Dexamethasone Versus Local Infiltration Technique for Tonsillectomy in Children
Summary
Tonsillectomy is one of the most frequent surgical operations performed in children \[1-4\]. It is usually associated with postoperative nausea and vomiting (PONV) with an incidence ranging from 23% to 73% \[2\]. Dexamethasone has been shown to be effective in reducing PONV after tonsillectomy using standardized anesthetic technique \[2, 5-7\]. Previous studies utilizing a different technique, the pre-incision infiltration of local anesthesia, had shown to decrease post-tonsillectomy pain, reduce analgesic consumption and provide a rapid return to normal activity \[8, 9\]. Given the effectiveness of dexamethasone and the pre-incision infiltration anesthetic technique, it would be beneficial to compare the effect of each on PONV.
Timeline
- Start
- 2015-01
- Primary completion
- 2015-08
- Completion
- 2015-08
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Bupivacaine | Other / unclassified | — | Other |
| Subject | Clonidine | Other / unclassified | — | Other |
| Subject | Dexamethasone | Small molecule | 0.5 mg/kg | Intravenous |
| Subject | Fentanyl | Other / unclassified | — | Intravenous |
| Subject | Lidocaine | Other / unclassified | — | Other |
| Background | Acetaminophen | Small molecule | 350 mg | Rectal |
| Background | Atracurium | Small molecule | 0.5 mg/kg | Intravenous |
| Background | Nitrous Oxide | Other / unclassified | 70 % | — |
| Background | Oxygen | Other / unclassified | 30 % | — |
| Background | Propacetamol | Small molecule | 15 mg/kg | Intravenous |
| Background | Propofol | Small molecule | 2.5 mg/kg | Intravenous |
| Background | Sevoflurane | Other / unclassified | — | — |
| Background | Tramadol | Other / unclassified | — | — |
Indications
No indication recorded.