Comparison of Inhaled Nitric Oxide and Oxygen in Participants Reactivity During Acute Pulmonary Vasodilator Testing

Summary

The primary purpose of this study is to compare the number of participants with reversible pulmonary hypertension (vasoreactivity) due to nitric oxide for inhalation and oxygen as compared to 100% oxygen.

Timeline

Start

2004-09

Primary completion

2010-02

Completion

2010-02

Outcome

Mixed primary results

paper more acute responders were identified with the iNO/O(2) combination vs. O(2) alone. PMID 20405117 ↗

paper 26% vs. 14%, P = 0.019 PMID 20405117 ↗

paper While there was no significant difference in acute responder rate with iNO alone vs. iNO/O(2) PMID 20405117 ↗

paper 27% vs. 24%, P = 0.602 PMID 20405117 ↗

Publications

• Barst RJ, Agnoletti G, Fraisse A, Baldassarre J, Wessel DL; NO Diagnostic Study Group. Vasodilator testing with nitric oxide and/or oxygen in pediatric pulmonary hypertension. Pediatr Cardiol. 2010 Jul;31(5):598-606. doi: 10.1007/s00246-010-9645-5. Epub 2010 Apr 20.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Nitric Oxide	Other / unclassified	80 ppm	Inhaled
Subject	Oxygen	Other / unclassified	100 %	Inhaled

Indications