VitamIn and oXygen Interventions and Cardiovascular Events

Summary

This study examines the risks and benefits of antioxidants and normal versus high inspiratory oxygen fraction during anaesthesia.

Timeline

Start

2018-04-06

Primary completion

2020-03-01

Completion

2020-03-24

Outcome

Missed primary endpoint

paper HR 1.46 (95% CI, 0.79-2.70), p = 0.23. PMID 41055553 ↗

paper Antioxidants had a HR of 0.98 (95% CI, 0.54-1.80), p = 0.96 for all-cause mortality vs. placebo. PMID 41055553 ↗

Publications

• Loft FC, Holse C, Aasvang EK, Vester-Andersen M, Rasmussen LS, Jorgensen LN, Meyhoff CS. Effects of Hyperoxia and Antioxidants on Mortality, Hospital Admissions, and Myocardial Infarction After Noncardiac Surgery: 1-Year Follow-Up of a Randomized Controlled Trial. Acta Anaesthesiol Scand. 2025 Nov;69(10):e70118. doi: 10.1111/aas.70118.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	N-acetylcysteine	Small molecule	100 mg/kg	Intravenous
Subject	Oxygen	Other / unclassified	—	—
Subject	Vitamin C	Other / unclassified	3 g	Intravenous

Indications

No indication recorded.