Effect of Ambulatory Oxygen on the Walking Test in Patients With Pulmonary Fibrosis

Summary

Patients with pulmonary fibrosis often desaturate on exercise. There are no data showing whether ambulatory oxygen can be useful to improve exercise capacity in this condition. Ambulatory ambulatory oxygen is often denied to these patients based on studies conducted on patients with chronic obstructive pulmonary disease, a completely different condition for physiopathology, prognosis, and response to therapy. We therefore planned a controlled study to verify the usefulness of ambulatory oxygen in patients with pulmonary fibrosis

Timeline

Start

2012-04

Primary completion

2013-04

Completion

2013-04

Publications

• Background Guyatt GH, Nonoyama M, Lacchetti C, Goeree R, McKim D, Heels-Ansdell D, Goldstein R. A randomized trial of strategies for assessing eligibility for long-term domiciliary oxygen therapy. Am J Respir Crit Care Med. 2005 Sep 1;172(5):573-80. doi: 10.1164/rccm.200412-1692OC. Epub 2005 May 18.
• Ciarleglio G, Cameli P, Bennett D, Cekorja B, Rottoli P, Renzoni EA, Sestini P, Bargagli E. Objective Effects and Patient Preferences for Ambulatory Oxygen in Fibrotic Interstitial Lung Disease With Isolated Exertional Hypoxaemia: A Placebo-Controlled 6-Minute Walk Test Study. Respirology. 2025 Jul;30(7):644-651. doi: 10.1111/resp.70020. Epub 2025 Mar 11.

Drugs

Indications