Oxygen

also known as O(2) · 02 or Oxygen · Air/Oxygen · Dioxygen · E-948 · Equimolar Mixture of Nitrogen Protoxide and Oxygen · INS NO.948 · INS-948 · +15 more

Other / unclassified

Developed for: chronic obstructive pulmonary disease · traumatic brain injury · migraine disorder · polycythemia due to hypoxia · acute coronary syndrome · bronchiolitis · coronary artery disorder · COVID-19
+87 more
· critical illness polyneuropathy · idiopathic pulmonary fibrosis · interstitial lung disease · obstructive sleep apnea syndrome · pulmonary fibrosis · pulmonary hypertension · skin infection · ST-elevation myocardial infarction · acute respiratory failure · alternating hemiplegia of childhood · ampulla of vater neoplasm · ankle defects short stature · apnea of prematurity · articular cartilage disorder · avascular necrosis · branch retinal artery occlusion · breast cancer · calciphylaxis · cardiac arrest · cardiovascular disorder · central retinal vein occlusion · central sleep apnea syndrome · chronic cystitis · cluster headache syndrome · colonic pseudo-obstruction · Crohn disease · decompression sickness · decubitus ulcer · dermatitis · Ehlers-Danlos syndrome · enterocolitis · epidermolysis bullosa · fetal brain disruption sequence · fungal infectious disease · graft versus host disease · headache disorder · hypoplastic left heart syndrome · hypospadias · immune system disorder · inclusion body myositis · infectious disease with sepsis · inflammatory bowel disease · intermediate coronary syndrome · intestinal fistula · ischemic bowel disorder · ischemic disease · ligament disorder · malignant otitis externa · multiple sclerosis · nervous system disorder · neurodevelopmental disorder · non-arteritic anterior ischemic optic neuropathy · perinatal asphyxia · peripheral nerve lesion · pneumatosis cystoides intestinalis · post-COVID-19 disorder · pouchitis · prosthesis-related infectious disease · pterygium · pulmonary arterial hypertension · pulmonary embolism · pyoderma gangrenosum · radiation-induced disorder · Raynaud disease · respiratory failure · respiratory system disorder · retinitis pigmentosa · schizophrenia · tinnitus · traumatic encephalopathy · ulcer of anus and rectum · ulcerative colitis · vascular disorder · vasculitis · acute myocardial infarction · autoinflammatory syndrome · chronic thromboembolic pulmonary hypertension · congestive heart failure · heart failure · high altitude pulmonary edema · ischemic stroke · lumbar disk disease · middle lobe syndrome · pulmonary edema · pulmonary immaturity · respiratory distress syndrome in premature infants · sleep apnea syndrome
Investigated by: Medical University of Vienna · Insel Gruppe AG, University Hospital Bern · Karolinska Institutet · National Heart, Lung, and Blood Institute (NHLBI) · The Hospital for Sick Children · University of Zurich
+121 more
· Centre Hospitalier Universitaire de Nice · China Medical University, China · Duke University · LHL Helse · Massachusetts General Hospital · Monash University · Nova Scotia Health Authority · Ottawa Hospital Research Institute · Rigshospitalet, Denmark · University Hospital Southampton NHS Foundation Trust · University Hospital, Linkoeping · University of Birmingham · University of Modena and Reggio Emilia · Aalborg University Hospital · Aarhus University Hospital · Air Force Military Medical University, China · Air Liquide · Air Liquide SA · Albert Einstein Healthcare Network · Alberta Boehringer Ingelheim Collaboration · Ambulance Victoria · American Heart Association · Asklepios Kliniken Hamburg GmbH · Assistance Publique - Hôpitaux de Paris · Barry Miskin, MD · Baskent University Ankara Hospital · Beersheva Mental Health Center · Brigham and Women's Hospital · Case Western Reserve University · Centers for Medicare and Medicaid Services · Central Denmark Region · Climate Foundation · Cliniques universitaires Saint-Luc- Université Catholique de Louvain · Copenhagen Trial Unit, Center for Clinical Intervention Research · Copenhagen University Hospital, Hvidovre · Curtin University · Dalhousie University · Dartmouth College · Emergency Medicine Foundation · Erzincan Military Hospital · Flinders University · Florida Hospital Tampa Bay Division · Fondation de France · Francisco Andres de la Gala · Guangzhou Jeeyor Medical Research Co.,Ltd. · Göteborg University · Heart Foundation of Australia · Heart of England NHS Trust · Hospital St. Joseph, Marseille, France · Hospitales Universitarios Virgen del Rocío · IRCCS Burlo Garofolo · Instituto de Salud Carlos III · Istanbul University - Cerrahpasa · James A. Haley Veterans' Hospital (JAHVH) · Jay C. Buckey Jr. · Jupiter Medical Center · KTH Royal Institute of Technology · L'effet Papillon · Lady Hardinge Medical College · Mahidol University · Makerere University · Mallinckrodt · McMaster University · Nantes University Hospital · National Alliance for Research on Schizophrenia and Depression · National Health Service, United Kingdom · National Institute for Health Research, United Kingdom · National Institute of General Medical Sciences (NIGMS) · Norwegian Air Ambulance Foundation · Nova Southeastern University · Ontario Ministry of Health and Long Term Care · Oslo University Hospital · Parc de Salut Mar · Patient-Centered Outcomes Research Institute · all 127 on the full record

Regulatory milestones approvals, filings & regulatory actions · 1 recorded

Milestone	Jurisdiction	Brand	Indication	Date	Sentence it was read from
Approved	US (FDA)	OXYGEN, USP	—	2013-06-16	fda.gov ↗

Trials 101 · started per year

today

US approved 2013

20032004200520062007200820092010201120122013201420152016201720182019202020212022202320242025202620272028

Phase	Registry id	Dates	Indication	Sponsor	Status	Outcome
Phase 02 trials
Phase 0	NCT05891886	Oct 2023 → Jun 2027 expected	pulmonary embolism, venous thromboembolism	Massachusetts General Hospital	Recruiting	No outcome recorded
Phase 0	NCT02465749	May 2015 → Jun 2025	retinitis pigmentosa	Sun Yat-sen University	Unknown	No outcome recorded
Phase 15 trials · 1 missed
Phase 1	NCT05150418	Nov 2021 → Jun 2022	dehydration polycythemia	Oslo University Hospital	Completed	Missed primary
Phase 1	NCT06665633	Sep 2021 → Jul 2025	depressive disorder, traumatic brain injury	Nova Southeastern University	Completed	No outcome recorded
Phase 1	NCT03511846	Mar 2018 → May 2028 expected	SUNCT syndrome, cluster headache syndrome, hemicrania continua, migraine disorder +1	The University of Texas Health Science Center, Houston	Enrolling by invitation	No outcome recorded
Phase 1	NCT03386136	Jan 2018 → Oct 2019	colonic pseudo-obstruction	University of Florida	Completed	No outcome recorded
Phase 1	NCT02286544	Oct 2014 → Dec 2015	acute coronary syndrome, myocardial infarction	Karolinska Institutet	Completed	No outcome recorded
Phase 1/24 trials
Phase 1/2	NCT06327373	Jul 2026 → Jun 2027	pulmonary hypertension	Duke University	Withdrawn	No outcome recorded Stop: Business
Phase 1/2	NCT06109961	Jan 2024 → Jan 2026	inflammatory bowel disease	Ottawa Hospital Research Institute	Unknown	No outcome recorded
Phase 1/2	NCT03136835	Feb 2018 → Mar 2024	hypoplastic left heart syndrome	The Hospital for Sick Children	Completed	No outcome recorded
Phase 1/2	NCT01847755	Apr 2013 → Dec 2020	traumatic brain injury	Barry Miskin, MD	Completed	No outcome recorded
Phase 210 trials · 2 missed
Phase 2	NCT06053164	Jul 2025 → Sep 2026 overdue	pulmonary fibrosis	University of Alberta	Recruiting	No outcome recorded
Phase 2	NCT06248645	Sep 2024 → Mar 2026	alternating hemiplegia of childhood	Assistance Publique - Hôpitaux de Paris	Completed	No outcome recorded
Phase 2	NCT04094285	Oct 2019 → Jul 2024	—	Medical University of Vienna	Completed	No outcome recorded
Phase 2	NCT03189173	Sep 2017 → May 2023	obstructive sleep apnea syndrome	Brigham and Women's Hospital	Completed	No outcome recorded
Phase 2	NCT02499042	Jul 2015 → Aug 2017	cardiac arrest	Monash University	Completed	No outcome recorded
Phase 2	NCT02356900	Feb 2015 → May 2016	—	Duke University	Terminated	No outcome recorded Stop: Enrollment
Phase 2	NCT01542307	Jul 2012 → Sep 2015	migraine disorder	Massachusetts General Hospital	Completed	Missed primary
Phase 2	NCT02668029	Apr 2012 → Apr 2013	pulmonary fibrosis	University of Siena	Completed	No outcome recorded
Phase 2	NCT01306968	Feb 2011 → Aug 2012	traumatic brain injury, traumatic encephalopathy	U.S. Army Medical Research and Development Command	Completed	Missed primary
Phase 2	NCT01355809	Dec 2009 → Mar 2011	chronic obstructive pulmonary disease	Air Liquide SA	Terminated	No outcome recorded Stop: Enrollment
Phase 2/34 trials · 1 missed
Phase 2/3	NCT04500626	Apr 2021 → Aug 2022	COVID-19	Ottawa Hospital Research Institute	Unknown	No outcome recorded
Phase 2/3	NCT03483194	Sep 2018 → Apr 2020	hematopoietic and lymphoid cell neoplasm	Weprom	Completed	Missed primary
Phase 2/3	NCT02361944	Apr 2016 → Oct 2020	—	Vanderbilt University	Completed	No outcome recorded
Phase 2/3	NCT02468752	May 2015 → Apr 2019	decompression sickness, nervous system injury	Göteborg University	Completed	No outcome recorded
Phase 315 trials · 1 met primary · 2 missed
Phase 3	NCT06581003	Sep 2024 → Aug 2028 expected	traumatic brain injury	University of South Florida	Recruiting	No outcome recorded
Phase 3	NCT04597723	May 2022 → Jan 2023	—	Selcuk University	Unknown	No outcome recorded
Phase 3	NCT05185115	Apr 2022 → Oct 2026 expected	ankle defects short stature	Nantes University Hospital	Active not recruiting	No outcome recorded
Phase 3	NCT05430620	Mar 2022 → Jan 2025	ischemic disease, mitochondrial disease	Cliniques universitaires Saint-Luc- Université Catholique de Louvain	Unknown	No outcome recorded
Phase 3	NCT04256798	Nov 2020 → Oct 2025 overdue	pneumonia, skin infection	University of Birmingham	Recruiting	No outcome recorded
Phase 3	NCT04043299	Mar → Aug 2020	fetal brain disruption sequence, perinatal asphyxia	Makerere University	Unknown	No outcome recorded
Phase 3	NCT04193722	Aug 2019 → May 2023	breast cancer, radiation-induced disorder	UMC Utrecht	Completed	Missed primary
Phase 3	NCT02562781	Nov 2014 → Dec 2020	vascular disorder	Örebro University, Sweden	Completed	No outcome recorded
Phase 3	NCT02290080	Oct 2014 → Dec 2015	ST-elevation myocardial infarction, acute coronary syndrome, intermediate coronary syndrome	Karolinska Institutet	Completed	No outcome recorded
Phase 3	NCT01530971	Mar 2012 → Mar 2013	—	Mahidol University	Completed	No outcome recorded
Phase 3	NCT00692198	Jan 2009 → Aug 2015	chronic obstructive pulmonary disease	National Heart, Lung, and Blood Institute (NHLBI)	Completed	Missed primary
Phase 3	NCT00525863	Jan 2008 → Dec 2009	schizophrenia	Beersheva Mental Health Center	Unknown	No outcome recorded
Phase 3	NCT00116584	Dec 2004 → Mar 2008	bronchiolitis	University of Louisville	Completed	Met primary
Phase 3	NCT00626028	Sep 2004 → Feb 2010	cardiomyopathy, idiopathic pulmonary arterial hypertension	Mallinckrodt	Completed	Mixed
Phase 3	NCT00643786	Feb 2004 → May 2007	—	Air Liquide	Terminated	No outcome recorded

Phase 429 trials · 2 met primary · 2 missed
Phase 4	NCT07240649	Nov 2026 → Dec 2035 expected	COVID-19, Crohn disease, Raynaud disease, articular cartilage disorder +30	Jay C. Buckey Jr.	Not yet recruiting	No outcome recorded
Phase 4	NCT07280468	Mar 2026 → Jan 2030 expected	Down syndrome, obstructive sleep apnea syndrome	University of Arizona	Recruiting	No outcome recorded
Phase 4	NCT05703919	Jun 2025 → Feb 2028 expected	chronic obstructive pulmonary disease	Central Denmark Region	Recruiting	No outcome recorded
Phase 4	NCT07461779	Jan 2025 → Dec 2026 expected	—	Francisco Andres de la Gala	Recruiting	No outcome recorded
Phase 4	NCT06359106	Jul 2024 → Jun 2026 overdue	—	China Medical University, China	Recruiting	No outcome recorded
Phase 4	NCT04925414	Oct 2023 → Apr 2025 overdue	migraine disorder	Centre Hospitalier Universitaire de Nice	Recruiting	No outcome recorded
Phase 4	NCT06013098	Sep 2023 → Jan 2026	—	China Medical University, China	Completed	No outcome recorded
Phase 4	NCT05505032	Aug → Sep 2022	polycythemia due to hypoxia	Baskent University Ankara Hospital	Completed	No outcome recorded
Phase 4	NCT04890431	Mar 2022 → Oct 2023	Ehlers-Danlos syndrome	Hospital St. Joseph, Marseille, France	Unknown	No outcome recorded
Phase 4	NCT05146700	Dec 2021 → Oct 2023	—	Rigshospitalet, Denmark	Completed	Missed primary
Phase 4	NCT04425031	Aug 2020 → Mar 2023	acute respiratory failure	Aalborg University Hospital	Completed	Met primary
Phase 4	NCT04198077	Dec 2019 → Dec 2022	critical illness polyneuropathy	University of Modena and Reggio Emilia	Unknown	No outcome recorded
Phase 4	NCT03494387	Apr 2018 → Mar 2020	—	University Hospital Bispebjerg and Frederiksberg	Completed	Missed primary
Phase 4	NCT03552627	Mar 2018 → Dec 2026 expected	—	University Hospital Southampton NHS Foundation Trust	Active not recruiting	No outcome recorded
Phase 4	NCT03268590	Oct 2017 → May 2018	brain hypoxia - ischemia, neurodevelopmental disorder, polycythemia due to hypoxia	Case Western Reserve University	Completed	No outcome recorded
Phase 4	NCT03015051	Jan 2017 → Dec 2019	bronchiolitis	IRCCS Burlo Garofolo	Terminated	No outcome recorded Stop: Enrollment
Phase 4	NCT02509182	Dec 2016 → Jul 2017	polycythemia due to hypoxia	Yale University	Withdrawn	No outcome recorded
Phase 4	NCT03031626	Sep 2016 → Mar 2025	Prader-Willi syndrome, central sleep apnea syndrome	The Hospital for Sick Children	Completed	No outcome recorded
Phase 4	NCT02755389	Sep 2016 → Jun 2018	—	Nova Scotia Health Authority	Completed	No outcome recorded
Phase 4	NCT02143687	May 2014 → Oct 2021	interstitial lung disease, pulmonary hypertension	University of Zurich	Completed	No outcome recorded
Phase 4	NCT02150616	May 2014 → Dec 2020	interstitial lung disease, pulmonary arterial hypertension	University of Zurich	Unknown	No outcome recorded
Phase 4	NCT02619214	May 2013 → Dec 2015	disorder of defective peroxisome oxidative status	Sant Pau Research Institute	Unknown	No outcome recorded
Phase 4	NCT01722370	Aug 2012 → Nov 2014	chronic obstructive pulmonary disease	University of Birmingham	Completed	No outcome recorded
Phase 4	NCT01692821	Jun → Dec 2012	—	Medical University of Vienna	Completed	No outcome recorded
Phase 4	NCT01423929	Jan 2012 → Feb 2016	ST-elevation myocardial infarction	Region Skane	Completed	No outcome recorded
Phase 4	NCT01180192	May 2010	—	Erzincan Military Hospital	Unknown	No outcome recorded
Phase 4	NCT01319643	Dec 2009 → Nov 2010	cardiovascular disorder, immune system disorder, nervous system disorder, respiratory system disorder	University of Modena and Reggio Emilia	Unknown	Met primary
Phase 4	NCT00958178	Aug 2009 → Jun 2010	—	National Health Service, United Kingdom	Unknown	No outcome recorded
Phase 4	NCT01057420	Apr 2009 → Mar 2010	—	University of Zurich	Completed	No outcome recorded

Phase not applicable32 trials · 1 met primary · 2 missed
—	NCT07464730	Apr 2026 → Mar 2028 expected	—	Region Stockholm	Recruiting	No outcome recorded
—	NCT06643403	Sep 2024 → Dec 2025 overdue	—	Medical University of Vienna	Recruiting	No outcome recorded
—	NCT03800017	Aug 2024 → Dec 2026 expected	hypersensitivity pneumonitis, idiopathic pulmonary fibrosis, non-specific interstitial pneumonia, scleroderma	University of British Columbia	Recruiting	No outcome recorded
—	NCT05427760	Oct 2022 → Mar 2023	dermatitis	Istanbul University - Cerrahpasa	Completed	No outcome recorded
—	NCT04808401	May 2021 → Dec 2027 expected	coronary artery disorder	Insel Gruppe AG, University Hospital Bern	Recruiting	No outcome recorded
—	NCT04424433	Jun 2020 → Jun 2021	coronary artery disorder	Insel Gruppe AG, University Hospital Bern	Completed	No outcome recorded
—	NCT04564664	Mar 2019 → Dec 2020	idiopathic pulmonary fibrosis	Parc de Salut Mar	Completed	No outcome recorded
—	NCT03738722	Jan → Mar 2019	—	Insel Gruppe AG, University Hospital Bern	Completed	No outcome recorded
—	NCT03478774	Mar 2018 → Dec 2019	—	Insel Gruppe AG, University Hospital Bern	Completed	No outcome recorded
—	NCT03287466	Jan 2018 → Nov 2019	critical illness polyneuropathy, respiratory failure	University College, London	Completed	No outcome recorded
—	NCT03127371	Sep 2016 → Apr 2021	abscess	Albert Einstein Healthcare Network	Terminated	No outcome recorded Stop: Enrollment
—	NCT03312361	Apr 2016 → Apr 2018	altitude sickness, neuromuscular disease	The Hospital for Sick Children	Completed	No outcome recorded
—	NCT02625194	Jan 2016 → Sep 2017	lumbar spinal stenosis	Yonsei University	Completed	Met primary
—	NCT02553668	Oct 2015 → Oct 2016	—	University Hospital of Cologne	Unknown	No outcome recorded
—	NCT02743988	May 2015 → Apr 2017	apnea of prematurity	University of Ulm	Unknown	No outcome recorded
—	NCT02185118	Jun 2014 → Jun 2018	infectious disease with sepsis	Air Force Military Medical University, China	Unknown	No outcome recorded
—	NCT02108925	Apr 2014 → Mar 2016	chronic obstructive pulmonary disease	LHL Helse	Completed	No outcome recorded
—	NCT02575014	Oct 2013 → Dec 2018	ampulla of vater neoplasm	Florida Hospital Tampa Bay Division	Unknown	No outcome recorded
—	NCT01777568	Nov 2012 → Nov 2016	—	The Cleveland Clinic	Completed	Missed primary
—	NCT01690650	Sep 2012 → Aug 2013	—	Copenhagen University Hospital, Hvidovre	Completed	No outcome recorded
—	NCT02687217	Nov 2011 → Mar 2013	skin infection	Lady Hardinge Medical College	Completed	Missed primary
—	NCT01605110	Aug 2011 → Nov 2013	—	Restorix Research Institute, LLLP	Unknown	No outcome recorded
—	NCT00914407	Apr 2010 → Dec 2016	—	Medical University of Vienna	Completed	No outcome recorded
—	NCT01171118	Aug 2009 → Aug 2011	—	University of Rochester	Completed	No outcome recorded
—	NCT00822224	Jan 2009 → Dec 2011	dementia	Centre Hospitalier Universitaire de Nice	Completed	No outcome recorded
—	NCT00856232	Jan 2009 → May 2011	headache disorder	University of Medicine and Dentistry of New Jersey	Completed	No outcome recorded
—	NCT00719342	Jul 2008 → May 2009	—	Medical University of Vienna	Completed	No outcome recorded
—	NCT00249093	Oct 2005 → Apr 2007	chronic obstructive pulmonary disease	LHL Helse	Completed	No outcome recorded
—	NCT00394225	Jul 2005 → May 2006	chronic obstructive pulmonary disease	University of Saskatchewan	Completed	No outcome recorded
—	NCT00546299	Feb 2003 → Dec 2005	chronic obstructive pulmonary disease	West Park Healthcare Centre	Completed	No outcome recorded
—	NCT00406224	Dec 2002 → Dec 2003	—	Medical University of Vienna	Completed	No outcome recorded
—	NCT00431548	—	HIV infectious disease, retinal disorder	Medical University of Vienna	Completed	No outcome recorded

Comparator or background therapy91 trials
Phase 1	NCT06740305 Background	May → Aug 2025	decompression sickness	Duke University	Completed	No outcome recorded
Phase 1	NCT02473354 Background	Apr 2015 → Apr 2018	respiratory underresponsiveness to hypoxia and hypercapnia	Duke University	Completed	No outcome recorded
Phase 1	NCT01298921 Comparator	Jan 2011 → Jun 2012	cluster headache syndrome	Geisinger Clinic	Terminated	No outcome recorded Stop: Enrollment
Phase 1	NCT01157624 Comparator	May → Oct 2010	—	University of Malaya	Completed	No outcome recorded
Phase 1/2	NCT02065947 Comparator	Oct 2013 → Mar 2014	—	Ramathibodi Hospital	Completed	No outcome recorded
Phase 1/2	NCT01261377 Comparator	Nov 2010 → Sep 2011	chronic obstructive pulmonary disease	Brigham and Women's Hospital	Withdrawn	No outcome recorded
Phase 2	NCT06043440 Comparator	Oct 2023 → Nov 2027 expected	Down syndrome, obstructive sleep apnea syndrome	Brigham and Women's Hospital	Recruiting	No outcome recorded
Phase 2	NCT04378426 Background	Oct 2021 → Aug 2022	post-traumatic stress disorder	VA Office of Research and Development	Terminated	No outcome recorded
Phase 2	NCT04398290 Background	Dec 2020 → Jun 2021	COVID-19, respiratory failure	Roger Alvarez	Withdrawn	No outcome recorded
Phase 2	NCT03841084 Comparator	Sep 2019 → Jun 2023	heart failure	Australian and New Zealand Intensive Care Research Centre	Completed	No outcome recorded
Phase 2	NCT04207593 Comparator	Apr 2019 → Jan 2023	chronic thromboembolic pulmonary hypertension, pulmonary arterial hypertension	Heidelberg University	Completed	No outcome recorded
Phase 2	NCT02949531 Comparator	Nov 2016 → Feb 2017	heart failure	Hull University Teaching Hospitals NHS Trust	Completed	No outcome recorded
Phase 2	NCT01413841 Comparator	Jul 2011 → Jun 2012	coronary artery disorder	Region Skane	Completed	No outcome recorded
Phase 2	NCT00971607 Comparator	May 2009 → Dec 2013	acute myocardial infarction	London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's	Completed	No outcome recorded
Phase 2	NCT00566007 Comparator	Dec 2008 → Mar 2014	lumbar disk disease	Kovacs Foundation	Terminated	No outcome recorded
Phase 2	NCT00410150 Comparator	Apr 2006 → Dec 2007	status asthmaticus	Children's Hospital Medical Center, Cincinnati	Terminated	No outcome recorded Stop: Enrollment
Phase 2/3	NCT05613218 Comparator	Feb 2024 → Feb 2026	heart failure, pulmonary edema	Copenhagen University Hospital, Hvidovre	Completed	No outcome recorded
Phase 2/3	NCT01990404 Comparator	Jul 2013 → Dec 2015	—	University Hospital, Toulouse	Terminated	No outcome recorded Stop: Enrollment
Phase 2/3	NCT00515281 Background	May 2008 → Jun 2023	bronchopulmonary dysplasia, intracerebral hemorrhage, periventricular leukomalacia	University of Chicago	Terminated	No outcome recorded Stop: Enrollment
Phase 3	NCT07262008 Comparator	Feb 2026 → Feb 2027 expected	major depressive disorder	Women's College Hospital	Not yet recruiting	No outcome recorded
Phase 3	NCT05126459 Background	Feb 2022 → Apr 2023	anxiety, dental caries	Loma Linda University	Completed	No outcome recorded
Phase 3	NCT05335109 Comparator	Jan 2022 → Jan 2024	ischemic stroke	Negovsky Reanimatology Research Institute	Completed	No outcome recorded
Phase 3	NCT03745898 Comparator	Apr 2019 → Jun 2022	central sleep apnea syndrome, heart failure	Brigham and Women's Hospital	Terminated	No outcome recorded Stop: Enrollment
Phase 3	NCT03728894 Comparator	Nov 2018 → Jan 2019	—	Latakia University	Completed	No outcome recorded
Phase 3	NCT03102827 Comparator	Feb 2017 → Mar 2018	congestive heart failure	Heart and Diabetes Center North-Rhine Westfalia	Terminated	No outcome recorded
Phase 3	NCT02439866 Comparator	Feb 2014 → Jul 2015	non-arteritic anterior ischemic optic neuropathy	Shahid Beheshti University of Medical Sciences	Unknown	No outcome recorded
Phase 3	NCT01787110 Comparator	Apr 2013 → Dec 2016	ST-elevation myocardial infarction, acute coronary syndrome, intermediate coronary syndrome	Karolinska Institutet	Completed	No outcome recorded
Phase 3	NCT02424773 Background	Nov 2012 → Nov 2014	acute respiratory failure, immunodeficiency disease	Assistance Publique - Hôpitaux de Paris	Completed	No outcome recorded
Phase 3	NCT01155310 Comparator	May 2010 → Oct 2013	chronic obstructive pulmonary disease	Air Liquide	Terminated	Missed primary
Phase 3	NCT00643357 Background	Mar 2008 → Jan 2009	—	Air Liquide	Withdrawn	No outcome recorded Stop: Enrollment
Phase 3	NCT00392522 Background	Nov 2006 → ?	—	Hospices Civils de Lyon	Unknown	No outcome recorded
Phase 3	NCT00219713 Background	Mar 2000 → Dec 2004	—	Poitiers University Hospital	Terminated	No outcome recorded
Phase 4	NCT07210606 Comparator	Oct 2026 → Jun 2030 expected	central sleep apnea syndrome	VA Office of Research and Development	Not yet recruiting	No outcome recorded
Phase 4	NCT07186634 Comparator	Apr 2026 → Dec 2035 expected	—	Monash University	Recruiting	No outcome recorded
Phase 4	NCT07387315 Background	Feb → Nov 2026 expected	overactive bladder	TriHealth Inc.	Not yet recruiting	No outcome recorded
Phase 4	NCT05627024 Comparator	Jan 2023 → Jul 2024	middle lobe syndrome	China Medical University, China	Completed	No outcome recorded
Phase 4	NCT05052125 Comparator	Dec 2021 → Aug 2024	chronic obstructive pulmonary disease	Mikkel Brabrand	Terminated	No outcome recorded
Phase 4	NCT04957368 Comparator	Nov 2021 → Feb 2024	major depressive disorder	Unity Health Toronto	Completed	No outcome recorded
Phase 4	NCT04118387 Comparator	Jan 2021 → Dec 2026 expected	central sleep apnea syndrome	VA Office of Research and Development	Recruiting	No outcome recorded
Phase 4	NCT03941990 Background	Nov 2019 → Apr 2020	anxiety	University Hospital, Clermont-Ferrand	Unknown	No outcome recorded
Phase 4	NCT03840486 Comparator	Sep 2019 → Oct 2023	—	Emory University	Completed	No outcome recorded
Phase 4	NCT04133740 Comparator	Oct 2018 → Jul 2019	acute lung injury	Aalborg University Hospital	Unknown	No outcome recorded
Phase 4	NCT03441204 Comparator	May 2018 → Apr 2022	respiratory failure	Skane University Hospital	Completed	No outcome recorded
Phase 4	NCT03491644 Comparator	Apr → Jul 2018	—	Rigshospitalet, Denmark	Completed	No outcome recorded
Phase 4	NCT03366857 Comparator	Dec 2017 → Dec 2019	—	Medical University of Vienna	Completed	No outcome recorded
Phase 4	NCT03228628 Background	Oct 2017 → Jun 2018	anxiety	University Hospital, Clermont-Ferrand	Unknown	No outcome recorded
Phase 4	NCT03174002 Comparator	Jun 2017 → Nov 2020	acute respiratory failure	Aalborg University Hospital	Completed	No outcome recorded
Phase 4	NCT02378545 Comparator	Oct 2015 → Oct 2016	infectious disease with sepsis	University Hospital Plymouth NHS Trust	Completed	No outcome recorded
Phase 4	NCT02273830 Comparator	Sep 2015 → Oct 2017	chronic obstructive pulmonary disease	Jtarrega	Completed	No outcome recorded
Phase 4	NCT02321072 Comparator	Feb 2015 → Jan 2019	autoinflammatory syndrome	Amsterdam UMC, location VUmc	Completed	No outcome recorded
Phase 4	NCT02286063 Comparator	Aug 2014 → Jan 2018	pulmonary fibrosis	Royal Brompton & Harefield NHS Foundation Trust	Completed	No outcome recorded
Phase 4	NCT02243826 Background	Jul 2014 → Oct 2015	—	University Hospital, Clermont-Ferrand	Unknown	No outcome recorded
Phase 4	NCT02150590 Comparator	Jun → Oct 2014	chronic obstructive pulmonary disease	University of Zurich	Completed	No outcome recorded
Phase 4	NCT02143609 Comparator	May → Oct 2014	chronic obstructive pulmonary disease	University of Zurich	Completed	No outcome recorded
Phase 4	NCT02573987 Comparator	Mar 2013 → Apr 2015	—	Hospital St. Joseph, Marseille, France	Completed	No outcome recorded
Phase 4	NCT01087229 Background	Mar 2010 → Sep 2013	frozen shoulder	Nîmes University Hospital	Completed	Missed primary
Phase 4	NCT00637936 Comparator	Mar → Aug 2008	—	University of Copenhagen	Completed	No outcome recorded
Phase 4	NCT00547209 Background	Oct 2007 → Nov 2009	—	Hopital Foch	Completed	No outcome recorded
Phase 4	NCT00439075 Comparator	Oct 2006 → Apr 2008	pulmonary edema	University Hospital, Toulouse	Completed	No outcome recorded
Phase 4	NCT00364741 Comparator	Oct 2006 → Oct 2008	—	Rigshospitalet, Denmark	Completed	No outcome recorded
Phase 4	NCT00431691 Comparator	Sep 2006 → Dec 2007	escherichia coli infection, retinal disorder	Medical University of Vienna	Completed	No outcome recorded
Phase 4	NCT00732537 Comparator	Mar 1999 → Jun 2005	persistent fetal circulation syndrome, respiratory failure	University of Alabama at Birmingham	Completed	No outcome recorded
—	NCT07315594 Comparator	Nov 2026 → Jun 2029 expected	—	University of Alberta	Not yet recruiting	No outcome recorded
—	NCT06108791 Comparator	Apr 2025 → Jun 2026	—	Assiut University	Completed	No outcome recorded
—	NCT04307615 Comparator	Jul 2022 → Jul 2027 expected	high altitude pulmonary edema	Dalarna County Council, Sweden	Recruiting	No outcome recorded
—	NCT03825835 Comparator	Jun 2022 → Sep 2028 expected	neurodevelopmental disorder, pulmonary immaturity, respiratory distress syndrome in premature infants	University of Alberta	Active not recruiting	No outcome recorded
—	NCT05480566 Background	Jun 2022 → Dec 2023	chronic obstructive pulmonary disease	Hasselt University	Terminated	No outcome recorded
—	NCT04824703 Comparator	Apr 2021 → May 2023	—	Aswan University Hospital	Completed	No outcome recorded
—	NCT03956264 Comparator	Sep 2019 → Jul 2020	cardiac valvular defect	CMC Ambroise Paré	Completed	No outcome recorded
—	NCT07024914 Comparator	Sep 2019 → Dec 2025 overdue	chronic obstructive pulmonary disease	George Papanicolaou Hospital	Active not recruiting	No outcome recorded
—	NCT03683082 Comparator	Jun 2018 → Jun 2019	pulmonary arterial hypertension	George Papanicolaou Hospital	Unknown	No outcome recorded
—	NCT03688334 Comparator	Jun 2018 → Jun 2019	idiopathic pulmonary fibrosis	George Papanicolaou Hospital	Completed	No outcome recorded
—	NCT03239678 Comparator	Aug → Dec 2017	—	Sixth Affiliated Hospital, Sun Yat-sen University	Completed	No outcome recorded
—	NCT02741284 Comparator	Jun 2016 → Jun 2017	perinatal asphyxia, placental insufficiency	Washington University School of Medicine	Completed	No outcome recorded
—	NCT02534012 Background	May 2016 → Apr 2022	—	Makassed General Hospital	Unknown	No outcome recorded
—	NCT02752490 Comparator	Apr → Jul 2016	—	The University of Texas Health Science Center, Houston	Completed	No outcome recorded
—	NCT02460055 Comparator	Mar → Jun 2016	lung disorder	Baylor College of Medicine	Withdrawn	No outcome recorded Stop: Enrollment
—	NCT03020212 Comparator	Feb 2016 → Jan 2025	chronic obstructive pulmonary disease	Fundación Neumologica Colombiana	Completed	No outcome recorded
—	NCT02410707 Background	Feb 2015 → Feb 2018	abscess	Albert Einstein Healthcare Network	Completed	No outcome recorded
—	NCT02355678 Background	Jan → Aug 2015	—	Makassed General Hospital	Completed	Missed primary
—	NCT02233634 Comparator	Oct 2014 → Nov 2017	coronary artery disorder	Insel Gruppe AG, University Hospital Bern	Completed	No outcome recorded
—	NCT02236260 Background	Sep 2014 → Jun 2017	Parkinson disease	Nantes University Hospital	Completed	No outcome recorded
—	NCT02244957 Comparator	Sep 2014 → Feb 2017	chronic obstructive pulmonary disease, obstructive sleep apnea syndrome	University of California, San Diego	Completed	No outcome recorded
—	NCT01751971 Comparator	Nov 2012 → Jul 2016	sleep apnea syndrome	Brigham and Women's Hospital	Completed	No outcome recorded
—	NCT01722422 Comparator	Oct 2012 → Sep 2014	adult acute respiratory distress syndrome, infectious disease with sepsis	University Hospital, Angers	Terminated	No outcome recorded
—	NCT01636999 Background	Sep 2012 → Sep 2014	—	West Penn Allegheny Health System	Withdrawn	No outcome recorded
—	NCT01611064 Comparator	Feb → Jun 2012	—	University of Oxford	Completed	No outcome recorded
—	NCT01511627 Comparator	Jan → Jul 2012	—	University of Saskatchewan	Withdrawn	No outcome recorded
—	NCT02150434 Comparator	Nov 2009 → May 2012	chronic obstructive pulmonary disease	Laval University	Completed	No outcome recorded
—	NCT00874172 Background	Oct 2009 → Oct 2012	sickle cell disease	Assistance Publique - Hôpitaux de Paris	Completed	No outcome recorded
—	NCT01448889 Comparator	Sep 2009 → Sep 2012	—	Assaf-Harofeh Medical Center	Unknown	No outcome recorded

Press releases naming this drug 1 release

Date	Issuer	Release
2023-10-25	Xenothera SAS	[Press Release] French biotech announces its therapeutic potential for oxygen-free patients xenothera.com ↗

Evidence & citations 27 cited values

Every value below carries the sentence it was read from. 195 sources stand behind the page.

Field	Value	Cited text
Known as	Oxygen	“Patients were randomized to receive either usual care, including conventional optimal treatment with furosemide, oxygen, and high-dose boluses of isosorbide dinitrate plus...” PMID 20825901 ↗ May 2010 183 “All patients will receive injectable paracetamol for pain relief, a mix of nitrous oxide 50% and oxygen 50% for analgesia and lidocaine hydrochloride for local anesthesia.” NCT02236260 ↗ “Patients are randomized between two daily durations of oxygen used in current clinical practice: LTOT 24 h/day (intervention) or 15 h/day (control).” NCT03441204 ↗ “Patients will be randomly assigned to receive either 100% oxygen by mask (treated group) or breath room air (control group).” NCT01448889 ↗ “Anesthesia is maintained by 1-1.5% sevoflurane, 0.5 µg/kg/h fentanyl, 0.05 mg/kg/h nimbex, 60% nitrous oxide and 40% oxygen.” NCT02534012 ↗ “administeration via inhalation of Nitrous oxide/oxygen (30-50% N2O/ 70-50% O2) via inhalation” NCT05126459 ↗ “Maintenance with sevoflurane 1-3%, fentanyl (1-2 µg kg-1), nitrous oxide 70% and oxygen 30%.” NCT02355678 ↗ “Inhalated gas, medicinal oxygen 100% via NIV with Fi O2 0.35, one time by random, 6 minutes” NCT01355809 ↗ “the concentration of intraoperative inspired fraction of oxygen is 80% oxygen + 20% air” NCT06108791 ↗ “Maintenance of anesthesia with sevoflurane, oxygen and air” NCT01511627 ↗ “60% nitrous oxide combined with 40% oxygen for ventilation” NCT00547209 ↗ Show 173 more sources
Known as	02 or Oxygen	“02 or Oxygen” NCT01847755 ↗
Known as	Air/Oxygen	ClinicalTrials.gov intervention name — accepted as the source's own label NCT01155310 ↗
Known as	Dioxygen	ChEMBL registry synonym — accepted as the source's own label CHEMBL1234886 ↗
Known as	E-948	ChEMBL registry synonym — accepted as the source's own label CHEMBL1234886 ↗
Known as	Equimolar Mixture of Nitrogen Protoxide and Oxygen	“Use of MEOPA (Equimolar Mixture of Nitrogen Protoxide and Oxygen) for Elderly With Dementia” NCT00822224 ↗
Known as	INS NO.948	ChEMBL registry synonym — accepted as the source's own label CHEMBL1234886 ↗
Known as	INS-948	ChEMBL registry synonym — accepted as the source's own label CHEMBL1234886 ↗
Known as	Medicinal oxygen air liquide sante	ChEMBL registry synonym — accepted as the source's own label CHEMBL1234886 ↗
Known as	MEOPA	ClinicalTrials.gov intervention name — accepted as the source's own label NCT00822224 ↗
Known as	Molecular oxygen	ChEMBL registry synonym — accepted as the source's own label CHEMBL1234886 ↗
Known as	NBO	“Subjects will be consented to inhale either Normobaric Oxygen (NBO) or Room air for 30 minutes at the start of their migraine attacks.” NCT01542307 ↗
Known as	Normobaric Oxygen	“Subjects will be consented to inhale either Normobaric Oxygen (NBO) or Room air for 30 minutes at the start of their migraine attacks.” NCT01542307 ↗
Known as	O(2)	“All patients were tested with each of three agents (80 ppm iNO, 100% O(2), combination of 80 ppm iNO/100% O(2)) in three 10-min treatment periods, and hemodynamic measurements obtained.” PMID 20405117 ↗ Apr 2010 3 NCT00431548 ↗ NCT03728894 ↗ NCT00431691 ↗
Known as	Oxygen 93 percent	ChEMBL registry synonym — accepted as the source's own label CHEMBL1234886 ↗
Known as	OXYGEN COMPONENT OF RNS-60	ChEMBL registry synonym — accepted as the source's own label CHEMBL1234886 ↗
Known as	Oxygen molecule	ChEMBL registry synonym — accepted as the source's own label CHEMBL1234886 ↗
Known as	Oxygen supplementation	“Drug: Oxygen supplementation” NCT03683082 ↗
Known as	Oxygen/nitrous oxide equimolar mix	ClinicalTrials.gov intervention name — accepted as the source's own label NCT02573987 ↗
Known as	Oxygenium	ChEMBL registry synonym — accepted as the source's own label CHEMBL1234886 ↗
Known as	Oxygène	ClinicalTrials.gov intervention name — accepted as the source's own label NCT00643786 ↗
Known as	PL 15929/005	“The IMP investigated in this study is medical oxygen (PL 15929/005), manufactured by Air Liquide Ltd. UK.” NCT02286063 ↗
Known as	Premixed 50% nitrous oxide and oxygen	ClinicalTrials.gov intervention name — accepted as the source's own label NCT01990404 ↗
Known as	SAUERSTOFF	ClinicalTrials.gov intervention name — accepted as the source's own label NCT04094285 ↗
Action	Inhibit	“100% oxygen or 0.5 MAC isoflurane/sevoflurane in 60% oxygen would inhibit increases of tumor necrosis factor (TNF)-alpha, interleukin-1beta, interleukin-6 in the cell culture...” NCT02185118 ↗
Modality	Other / unclassified	“oxygen inhalation via HFNC” PMID 22147778 ↗ Dec 2011
Route	Inhaled	“After nebulization, humidified helium-oxygen or oxygen was delivered by HFNC.” PMID 22147778 ↗ Dec 2011