-Midlands	Withdrawn	No outcome recorded Stop: Enrollment
Phase 0	NCT03216954	Sep 2017 → Apr 2020	alcohol-related disorders	William Stoops	Completed	No outcome recorded
Phase 0	NCT03120468	May 2017 → Jun 2019	alcohol dependence	Nassima Ait-Daoud Tiouririne	Completed	No outcome recorded
Phase 0	NCT04643821	Jan 2015 → Apr 2017	brain hypoxia - ischemia	Medical University of South Carolina	Completed	No outcome recorded
Phase 0	NCT02269540	Oct 2014 → Jun 2018	major depressive disorder	Centre for Addiction and Mental Health	Completed	No outcome recorded
Phase 0	NCT02481609	Jul 2014 → Dec 2017	anosmia	University of Miami	Completed	No outcome recorded
Phase 0	NCT02335060	May → Sep 2014	—	Yale University	Terminated	No outcome recorded
Phase 0	NCT02141620	May 2014 → Apr 2016	cocaine abuse, cocaine dependence	University of Kentucky	Completed	No outcome recorded
Phase 0	NCT01808521	May 2013 → Jul 2017	thrombotic thrombocytopenic purpura	Bloodworks	Completed	No outcome recorded
Phase 0	NCT01905696	Mar → Aug 2013	—	Duke University	Terminated	No outcome recorded Stop: Business
Phase 0	NCT01017796	Jan 2009 → Jan 2010	acute tubulointerstitial nephritis	University of Thessaly	Unknown	Missed primary

Phase 125 trials
Phase 1	NCT06260566	Oct 2026 → Oct 2030 expected	biliary atresia	Sanjiv Harpavat	Not yet recruiting	No outcome recorded
Phase 1	NCT07058090	Jul → Dec 2025 overdue	drug-induced liver injury, tuberculosis	Liaquat National Hospital & Medical College	Not yet recruiting	No outcome recorded
Phase 1	NCT05241262	Jul 2023 → Mar 2026 overdue	mitochondrial disease	Michio Hirano, MD	Recruiting	No outcome recorded
Phase 1	NCT05215743	Aug → Nov 2022	acute myocardial infarction, ischemic disease	University of Chile	Completed	No outcome recorded
Phase 1	NCT05081479	Dec 2021 → Oct 2026 expected	lymphoma	Memorial Sloan Kettering Cancer Center	Active not recruiting	No outcome recorded
Phase 1	NCT04982146	Sep 2021 → May 2022	pseudomyxoma peritonei	Maimónides Biomedical Research Institute of Córdoba	Unknown	No outcome recorded
Phase 1	NCT04900129	Dec 2020	COVID-19	Sher-E-Bangla Medical College	Completed	No outcome recorded
Phase 1	NCT04545008	Oct 2020 → Jun 2021	COVID-19	Prisma Health-Upstate	Terminated	No outcome recorded Stop: Enrollment
Phase 1	NCT04370288	Apr → Sep 2020	COVID-19	Mashhad University of Medical Sciences	Unknown	No outcome recorded
Phase 1	NCT03881163	Nov 2019 → Jan 2020	respiratory system disorder	Zambon SpA	Completed	No outcome recorded
Phase 1	NCT03999021	Jun 2019 → Aug 2026 overdue	retinitis pigmentosa	Johns Hopkins University	Active not recruiting	No outcome recorded
Phase 1	NCT03104725	Sep 2017 → Feb 2020	Parkinson disease	National Institute of Neurological Disorders and Stroke (NINDS)	Terminated	No outcome recorded Stop: Enrollment
Phase 1	NCT03063021	Feb 2017 → Feb 2019	retinitis pigmentosa	Johns Hopkins University	Completed	No outcome recorded
Phase 1	NCT02094625	Mar 2016 → Sep 2020	childhood malignant neoplasm, liver and intrahepatic bile duct neoplasm, osteosarcoma, primitive neuroectodermal tumor	Children's Hospital Los Angeles	Completed	No outcome recorded
Phase 1	NCT03679442	Sep 2014 → Jun 2015	drug-induced liver injury	University of Aarhus	Completed	No outcome recorded
Phase 1	NCT02206178	Sep 2013 → Jan 2014	—	University Hospital, Clermont-Ferrand	Completed	No outcome recorded
Phase 1	NCT01878695	Jul 2012 → May 2015	breast carcinoma	Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University	Completed	No outcome recorded
Phase 1	NCT01537926	Jan 2012 → Dec 2016	hypertrophic cardiomyopathy	The University of Texas Health Science Center, Houston	Completed	No outcome recorded
Phase 1	NCT01427517	Jul 2011 → Dec 2012	Gaucher disease, Parkinson disease	University of Minnesota	Completed	No outcome recorded
Phase 1	NCT01251029	Jan 2011 → Sep 2013	chronic kidney disease	Assaf-Harofeh Medical Center	Unknown	No outcome recorded
Phase 1	NCT01138137	Jun 2010 → Dec 2014	ovarian carcinoma, primary peritoneal carcinoma	OHSU Knight Cancer Institute	Withdrawn	No outcome recorded Stop: Business
Phase 1	NCT01020708	Nov 2009 → Sep 2010	ulcerative colitis	Altheus Therapeutics, Inc.	Completed	No outcome recorded
Phase 1	NCT00575419	Nov 2007 → Sep 2014	acute tubulointerstitial nephritis	Oregon Health and Science University	Terminated	No outcome recorded Stop: Enrollment
Phase 1	NCT00273702	Jan → Sep 2006	pathological gambling	University of Minnesota	Completed	No outcome recorded
Phase 1	NCT00136825	Mar 2003 → Sep 2005	cocaine dependence	National Institute on Drug Abuse (NIDA)	Completed	No outcome recorded

Phase 1/218 trials · 2 missed
Phase 1/2	NCT04520139	May → Dec 2026 expected	cognitive disorder, ovarian cancer	University of California, Irvine	Recruiting	No outcome recorded
Phase 1/2	NCT04015557	Feb → Jun 2022	classic homocystinuria	Hospital de Clinicas de Porto Alegre	Suspended	No outcome recorded
Phase 1/2	NCT05123365	Jan 2022 → Nov 2026 expected	acquired polycythemia vera, essential thrombocythemia, myelofibrosis	University of California, Irvine	Recruiting	No outcome recorded
Phase 1/2	NCT03720483	Jan 2022 → Dec 2023	idiopathic pulmonary fibrosis	University of Colorado, Denver	Withdrawn	No outcome recorded
Phase 1/2	NCT05658549	May → Jul 2021	COVID-19	Universitas Sebelas Maret	Completed	No outcome recorded
Phase 1/2	NCT04557215	Nov 2020 → Aug 2021	irritable bowel syndrome	Cedars-Sinai Medical Center	Completed	No outcome recorded
Phase 1/2	NCT04013555	Jan 2020 → Aug 2024	schizoaffective disorder, schizophrenia, schizophreniform disorder	University of Maryland, Baltimore	Completed	No outcome recorded
Phase 1/2	NCT02206152	Feb 2015 → Dec 2017	type 1 diabetes mellitus	University of Minnesota	Completed	No outcome recorded
Phase 1/2	NCT03014882	Feb 2015 → Dec 2017	DNA repair disease, endocrine system disorder, male infertility	Ain Shams University	Unknown	No outcome recorded
Phase 1/2	NCT01800526	Mar 2013 → Jan 2020	sickle cell disease	Bloodworks	Completed	No outcome recorded
Phase 1/2	NCT01384591	Jul 2011 → May 2015	—	The University of Texas Medical Branch, Galveston	Completed	No outcome recorded
Phase 1/2	NCT01322009	Mar 2011 → Dec 2013	traumatic brain injury	University of Pittsburgh	Completed	No outcome recorded
Phase 1/2	NCT00975689	Aug 2009 → Nov 2010	Niemann-Pick disease type C	Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)	Completed	No outcome recorded
Phase 1/2	NCT00724594	Aug 2008 → Jul 2014	brain injury, chorioamnionitis	Medical University of South Carolina	Completed	Missed primary
Phase 1/2	NCT00542750	Jan → Dec 2008	cannabis dependence	Medical University of South Carolina	Completed	No outcome recorded
Phase 1/2	NCT00467831	Apr 2007 → Nov 2012	Hermansky-Pudlak syndrome, oculocutaneous albinism, platelet storage pool deficiency, pulmonary fibrosis	National Human Genome Research Institute (NHGRI)	Terminated	No outcome recorded Stop: Enrollment
Phase 1/2	NCT00397735	Oct 2006 → Oct 2012	chorioamnionitis, preterm premature rupture of the membranes	Ohio State University	Completed	No outcome recorded
Phase 1/2	NCT00211653	Apr 2003 → Nov 2006	kidney failure	Minneapolis Veterans Affairs Medical Center	Completed	Missed primary

Phase 281 trials · 2 met primary · 12 missed
Phase 2	NCT07227649	Oct 2026 → Jan 2027 expected	Morton neuroma, carpal tunnel syndrome, de Quervain disease, disease of the tendon +4	University of Arizona	Not yet recruiting	No outcome recorded
Phase 2	NCT04381897	Aug 2026 → May 2027 expected	Cornelia de Lange syndrome	Johns Hopkins University	Not yet recruiting	No outcome recorded
Phase 2	NCT07567274	May → Jul 2026 overdue	tinnitus	Leading Edge Clinic	Enrolling by invitation	No outcome recorded
Phase 2	NCT06727422	Feb → Aug 2026 overdue	functional diarrhea, irritable bowel syndrome	Mark Pimentel, MD	Recruiting	No outcome recorded
Phase 2	NCT07117630	Sep 2025 → Jun 2027 expected	breast cancer	Fudan University	Recruiting	No outcome recorded
Phase 2	NCT06967428	Sep 2025 → Jan 2026 overdue	—	Independent Medical Alliance	Not yet recruiting	No outcome recorded
Phase 2	NCT07821853	Aug 2025 → Apr 2026	leptospirosis	Dr Cipto Mangunkusumo General Hospital	Completed	No outcome recorded
Phase 2	NCT06850831	Apr 2025 → Mar 2026	ST-elevation myocardial infarction	dr. Ahmad Yasa, Sp.JP, Subsp.K.I.(K), M.Kes, FIHA, FasCC, FA	Completed	No outcome recorded
Phase 2	NCT05074121	Mar → Dec 2024	COVID-19, pneumonia	Cambridge Health Alliance	Unknown	No outcome recorded
Phase 2	NCT06236165	Feb 2024 → Jan 2025	obstructive jaundice	Tanta University	Completed	No outcome recorded
Phase 2	NCT06482034	Jun 2023 → Sep 2024	mucositis	Mansoura University	Completed	No outcome recorded
Phase 2	NCT04964843	Apr 2023 → Jan 2025	alcohol-related disorders	Uniformed Services University of the Health Sciences	Withdrawn	No outcome recorded
Phase 2	NCT05736887	May 2022 → Jan 2023	COVID-19	Fondazione Policlinico Universitario Agostino Gemelli IRCCS	Unknown	No outcome recorded
Phase 2	NCT05340504	May 2022 → Jun 2023	bipolar I disorder, bipolar II disorder	Medical University of South Carolina	Completed	No outcome recorded
Phase 2	NCT04916080	Nov 2021 → Jun 2022	chronic kidney disease	Beni-Suef University	Completed	No outcome recorded
Phase 2	NCT04920448	Jun 2021 → Apr 2023	ischemic stroke	University Hospital, Caen	Terminated	No outcome recorded
Phase 2	NCT04712435	Apr 2021 → Mar 2023	disease related to hematopoietic stem cell transplant, hepatic veno-occlusive disease	Instituto Brasileiro de Controle do Cancer	Unknown	No outcome recorded
Phase 2	NCT04481048	Feb 2021 → Jun 2024	neurofibromatosis type 1	Children's Hospital Medical Center, Cincinnati	Completed	Missed primary
Phase 2	NCT04278898	Feb 2021 → Jul 2028 expected	autism spectrum disorder	Stanford University	Recruiting	No outcome recorded
Phase 2	NCT04155632	Dec 2020 → Mar 2023	substance-related disorder	Medical University of South Carolina	Completed	No outcome recorded
Phase 2	NCT04374461	May 2020 → May 2027 expected	COVID-19	Memorial Sloan Kettering Cancer Center	Active not recruiting	No outcome recorded
Phase 2	NCT04044131	Dec 2019 → Mar 2021	Alzheimer disease, Parkinson disease	Istanbul Medipol University Hospital	Completed	No outcome recorded
Phase 2	NCT04023266	Sep 2019 → Nov 2020	ST-elevation myocardial infarction	University of Alberta	Completed	No outcome recorded
Phase 2	NCT04291066	Sep 2019 → Apr 2020	traumatic brain injury	HonorHealth Research Institute	Completed	No outcome recorded
Phase 2	NCT04005053	Aug 2019 → May 2022	depressive disorder	University of Minnesota	Completed	No outcome recorded
Phase 2	NCT04330326	Jul 2019 → Jul 2020	NAFLD1	ScandiBio Therapeutics AB	Completed	No outcome recorded
Phase 2	NCT03423667	Mar 2019 → Dec 2024	cocaine dependence	Salvatore Campanella	Terminated	No outcome recorded Stop: Enrollment
Phase 2	NCT03702738	Mar 2019 → Dec 2021	pulmonary tuberculosis	The Aurum Institute NPC	Completed	No outcome recorded
Phase 2	NCT03707951	Feb 2019 → Feb 2024	alcohol-related disorders	Medical University of South Carolina	Completed	Missed primary
Phase 2	NCT04481035	Jan 2019 → Jun 2020	neurofibromatosis type 1	Children's Hospital Medical Center, Cincinnati	Completed	No outcome recorded
Phase 2	NCT03879759	Aug 2018 → Nov 2020	alcohol dependence	South West Sydney Local Health District	Unknown	No outcome recorded
Phase 2	NCT03008889	Jul 2018 → Sep 2019	autism spectrum disorder	Emory University	Completed	No outcome recorded
Phase 2	NCT03499249	May 2018 → Oct 2022	biliary atresia	Baylor College of Medicine	Completed	Missed primary
Phase 2	NCT07093944	Apr 2018 → Dec 2021	Parkinson disease	Kurdistan University of Medical Sciences	Completed	No outcome recorded
Phase 2	NCT03556371	Apr 2018 → Aug 2019	cocaine dependence	University of Concepcion, Chile	Completed	No outcome recorded
Phase 2	NCT03238300	Oct 2017 → Mar 2022	alcohol-related disorders	Medical University of South Carolina	Completed	Missed primary
Phase 2	NCT03220776	Aug 2017 → Nov 2022	alcohol-related disorders, bipolar disorder	Medical University of South Carolina	Completed	No outcome recorded
Phase 2	NCT03164421	Jan 2017 → Jun 2018	polycystic ovary syndrome	Zagazig University	Completed	Missed primary
Phase 2	NCT03281226	Dec 2016 → Jun 2019	AIDS, pulmonary tuberculosis	Fundação de Medicina Tropical Dr. Heitor Vieira Dourado	Unknown	No outcome recorded
Phase 2	NCT02966873	Oct 2016 → Sep 2021	alcohol abuse, post-traumatic stress disorder, substance dependence	Medical University of South Carolina	Completed	Missed primary
Phase 2	NCT02911285	Oct 2016 → Aug 2019	alcohol dependence, post-traumatic stress disorder	Medical University of South Carolina	Completed	No outcome recorded
Phase 2	NCT02791945	Aug 2016 → May 2018	alcohol-related disorders, traumatic brain injury	University of California, San Francisco	Completed	No outcome recorded
Phase 2	NCT02723162	May 2016 → Mar 2020	nicotine dependence	Medical University of South Carolina	Completed	No outcome recorded
Phase 2	NCT03121222	Nov 2015 → Feb 2016	inherited glutathione metabolism disease	Aristotle University Of Thessaloniki	Completed	No outcome recorded
Phase 2	NCT02583672	Sep 2015 → Dec 2025	Gaucher disease type I	University of Minnesota	Completed	No outcome recorded
Phase 2	NCT02379637	Jan → Apr 2015	common cold	Novartis	Completed	No outcome recorded
Phase 2	NCT02212678	Sep 2014 → Sep 2015	Parkinson disease	University of Minnesota	Completed	No outcome recorded
Phase 2	NCT02171104	Jul 2014 → Jan 2026 overdue	Hurler syndrome, Krabbe disease, Niemann-Pick disease type B, Niemann-Pick disease, type C2 +15	Masonic Cancer Center, University of Minnesota	Active not recruiting	No outcome recorded
Phase 2	NCT02707640	Aug 2013 → Feb 2015	idiopathic pulmonary fibrosis	Hoffmann-La Roche	Completed	No outcome recorded
Phase 2	NCT02499029	Feb 2013 → Sep 2014	post-traumatic stress disorder, substance dependence	Medical University of South Carolina	Completed	Met primary
Phase 2	NCT01664260	Nov 2012 → Dec 2016	post-traumatic stress disorder	Ewha Womans University	Withdrawn	No outcome recorded Stop: Enrollment
Phase 2	NCT01726465	Nov 2012 → Oct 2013	ischemic disease, liver cancer	Istituto Clinico Humanitas	Terminated	No outcome recorded
Phase 2	NCT01612221	Sep 2012 → Feb 2016	susceptibility to familial cutaneous melanoma	University of Utah	Completed	Missed primary
Phase 2	NCT01172275	Jul 2012 → Feb 2017	obsessive-compulsive disorder	Yale University	Completed	No outcome recorded
Phase 2	NCT01586533	Jun 2012 → Apr 2014	ulcerative colitis	Altheus Therapeutics, Inc.	Unknown	No outcome recorded
Phase 2	NCT01555970	Mar 2012 → Oct 2014	obsessive-compulsive disorder	University of Sao Paulo	Completed	Missed primary
Phase 2	NCT01495260	Sep 2011 → Nov 2013	adrenomyeloneuropathy	Pujol, Aurora, M.D.	Completed	No outcome recorded
Phase 2	NCT01704482	Feb 2011 → Sep 2012	impaired renal function disease, rheumatic heart disease	Assiut University	Completed	No outcome recorded
Phase 2	NCT01265563	Jan 2011 → Feb 2015	diabetic kidney disease, disorder of defective peroxisome oxidative status, proteinuria	VA Office of Research and Development	Completed	No outcome recorded
Phase 2	NCT01214083	Oct 2010 → Sep 2015	alcohol dependence	VA Office of Research and Development	Completed	No outcome recorded
Phase 2	NCT01172288	Jul 2010 → Jan 2014	Tourette syndrome	Yale University	Completed	Missed primary
Phase 2	NCT00993265	Oct 2009 → Apr 2012	trichotillomania	Yale University	Completed	Missed primary
Phase 2	NCT00967005	Sep 2009 → Sep 2012	nicotine dependence, pathological gambling	University of Chicago	Completed	Met primary
Phase 2	NCT00870883	Mar 2009 → May 2015	acute kidney injury, hypotensive disorder	Universidade do Extremo Sul Catarinense - Unidade Academica de Ciecias da Saude	Completed	No outcome recorded
Phase 2	NCT00676195	Jun 2008 → Jun 2010	autism	Stanford University	Completed	No outcome recorded
Phase 2	NCT01131468	Feb 2008 → Apr 2010	drug-induced hearing loss	TC Erciyes University	Completed	No outcome recorded
Phase 2	NCT00483314	Nov 2007 → Dec 2008	homocystinuria	McGill University Health Centre/Research Institute of the McGill University Health Centre	Completed	No outcome recorded
Phase 2	NCT00552786	Nov 2007 → Jan 2008	hearing loss, noise-induced, susceptibility to	National Taiwan University Hospital	Completed	No outcome recorded
Phase 2	NCT00780962	Oct 2007 → Aug 2010	—	Beth Israel Deaconess Medical Center	Completed	Missed primary
Phase 2	NCT00539188	Sep 2007 → Nov 2010	borderline personality disorder, stereotypic movement disorder	Yale University	Terminated	No outcome recorded
Phase 2	NCT00655928	Aug 2007 → Jul 2009	acute lung injury	Imperial College London	Completed	Missed primary
Phase 2	NCT00453180	Mar 2007 → Aug 2009	autism	Indiana University	Completed	No outcome recorded
Phase 2	NCT00751257	Dec 2006 → Oct 2007	nicotine dependence	Medical University of South Carolina	Completed	No outcome recorded
Phase 2	NCT00539513	Jun 2006 → Apr 2011	obsessive-compulsive disorder	Yale University	Terminated	No outcome recorded Stop: Enrollment
Phase 2	NCT00332605	Jun 2006 → Dec 2009	methamphetamine dependence	University of Chicago	Completed	No outcome recorded
Phase 2	NCT00218491	Nov 2005 → May 2010	cocaine dependence	Medical University of South Carolina	Completed	No outcome recorded
Phase 2	NCT00374088	Feb 2005 → Jun 2008	congenital heart disease, transposition of the great arteries	University of Michigan	Completed	No outcome recorded
Phase 2	NCT00332631	Aug 2004 → Mar 2006	—	Austin Health	Completed	No outcome recorded
Phase 2	NCT00187330	Mar 2004 → Aug 2005	heart disorder, impaired renal function disease	Sunnybrook Health Sciences Centre	Completed	No outcome recorded
Phase 2	NCT00196885	Dec 2003 → Dec 2006	Hodgkins lymphoma, bronchogenic carcinoma, digestive system neoplasm, non-Hodgkin lymphoma	German Cancer Research Center	Completed	No outcome recorded
Phase 2	NCT00122018	May 2002 → Mar 2006	acute kidney injury, chronic renal failure syndrome	Linda F. Barr, M.D.	Completed	No outcome recorded

Phase 2/325 trials · 1 met primary · 3 missed
Phase 2/3	NCT07156786	Sep 2025 → Apr 2027 expected	acute kidney injury, impaired renal function disease	Faculty of Medicine, University of Indonesia	Not yet recruiting	No outcome recorded
Phase 2/3	NCT06650384	Nov 2024 → Jan 2026	poisoning	Ain Shams University	Completed	No outcome recorded
Phase 2/3	NCT07279610	May 2024 → Dec 2026 expected	thrombotic microangiopathy	The First Affiliated Hospital of Soochow University	Active not recruiting	Met primary
Phase 2/3	NCT05494398	Mar 2024 → Jul 2028 expected	autism spectrum disorder	Stanford University	Enrolling by invitation	No outcome recorded
Phase 2/3	NCT06115408	Sep 2023 → Aug 2024	uterine corpus leiomyoma	Ain Shams University	Completed	No outcome recorded
Phase 2/3	NCT05686356	Jul 2023 → Jan 2026 overdue	tuberculosis	The Aurum Institute NPC	Active not recruiting	No outcome recorded
Phase 2/3	NCT05664789	Apr 2023 → Jan 2028 expected	autism spectrum disorder	Stanford University	Recruiting	No outcome recorded
Phase 2/3	NCT05738681	Sep 2022 → Mar 2023	drug-induced liver injury, hepatitis, tuberculosis	Mahidol University	Unknown	No outcome recorded
Phase 2/3	NCT04573153	Sep 2020 → May 2022	COVID-19	ScandiBio Therapeutics AB	Terminated	No outcome recorded Stop: Enrollment
Phase 2/3	NCT04405193	Oct 2019 → Jul 2020	methamphetamine dependence	Melva Louisa	Completed	No outcome recorded
Phase 2/3	NCT04531163	Oct 2019 → Nov 2020	diabetic kidney disease, type 2 diabetes mellitus	Al-Azhar University	Unknown	No outcome recorded
Phase 2/3	NCT03596125	Nov 2018 → Nov 2021	—	Nantes University Hospital	Terminated	No outcome recorded Stop: Enrollment
Phase 2/3	NCT03055377	Aug 2017 → Jan 2024	cannabis dependence	Medical University of South Carolina	Completed	Missed primary
Phase 2/3	NCT02505087	Sep 2015 → Apr 2018	SELENON-related myopathy	Assistance Publique - Hôpitaux de Paris	Terminated	No outcome recorded
Phase 2/3	NCT02182167	May 2014 → Feb 2019	drug-induced liver injury	University of Cape Town	Completed	No outcome recorded
Phase 2/3	NCT02040818	Nov 2013 → Jan 2017	—	University of California, San Diego	Withdrawn	No outcome recorded Stop: Enrollment
Phase 2/3	NCT01424033	Dec 2011 → Feb 2013	connective tissue disorder, interstitial lung disease	University of Michigan	Terminated	No outcome recorded
Phase 2/3	NCT01271088	Jun 2010 → Nov 2011	hearing loss disorder	TC Erciyes University	Completed	No outcome recorded
Phase 2/3	NCT01131572	Feb 2010 → Mar 2012	—	Lindner Center of HOPE	Terminated	Missed primary
Phase 2/3	NCT00532688	Sep 2007 → Feb 2008	chronic renal failure syndrome, congestive heart failure	Bayside Health	Unknown	No outcome recorded
Phase 2/3	NCT00497328	Aug 2007 → Jun 2013	acute tubulointerstitial nephritis	National University Hospital, Singapore	Completed	Missed primary
Phase 2/3	NCT00428883	Jan 2007 → Feb 2009	systemic sclerosis	Marche Polytechnic University	Unknown	No outcome recorded
Phase 2/3	NCT00556465	Jan → Jun 2007	diabetic kidney disease, type 2 diabetes mellitus	Shiraz University of Medical Sciences	Completed	No outcome recorded
Phase 2/3	NCT00267384	Mar 2006 → May 2008	—	Soroka University Medical Center	Completed	No outcome recorded
Phase 2/3	NCT00237614	Feb 2003 → May 2005	acute myocardial infarction	University of Milan	Completed	No outcome recorded

Phase 340 trials · 2 met primary · 7 missed
Phase 3	NCT07543458	Oct 2026 → Jul 2030 expected	arbovirus infection, dengue disease, hemorrhagic fever	Oxford University Clinical Research Unit, Vietnam	Not yet recruiting	No outcome recorded
Phase 3	NCT07737262	Sep 2026 → Sep 2028 expected	aplastic anemia	Peking University People's Hospital	Not yet recruiting	No outcome recorded
Phase 3	NCT06956482	May → Aug 2026 overdue	alcoholic hepatitis	University Hospital, Lille	Recruiting	No outcome recorded
Phase 3	NCT06836128	Mar 2025 → Feb 2026 overdue	polycystic ovary syndrome	Cairo University	Recruiting	No outcome recorded
Phase 3	NCT07325383	Aug 2024 → Mar 2025 overdue	disease related to hematopoietic stem cell transplant, mucositis	Tehran University of Medical Sciences	Active not recruiting	No outcome recorded
Phase 3	NCT05796401	Dec 2023 → Dec 2026 expected	psychotic disorder	Centre Hospitalier St Anne	Recruiting	No outcome recorded
Phase 3	NCT06165068	Dec 2023 → Dec 2025 overdue	dry age related macular degeneration	Navamindradhiraj University	Recruiting	No outcome recorded
Phase 3	NCT05537220	Oct 2023 → May 2029 expected	retinitis pigmentosa	Johns Hopkins University	Active not recruiting	No outcome recorded
Phase 3	NCT05706402	Sep 2023 → Sep 2025	chronic obstructive pulmonary disease	Queen Mary Hospital, Hong Kong	Unknown	No outcome recorded
Phase 3	NCT05907486	Aug 2023 → Aug 2025	thrombotic disease	The First Affiliated Hospital of Soochow University	Unknown	No outcome recorded
Phase 3	NCT05801055	Apr → Jun 2023	stomach disorder	Sanjay Gandhi Postgraduate Institute of Medical Sciences	Unknown	No outcome recorded
Phase 3	NCT05589584	Nov 2022 → May 2024	NAFLD1	Ain Shams University	Completed	No outcome recorded
Phase 3	NCT05460858	Apr 2021 → Sep 2023	disorder of defective peroxisome oxidative status, female infertility, ovarian endometriosis	Royan Institute	Unknown	No outcome recorded
Phase 3	NCT04756622	Apr 2021 → Dec 2022	chemotherapy-induced oral mucositis, disease related to hematopoietic stem cell transplant	moshe yeshurun	Unknown	No outcome recorded
Phase 3	NCT04300920	Dec 2020 → Mar 2026	idiopathic pulmonary fibrosis	Fernando J Martinez	Completed	No outcome recorded
Phase 3	NCT04455243	Aug 2020 → Aug 2021	COVID-19	King Saud University	Unknown	No outcome recorded
Phase 3	NCT03843541	Jun 2019 → Jan 2021	mucus inspissation of respiratory tract, respiratory system disorder	Zambon SpA	Completed	Met primary
Phase 3	NCT03956888	May 2019 → Dec 2023	chronic obstructive pulmonary disease	Siriraj Hospital	Completed	No outcome recorded
Phase 3	NCT03146130	Jan 2019 → Feb 2024	Parkinson disease, impulse control disorder	Centre Hospitalier Universitaire, Amiens	Terminated	No outcome recorded
Phase 3	NCT03680911	Oct 2018 → Jan 2020	anosmia, traumatic brain injury	University of Miami	Terminated	No outcome recorded
Phase 3	NCT03557229	Jul 2018 → Jun 2022	disorder of defective peroxisome oxidative status, infectious disease with sepsis	American British Cowdray Medical Center	Unknown	No outcome recorded
Phase 3	NCT03252925	Nov 2017 → Oct 2021	thrombotic microangiopathy	The First Affiliated Hospital of Soochow University	Completed	No outcome recorded
Phase 3	NCT03149107	Sep 2016 → Jan 2021	schizophrenia	University Hospital, Bonn	Terminated	No outcome recorded Stop: Enrollment
Phase 3	NCT02750319	Apr 2016 → Apr 2027 expected	—	Memorial Sloan Kettering Cancer Center	Active not recruiting	No outcome recorded
Phase 3	NCT02629536	Mar 2016 → Mar 2017	migraine disorder	University of Notre Dame Australia	Unknown	No outcome recorded
Phase 3	NCT03069300	Oct 2015 → Apr 2022	alcoholic hepatitis, infectious disease	Imperial College London	Unknown	No outcome recorded
Phase 3	NCT03862586	Feb 2015 → May 2017	female infertility	Royan Institute	Completed	No outcome recorded
Phase 3	NCT01849016	Apr 2013 → Jun 2016	sickle cell disease	Academic Medical Center - University of Amsterdam	Completed	No outcome recorded
Phase 3	NCT01878344	Jan 2013 → Jan 2018 overdue	ST-elevation myocardial infarction	Suleyman Demirel University	Active not recruiting	No outcome recorded
Phase 3	NCT01878669	Jan 2013 → Sep 2017 overdue	coronary artery disorder	Suleyman Demirel University	Active not recruiting	No outcome recorded
Phase 3	NCT01866644	Sep 2011 → Jun 2016	disease related to solid organ transplantation	La Fe Health Research Institute	Completed	Missed primary
Phase 3	NCT01232257	Jul → Dec 2011	chronic renal failure syndrome, end stage renal failure	A.C. Abrahams	Completed	No outcome recorded
Phase 3	NCT01033149	Dec 2009 → Mar 2012	bulimia nervosa	Lindner Center of HOPE	Terminated	Missed primary
Phase 3	NCT01082445	Aug 2009 → Nov 2010	ulcer of lower limbs	University of Turin, Italy	Completed	No outcome recorded
Phase 3	NCT00506506	Oct 2007 → Oct 2008	chronic kidney disease	London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's	Completed	Missed primary
Phase 3	NCT00998972	Sep 2006 → Dec 2010	chronic kidney disease	Institut d'Anesthesiologie des Alpes Maritimes	Completed	Missed primary
Phase 3	NCT00808795	Apr → Oct 2006	chronic kidney disease, diabetes mellitus	Tehran University of Medical Sciences	Completed	Missed primary
Phase 3	NCT00863785	Apr 2004 → Aug 2009	alcoholic hepatitis	Centre Hospitalier Universitaire, Amiens	Completed	Missed primary
Phase 3	NCT00639496	Mar 2000 → Jul 2003	idiopathic pulmonary fibrosis	Zambon SpA	Completed	Met primary
Phase 3	NCT00004467	Jun 1998 → Nov 2006	acute liver failure	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)	Completed	Missed primary

Phase 449 trials · 1 met primary · 5 missed
Phase 4	NCT07273071	Sep 2026 → Feb 2028 expected	infectious disease with sepsis	Theis S. Itenov	Recruiting	No outcome recorded
Phase 4	NCT07634991	Jan → Dec 2026 expected	diabetic retinopathy	Ain Shams University	Recruiting	No outcome recorded
Phase 4	NCT07508098	Jul 2025 → Jan 2026	hyperpigmentation of the skin	Pak Emirates Military Hospital	Completed	No outcome recorded
Phase 4	NCT06811675	Mar 2025 → Jun 2027 expected	carbon monoxide-induced delayed encephalopathy	China Medical University Hospital	Recruiting	No outcome recorded
Phase 4	NCT06083480	Dec 2024 → Sep 2028 expected	chronic pain syndrome, osteoarthritis, knee	Vanderbilt University Medical Center	Recruiting	No outcome recorded
Phase 4	NCT06546475	Aug 2024 → Jul 2027 expected	psychotic disorder	National Taiwan University Hospital	Not yet recruiting	No outcome recorded
Phase 4	NCT06384833	May 2024 → Sep 2025	rotator cuff syndrome	Mahidol University	Unknown	Missed primary
Phase 4	NCT06152653	Apr 2024 → Apr 2027 expected	asthma, chronic obstructive pulmonary disease	University of California, San Francisco	Recruiting	No outcome recorded
Phase 4	NCT06484530	Mar → Sep 2024 overdue	acetylation, slow, isoniazid toxicity, tuberculosis	Mahidol University	Recruiting	No outcome recorded
Phase 4	NCT06139952	Dec 2023 → Mar 2024	acute kidney tubular necrosis, coronary artery disorder	Ain Shams University	Completed	No outcome recorded
Phase 4	NCT05985759	Aug → Nov 2023	acute apical periodontitis	Bapuji Dental College & Hospital Davengere Karnataka	Unknown	No outcome recorded
Phase 4	NCT05408247	Feb 2023 → Nov 2025 overdue	alcohol-related disorders	University of Sydney	Recruiting	No outcome recorded
Phase 4	NCT05903014	Jan → Sep 2023	nicotine dependence	Indonesia University	Completed	No outcome recorded
Phase 4	NCT06956157	Jun 2022 → Nov 2024 overdue	obsessive-compulsive disorder	Guangdong Provincial People's Hospital	Active not recruiting	No outcome recorded
Phase 4	NCT04460521	Apr 2022 → Apr 2026 overdue	carpal tunnel syndrome	Emily Krauss	Recruiting	No outcome recorded
Phase 4	NCT04627922	Aug 2021 → Jun 2025	cannabis dependence, nicotine dependence	Ellen Herbst	Completed	No outcome recorded
Phase 4	NCT04226456	Jul 2021 → May 2023	drug-induced hearing loss, platinum-induced ototoxicity, tinnitus	Centre Hospitalier Universitaire Saint Pierre	Terminated	No outcome recorded Stop: Enrollment
Phase 4	NCT00956748	Nov 2019	discharging ear, otitis media	St. Paul's Hospital, Canada	Withdrawn	No outcome recorded
Phase 4	NCT05611086	Aug 2019 → Dec 2020	childhood acute lymphoblastic leukemia	Teny Tjitra Sari	Terminated	No outcome recorded
Phase 4	NCT03911414	Jun 2019 → Dec 2024	mood disorder	Massachusetts General Hospital	Completed	No outcome recorded
Phase 4	NCT03757585	May 2019 → May 2024	autism, non-verbal learning disability	Massachusetts General Hospital	Completed	No outcome recorded
Phase 4	NCT03652753	Jan 2019 → Dec 2026 expected	—	University of Missouri-Columbia	Recruiting	No outcome recorded
Phase 4	NCT03581084	Jul 2018	asthma	University of California, San Francisco	Terminated	No outcome recorded
Phase 4	NCT03494387	Apr 2018 → Mar 2020	—	University Hospital Bispebjerg and Frederiksberg	Completed	Missed primary
Phase 4	NCT03440268	Mar 2018 → Mar 2019	acute kidney injury, heart valve disorder	University of Sao Paulo General Hospital	Unknown	No outcome recorded
Phase 4	NCT03364218	Feb 2018 → May 2020	acute bronchiolitis	Carilion Clinic	Unknown	No outcome recorded
Phase 4	NCT03197103	Jul 2017 → Mar 2018	breasts and/or nipples, aplasia or hypoplasia of, 1	Centre of Postgraduate Medical Education	Unknown	Missed primary
Phase 4	NCT02505477	Feb 2017 → Jan 2023	schizophrenia	University of California, Los Angeles	Completed	No outcome recorded
Phase 4	NCT02889757	Jan 2017 → Dec 2018	drug-induced liver injury	Far Eastern Memorial Hospital	Unknown	No outcome recorded
Phase 4	NCT03018236	Jan 2017 → Jul 2018	alcohol dependence, cocaine dependence	Hospital de Clinicas de Porto Alegre	Unknown	No outcome recorded
Phase 4	NCT03221231	May 2016 → Feb 2022	cannabis dependence	University Hospital Brussels	Unknown	No outcome recorded
Phase 4	NCT03879356	Jan → Jun 2016	—	Assiut University	Completed	No outcome recorded
Phase 4	NCT02241876	Oct 2014 → Dec 2016	head and neck cancer	University of Campinas, Brazil	Unknown	No outcome recorded
Phase 4	NCT02249546	Sep 2014 → Aug 2016	Helicobacter pylori infectious disease	National Taiwan University Hospital	Unknown	Missed primary
Phase 4	NCT02971306	Jul 2014 → Dec 2017	alcoholic hepatitis	Post Graduate Institute of Medical Education and Research, Chandigarh	Unknown	Met primary
Phase 4	NCT02357290	Jan 2014 → Sep 2018	bipolar disorder	Massachusetts General Hospital	Completed	No outcome recorded
Phase 4	NCT01841411	Mar → Jun 2013	bacterial vaginosis	Minia University	Unknown	No outcome recorded
Phase 4	NCT01653171	Jul 2012 → Oct 2013	gastric neoplasm	Pontificia Universidad Catolica de Chile	Completed	No outcome recorded
Phase 4	NCT02761577	Jun 2012 → Jul 2013	kidney disorder	Clinical Hospital Centre Zagreb	Completed	No outcome recorded
Phase 4	NCT02239107	Jan 2012 → Dec 2013	polycystic ovary syndrome	Assiut University	Completed	No outcome recorded
Phase 4	NCT01339858	May 2011 → Dec 2015	schizoaffective disorder, schizophrenia, schizophreniform disorder	Indiana University	Completed	No outcome recorded
Phase 4	NCT01614431	Mar 2011 → Jan 2012	chronic kidney disease, nephropathic cystinosis	University of Sao Paulo	Completed	No outcome recorded
Phase 4	NCT01394419	Sep 2010 → Apr 2012	acute kidney injury	Yonsei University	Completed	Missed primary
Phase 4	NCT01111422	Mar → Dec 2010	end stage renal failure	Ewha Womans University	Unknown	No outcome recorded
Phase 4	NCT01047956	Jun 2009 → Jun 2010	opiate dependence	Taichung Veterans General Hospital	Unknown	No outcome recorded
Phase 4	NCT00866866	Mar → Dec 2009	—	University of Calgary	Unknown	No outcome recorded
Phase 4	NCT00190034	Jan 2005 → Jun 2007	acute kidney injury, cardiovascular disorder	Far Eastern Memorial Hospital	Suspended	No outcome recorded
Phase 4	NCT00188773	Jan 2004 → Aug 2007	metabolic syndrome X	University Health Network, Toronto	Completed	No outcome recorded
Phase 4	NCT00184977	Dec 1998 → Jan 2003	chronic bronchitis	Radboud University Medical Center	Completed	No outcome recorded

Phase not applicable53 trials · 4 met primary · 2 missed
—	NCT06909799	Apr 2025 → Dec 2027 expected	pulmonary tuberculosis	The Aurum Institute NPC	Recruiting	No outcome recorded
—	NCT06872372	Jan → Jul 2025 overdue	acute liver failure, drug-induced liver injury	Lahore General Hospital	Active not recruiting	No outcome recorded
—	NCT06581783	Dec 2024 → Feb 2025	—	Asian Institute of Gastroenterology, India	Completed	Met primary
—	NCT07323719	May 2024 → Dec 2025	atopic eczema	Cairo University	Completed	No outcome recorded
—	NCT06834711	Feb → Dec 2024	chronic apical periodontitis	Cukurova University	Completed	No outcome recorded
—	NCT07082621	Jan 2024 → Mar 2025	mucositis	Hams Hamed Abdelrahman	Completed	No outcome recorded
—	NCT07391163	Jan 2024 → Jan 2026	colorectal cancer	Tanta University	Completed	No outcome recorded
—	NCT06039280	Sep 2023 → Jul 2024	hepatocellular carcinoma	Institute of Liver and Biliary Sciences, India	Unknown	No outcome recorded
—	NCT06122311	Aug 2023 → Jun 2024	—	Helwan University	Completed	Met primary
—	NCT06019520	Aug 2023 → Feb 2024	poisoning	Foundation University Islamabad	Unknown	No outcome recorded
—	NCT05576428	Nov 2022 → Apr 2023	fatty liver disease	Dow University of Health Sciences	Unknown	No outcome recorded
—	NCT05539053	Nov 2022 → Nov 2023	chemotherapy-induced neuropathy	Department of Medical Services Ministry of Public Health of Thailand	Completed	No outcome recorded
—	NCT05294744	Oct 2022 → Jul 2026 overdue	alcoholic hepatitis	Bioaraba Health Research Institute	Recruiting	No outcome recorded
—	NCT07340944	Sep 2022 → Jan 2023	chronic apical periodontitis	Ataturk University	Completed	No outcome recorded
—	NCT07080190	Jul 2022 → Jun 2023	poisoning	South Valley University	Completed	No outcome recorded
—	NCT05951712	Jun → Aug 2022	mucositis	Asian Institute of Gastroenterology, India	Completed	No outcome recorded
—	NCT05370729	May 2022 → May 2024	—	Assiut University	Unknown	No outcome recorded
—	NCT05911282	Jun 2021	poisoning	University Medical Centre Ljubljana	Completed	No outcome recorded
—	NCT04570254	Aug → Dec 2020	COVID-19, acute respiratory distress syndrome, viral pneumonia	Unidad Temporal COVID-19 en Centro Citibanamex	Completed	No outcome recorded
—	NCT04764643	Feb 2020 → Apr 2021	esophageal squamous cell carcinoma	Xijing Hospital of Digestive Diseases	Completed	Met primary
—	NCT04170439	Nov 2019 → May 2020	—	Aljazeera Hospital	Completed	No outcome recorded
—	NCT04081012	May 2019 → May 2023	chronic thromboembolic pulmonary hypertension	Instituto Nacional de Cardiologia Ignacio Chavez	Unknown	No outcome recorded
—	NCT03759158	Dec 2018 → Jan 2019	cirrhosis of liver	Institute of Liver and Biliary Sciences, India	Completed	No outcome recorded
—	NCT02967094	Nov 2016 → Mar 2017	gastric cancer	Vitkovice Hospital	Unknown	Missed primary
—	NCT02865629	Aug 2016 → Aug 2019	depressive disorder	University of Cincinnati	Unknown	No outcome recorded
—	NCT02686385	Mar → Aug 2016	drug-induced liver injury	Institute of Liver and Biliary Sciences, India	Terminated	No outcome recorded
—	NCT02794389	Mar 2016 → Apr 2017	anorexia nervosa	University of Oxford	Completed	No outcome recorded
—	NCT03400709	Nov 2015 → Jun 2017	cisplatin toxicity, platinum-induced ototoxicity	Hospital San Juan de Dios, Santiago	Completed	No outcome recorded
—	NCT02972398	Sep 2015 → Jul 2023	major depressive disorder	Tianjin Anding Hospital	Unknown	No outcome recorded
—	NCT02015403	Dec 2013 → May 2015	liver disorder	Institute of Liver and Biliary Sciences, India	Completed	No outcome recorded
—	NCT02054949	Apr 2013 → Jan 2015	autism spectrum disorder, epilepsy	Nationwide Children's Hospital	Withdrawn	No outcome recorded
—	NCT01587001	Nov 2011 → Oct 2014	pulmonary sarcoidosis	National Jewish Health	Completed	No outcome recorded
—	NCT01394510	Jun 2011 → Sep 2014	disorder of defective peroxisome oxidative status, type 2 diabetes mellitus	Utzschneider, Kristina, M.D.	Completed	Missed primary
—	NCT01188005	Aug → Oct 2010	obstructive sleep apnea syndrome	University of Athens	Unknown	No outcome recorded
—	NCT01138956	Apr 2010 → Jun 2011	visceral leishmaniasis	Hospital Universitário Professor Edgard Santos	Unknown	No outcome recorded
—	NCT01359722	Mar 2010 → Dec 2011	acute kidney injury	Instituto do Coracao	Unknown	No outcome recorded
—	NCT01232790	Feb 2010 → Nov 2011	schizophrenia	Yale University	Completed	No outcome recorded
—	NCT00822263	Nov 2008 → Mar 2009	traumatic brain injury	Brooke Army Medical Center	Completed	Met primary
—	NCT00434005	Jul 2008 → Aug 2010	—	University of Washington	Completed	No outcome recorded
—	NCT00564642	Nov 2007 → Jan 2009	hepatitis, tuberculosis	National Research Institute of Tuberculosis and Lung Disease, Iran	Completed	No outcome recorded
—	NCT00498342	Jun 2007 → Jan 2008	chronic kidney disease	University of Vermont	Completed	No outcome recorded
—	NCT01008046	Apr 2007 → Jun 2009	polycystic ovary syndrome	Mansoura University	Completed	No outcome recorded
—	NCT00421785	Feb 2007 → Jan 2008	end stage renal failure	Assaf-Harofeh Medical Center	Unknown	No outcome recorded
—	NCT00493610	Nov 2006 → Jun 2008	hepatitis C virus infection	US Department of Veterans Affairs	Suspended	No outcome recorded Stop: Business
—	NCT00493727	Sep 2006 → Dec 2007	diabetes mellitus, proteinuria	US Department of Veterans Affairs	Completed	No outcome recorded
—	NCT00614757	May 2005 → Dec 2013	metabolic syndrome X	Midwest Biomedical Research Foundation	Suspended	No outcome recorded
—	NCT00131521	Jan 2005 → Dec 2007	mucus inspissation of respiratory tract	The University of Texas Health Science Center at San Antonio	Completed	No outcome recorded
—	NCT00572663	Jan 2005 → ?	chronic kidney disease, proteinuria	Medical University of Gdansk	Completed	No outcome recorded
—	NCT00353340	Jan 2005 → Jan 2008	acute kidney injury	Shaare Zedek Medical Center	Completed	No outcome recorded
—	NCT00736541	Jul 2004 → Apr 2007	liver failure	Ibtesam Hilmi	Completed	No outcome recorded
—	NCT00463671	Dec 2003 → Sep 2005	ulcer of lower limbs	Assaf-Harofeh Medical Center	Completed	No outcome recorded
—	NCT00592618	—	end stage renal failure, sleep apnea syndrome	Assaf-Harofeh Medical Center	Unknown	No outcome recorded
—	NCT00507052	—	kidney failure	Assaf-Harofeh Medical Center	Unknown	No outcome recorded

Comparator or background therapy115 trials
Phase 0	NCT05798481 Background	Mar 2024 → Apr 2025	hypertensive disorder	University of Alabama at Birmingham	Completed	No outcome recorded
Phase 0	NCT04987775 Comparator	Nov 2023 → Apr 2026 overdue	persian gulf syndrome	Nova Southeastern University	Recruiting	No outcome recorded
Phase 0	NCT05927259 Comparator	Jan 2022 → May 2023	organophosphate poisoning	Ain Shams University	Completed	No outcome recorded
Phase 0	NCT03253328 Comparator	Mar 2017 → Aug 2021	diabetes mellitus, limb ischemia, peripheral arterial disease	Washington University School of Medicine	Completed	No outcome recorded
Phase 0	NCT00609102 Comparator	Jul 2008 → Sep 2013	type 2 diabetes mellitus	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)	Completed	No outcome recorded
Show all 115 trials opens the full record — a long page

News releases announcing trial results or a regulatory action · 6

Date	Issuer	Release
2025-06-24	Zambon SpA	Regulatory Zambon Announces Approval and Launch in China of the Intravenous Formulation of Fluimucil® (N-acetylcysteine) zambon.com ↗ Zambon , a multinational chemical-pharmaceutical company founded on the history and values of an Italian family and committed to innovate cure and care to make patients’ lives better, announces the approval by Chinese regulatory authorities and the launch on the Chinese market of the intravenous (IV) formulation of Fluimucil® (N-acetylcysteine).
2024-12-10	Cumberland Pharmaceuticals	Regulatory IV Form of NAC Receives FDA sNDA to Prevent, Lessen Liver Injury After Ingesting Toxic Quantities of Acetaminophen cumberlandpharma.com ↗
2024-12-10	Cumberland Pharmaceuticals	Regulatory New Dosing Regimen for APAP Overdose Antidote Acetadote Approved cumberlandpharma.com ↗ The Food and Drug Administration (FDA) has approved a new dosing regimen for � {n-acetylcysteine [NAC] for injection), an antidote for acetaminophen overdose
2019-07-15	Egetis Therapeutics	Results The Lancet EBioMedicine publishes Aladote® study results egetis.com ↗ The combination of NAC and Aladote® was safe and tolerated.
2019-03-26	Egetis Therapeutics	Results Data from the POP study support further development of Aladote® as a new treatment option for reducing liver damage due to paracetamol overdose egetis.com ↗ The scientific rationale as well as clinical results from the completed POP study indicate that Aladote® in combination with N-acetylcysteine (NAC) has the potential to reduce liver damage in the specified patient population.
2018-07-21	Zydus Lifesciences Limited	Regulatory Zydus receives final approval from the USFDA for Acetylcysteine Injection zyduslife.com ↗ Zydus Cadila has received the final approval from the USFDA to market Acetylcysteine Injection (US RLD - Acetadote Injection ), 6 g/30 mL (200 mg/mL) .

All press releases naming this drug 8 releases

Date	Issuer	Release
2025-06-24	Zambon SpA	Zambon Announces Approval and Launch in China of the Intravenous Formulation of Fluimucil® (N-acetylcysteine) zambon.com ↗
2024-12-10	Cumberland Pharmaceuticals	IV Form of NAC Receives FDA sNDA to Prevent, Lessen Liver Injury After Ingesting Toxic Quantities of Acetaminophen cumberlandpharma.com ↗
2024-12-10	Cumberland Pharmaceuticals	New Dosing Regimen for APAP Overdose Antidote Acetadote Approved cumberlandpharma.com ↗
2019-07-15	Egetis Therapeutics	The Lancet EBioMedicine publishes Aladote® study results egetis.com ↗
2019-03-26	Egetis Therapeutics	Data from the POP study support further development of Aladote® as a new treatment option for reducing liver damage due to paracetamol overdose egetis.com ↗
2018-07-21	Zydus Lifesciences Limited	Zydus receives final approval from the USFDA for Acetylcysteine Injection zyduslife.com ↗
2013-01-07	Perrigo Company	Perrigo Announces Launch of Authorized Generic Version of Acetadote® (acetylcysteine) Injection perrigo.com ↗
2012-11-13	Perrigo Company	Perrigo Confirms Settlement Of Generic Version Of Acetadote® (acetylcysteine) Injection Patent Litigation perrigo.com ↗

Evidence & citations 27 cited values

Every value below carries the sentence it was read from. 471 sources stand behind the page.

Field	Value	Cited text
Known as	n-acetylcysteine	“The investigators are going to observe if add-on of n-acetylcysteine (NAC) 1200 or 2400 mg/d during tapering of antipsychotics in patients with remitted psychosis can help to...” NCT06546475 ↗ 480 “The randomized placebo-controlled IFIGENIA-trial demonstrated that therapy with high-dose N-acetylcysteine (NAC) given for one year, added to prednisone and azathioprine,...” PMID 19860915 ↗ Oct 2009 “Patients with an estimated glomerular filtration rate ≤30 mL · min(-1) · 1.73 m(-2) and/or a risk score ≥11 were randomly assigned to sodium bicarbonate solution and...” PMID 21844075 ↗ Aug 2011 “The objective of this study is to assess the efficacy of sodium bicarbonate compared with sodium chloride and oral N-acetylcysteine (NAC ) pretreatment for prevention of...” NCT00353340 ↗ “Previous studies found N-acetylcysteine (NAC), a slimy solvent ingredient in human body, by means of extra-cellular glutamate exchange mechanism, not only maintain glutamate...” NCT01047956 ↗ “We conducted a study to determine whether N-Acetyl-cysteine (NAC) protected men against noise-induced temporary threshold shift (TTS), and whether subgroups with genetic...” PMID 20638463 ↗ Jul 2010 “This study compares N-acetylcysteine (mucomyst) and sodium chloride to determine their efficacy in the prevention of pulmonary mucus obstruction and retention in intubated...” NCT00131521 ↗ “This study proposes a randomized, double-blind, placebo-controlled crossover trial to assess the effects of a prophylactic combination of N-acetylcysteine (600 mg) and...” PMID 24708640 ↗ Apr 2014 “Preclinical studies have demonstrated that N-acetylcysteine stabilizes levels of glutamate and glutathione and reduces alcohol-seeking behaviors, indicating it as a potential...” PMID 41128676 ↗ Dec 2025 “Comparison of Dexamethasone and N Acetylcysteine (NAC) Versus N Acetylcysteine (NAC) Alone in the Prevention of Post Embolization Syndrome in Patients With Hepatocellular...” NCT06039280 ↗ “Effect of N-acetylcysteine Versus Calcium Hydroxide Used as an Intracanal Medicament on the Intensity of Postoperative Pain, Bacterial Load Reduction and Levels of MMP -9 in...” NCT05666089 ↗ Show 470 more sources
Known as	ACC	“N-acetylcysteine (ACC) 1200 mg In the 8-weeks run-in period angiotensin converting enzyme inhibitors and/or angiotensin II subtype 1 receptor antagonists were administered to...” NCT00572663 ↗
Known as	ACC long	“600 mg of N-acetylcysteine (3 tablets of 200 mg ACC long)” NCT04641455 ↗
Known as	ACC-600	“Generic name: N-acetyl cysteine. Brand: ACC-600 (Acetylcysteine). Strength: 600mg per capsule. Form: capsule Route: oral Frequency: 2x capsules twice per day = total 4...” NCT05408247 ↗
Known as	Acetadote	“N-acetylcysteine (also known as Acetadote), an antioxidant medication” NCT00374088 ↗
Known as	Acetine	“N-Acetylcysteine (NAC)(Acetine, 1200mg/day) group and placebo one.” NCT00552786 ↗
Known as	acetylcysteine	“Generic name: N-acetyl cysteine. Brand: ACC-600 (Acetylcysteine). Strength: 600mg per capsule. Form: capsule Route: oral Frequency: 2x capsules twice per day = total 4...” NCT05408247 ↗ 1 “The procedure involved would be the administration of N-acetylcysteine via nebulization” NCT03346681 ↗
Known as	Acteylcysteine	“Drug: Acteylcysteine” NCT02889757 ↗
Known as	Fluimucil	“NAC (Fluimucil, Zambon Laboratories, São Paulo, Brazil)” NCT03440268 ↗
Known as	Flumucil	“NAC (N-Acetylcysteine Tablets, brand name: Flumucil) has a drug specification of 600 mg per tablet.” NCT06956157 ↗
Known as	Mucomyst	“This study compares N-acetylcysteine (mucomyst) and sodium chloride to determine their efficacy in the prevention of pulmonary mucus obstruction and retention in intubated...” NCT00131521 ↗ 2 “The study will look at the effect of 30 days of treatment of 15 diabetics with proteinuria with N-acetylcysteine ( Mucomyst ) at a dose of 1 gm twice a day by mouth.” NCT00493727 ↗ “The study will examine the effects of treatment with N-acetylcysteine ( Mucomyst ) 1 gm twice a day for 30 dyas in 15 patients with hepatitis C.” NCT00493610 ↗
Known as	N-acetyl cysteine (NAC)	“N-acetyl cysteine (NAC)” NCT03253328 ↗
Known as	N-Acetyl-L-Cysteine	“The purpose of this study is to examine the effectiveness of using a combination of a drug, rifaximin and a dietary supplement, N-acetyl-L-cysteine (NAC), to treat patients...” NCT06727422 ↗ 3 “This is a pilot study investigating the effect of an antioxidant, N-Acetyl-L-Cysteine (NAC), on inflammation and oxidative stress in sarcoidosis.” NCT01587001 ↗ “N-acetylcysteine (NAC), alternatively referred to as N-acetyl-L-cysteine, is an acetylated version of the amino acid L-cysteine” NCT07634991 ↗ “The Efficacy and Safety of N-acetyl-L-cysteine (NAC) as Adjuvant Therapy in Acute on Chronic Liver Failure (ACLF)” NCT05089981 ↗
Known as	N-AcetylCystein	“Prophylactic controlled hydration with saline (0.9%) plus N-acetylcystein (NAC; 6 g in total).” NCT01098032 ↗ 1 “N-AcetylCystein (NAC) is a scavenger of reactive oxygen species” NCT03440268 ↗
Known as	N-acetylcysteine 200 mg brand name Mysoven	“N-acetylcysteine 200 mg brand name Mysoven” NCT01597765 ↗
Known as	N-AcetylCysteyn	“N-AcetylCysteyn (NAC) for prevention of AKI” NCT03440268 ↗
Known as	N-Acetyle cystein	“N-Acetyle cystein (NAC) has an optimal thiol redox state” NCT05089981 ↗
Known as	N-acetyle cysteine	“Evaluation of gastric visibility following the combination drink of N-acetyle cysteine and simethocone” NCT05801055 ↗
Known as	NAC	“The investigators are going to observe if add-on of n-acetylcysteine (NAC) 1200 or 2400 mg/d during tapering of antipsychotics in patients with remitted psychosis can help to...” NCT06546475 ↗ 217 “Other drugs that can contribute to improve the situation of patients with this entity is N-acetylcysteine (NAC), however, in the different studies contradictory data are...” NCT05294744 ↗ “The randomized placebo-controlled IFIGENIA-trial demonstrated that therapy with high-dose N-acetylcysteine (NAC) given for one year, added to prednisone and azathioprine,...” PMID 19860915 ↗ Oct 2009 “The study intends to test the hypothesis that combined oral supplementation of the antioxidants N-acetylcysteine (NAC) and milk thistle flavonolignan silibin (as...” NCT01265563 ↗ “Participants in this group received N-Acetylcysteine (NAC) at a dose of 140 mg/kg orally or via a nasogastric tube every 4 hours for the first 16 hours, followed by the same...” NCT06872372 ↗ “The purpose of this study is to demonstrate the feasibility of a 9-week, randomized trial of N-acetylcysteine (NAC) compared to placebo in 14 children (age 5 to 12 years) with...” NCT03008889 ↗ “The aim of this study was to investigate the influence of perioperative N-acetylcysteine (NAC) administration, a known antioxidant, on the incidence of acute kidney injury...” PMID 25384603 ↗ Feb 2015 “The objective of this study is to assess the efficacy of sodium bicarbonate compared with sodium chloride and oral N-acetylcysteine (NAC ) pretreatment for prevention of...” NCT00353340 ↗ “Previous studies found N-acetylcysteine (NAC), a slimy solvent ingredient in human body, by means of extra-cellular glutamate exchange mechanism, not only maintain glutamate...” NCT01047956 ↗ “This study aims to evaluate the efficacy and safety of prophylactic oral N-acetylcysteine (NAC) for facilitating platelet engraftment in patients with severe aplastic anemia...” NCT07737262 ↗ “The primary objective of this study is to evaluate the impact of N-acetylcysteine (NAC) 1200 mg versus matched placebo (PBO) twice daily, added to contingency management (CM),...” NCT01675661 ↗ Show 207 more sources
Known as	Siran	“Siran (N-acetylcysteine)” NCT01251029 ↗
Known as	•Chemical Name: Cysteine, N-acetyl-, L	“•Chemical Name: Cysteine, N-acetyl-, L” NCT04481048 ↗
Known as	•Commercial Name(s): Acetin; Acetadote, Acetylcysteine; Airbron; Broncholysin; Fluimucetin; Fluimucil; Inspir; Mucomyst; Mucosolvin; NAC; Parvolex; Respaire	“•Commercial Name(s): Acetin; Acetadote, Acetylcysteine; Airbron; Broncholysin; Fluimucetin; Fluimucil; Inspir; Mucomyst; Mucosolvin; NAC; Parvolex; Respaire” NCT04481048 ↗
Known as	•Synonym:L-alpha-acetamido-beta-mercaptopropionic acid; Mercapturic acid; N-Acetyl-3-mercaptoalanine; N-Acetylcysteine	“•Synonym:L-alpha-acetamido-beta-mercaptopropionic acid; Mercapturic acid; N-Acetyl-3-mercaptoalanine; N-Acetylcysteine” NCT04481048 ↗
Action	Restore	“seems to restore the extracellular glutamate concentration in the nucleus accumbens” PMID 19581567 ↗ Jul 2009
Modality	Small molecule	“It is an acetylated form of amino acid L-cysteine, and is an excellent source of sulfhydryl groups.” NCT00493610 ↗
Route	Intravenous	“Patients are randomized to receive intravenous acetylcysteine or placebo for 72 hours.” NCT00004467 ↗
Target	MTOR	“profoundly reduced mTOR activity” PMID 22549432 ↗ Sep 2012