Inhaled Nitric Oxide and Neuroprotection in Premature Infants

Summary

The purpose of this study is to determine whether inhaled nitric oxide improves the neurological outcome for premature infants.

Timeline

Start

2008-05

Primary completion

2023-06-07

Completion

2023-11-28

Outcome

Outcome not reported

Stopped (Enrollment): “The pace of patient enrolledment forced recruitment to stop after 273 patients.”

Publications

• Background Schreiber MD, Gin-Mestan K, Marks JD, Huo D, Lee G, Srisuparp P. Inhaled nitric oxide in premature infants with the respiratory distress syndrome. N Engl J Med. 2003 Nov 27;349(22):2099-107. doi: 10.1056/NEJMoa031154.
• Background Mestan KK, Marks JD, Hecox K, Huo D, Schreiber MD. Neurodevelopmental outcomes of premature infants treated with inhaled nitric oxide. N Engl J Med. 2005 Jul 7;353(1):23-32. doi: 10.1056/NEJMoa043514.

Drugs

Indications