Drugs / Atracurium
Atracurium
Regulatory milestones approvals, filings & regulatory actions · 4 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Label expansions (3) | US (FDA) | TRACRIUM PRESERVATIVE FREE | — | 1986-02-14 – 1994-06-06 | fda.gov ↗ |
| Approved | US (FDA) | TRACRIUM PRESERVATIVE FREE | — | 1983-11-23 | fda.gov ↗ |
Trials 6
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 01 trial | ||||||
| Phase 0 | NCT05097508 | Jun 2020 → Jun 2021 | — | Ain Shams University | Completed | No outcome recorded |
| Phase 21 trial | ||||||
| Phase 2 | NCT01273831 | Jul → Dec 2009 | — | Isfahan University of Medical Sciences | Completed | No outcome recorded |
| Phase 31 trial | ||||||
| Phase 3 | NCT02920905 | Nov 2015 → Apr 2017 | — | Assiut University | Completed | No outcome recorded |
| Phase 42 trials | ||||||
| Phase 4 | NCT02404142 | Feb 2015 → Apr 2016 | — | Reims University Hospital | Completed | No outcome recorded |
| Phase 4 | NCT02004015 | Nov 2013 → Apr 2015 | — | Fondation Ophtalmologique Adolphe de Rothschild | Terminated | No outcome recorded |
| Phase not applicable1 trial | ||||||
| — | NCT01147146 | Jun → Dec 2010 | — | Yonsei University | Completed | No outcome recorded |
| Comparator or background therapy48 trials | ||||||
| Phase 1/2 | NCT02065947 Comparator | Oct 2013 → Mar 2014 | — | Ramathibodi Hospital | Completed | No outcome recorded |
| Phase 2 | NCT04545424 Background | Jun 2021 → Jun 2026 overdue | adult acute respiratory distress syndrome | University of Maryland, Baltimore | Active not recruiting | No outcome recorded |
| Phase 2 | NCT03376854 Background | May 2018 → Apr 2021 | COVID-19, adult acute respiratory distress syndrome | University of Maryland, Baltimore | Withdrawn | No outcome recorded |
| Phase 2 | NCT02036736 Background | Apr 2013 → Dec 2014 | — | Assistance Publique - Hôpitaux de Paris | Completed | No outcome recorded |
| Phase 2/3 | NCT02700893 Comparator | Mar → Aug 2016 | cerebrovascular disorder | Centre Hospitalier Intercommunal Creteil | Completed | Missed primary |
| Phase 2/3 | NCT01490580 Comparator | May 2012 → Aug 2016 | — | Centre Hospitalier Intercommunal Creteil | Completed | Missed primary |
| Phase 4 | NCT07496593 Comparator | Dec 2025 → Dec 2026 expected | diabetes mellitus | Ain Shams University | Active not recruiting | No outcome recorded |
| Phase 4 | NCT06202664 Comparator | Jan → Aug 2024 | — | Muhammad Haroon Anwar | Completed | No outcome recorded |
| Phase 4 | NCT05897151 Comparator | Jun → Nov 2023 | infectious disease with sepsis | Mahmoud Rashad Ahmed | Unknown | No outcome recorded |
| Phase 4 | NCT05019560 Comparator | Sep → Nov 2021 | — | Ain Shams University | Completed | No outcome recorded |
| Phase 4 | NCT04365686 Background | Apr 2019 → Apr 2020 | — | Fayoum University Hospital | Completed | No outcome recorded |
| Phase 4 | NCT03371953 Comparator | Dec 2017 → Oct 2018 | — | Sir Ganga Ram Hospital | Unknown | No outcome recorded |
| Phase 4 | NCT03243500 Comparator | May 2015 → May 2016 | — | Kasr El Aini Hospital | Completed | No outcome recorded |
| Phase 4 | NCT03701256 Comparator | Feb → Jul 2015 | — | University Tunis El Manar | Completed | No outcome recorded |
| Phase 4 | NCT02313337 Background | Dec 2014 → Dec 2015 | — | Second Affiliated Hospital of Xi'an Jiaotong University | Unknown | No outcome recorded |
| Phase 4 | NCT02289391 Background | Dec 2014 → Dec 2015 | asthma | Second Affiliated Hospital of Xi'an Jiaotong University | Unknown | No outcome recorded |
| Phase 4 | NCT02504138 Background | Jun 2014 → May 2017 | liver failure | Yonsei University | Completed | No outcome recorded |
| Phase 4 | NCT02544282 Comparator | Apr 2014 → Mar 2016 | — | GZA Ziekenhuizen Campus Sint-Augustinus | Completed | No outcome recorded |
| Phase 4 | NCT01870011 Comparator | Dec 2013 → Nov 2014 | end stage renal failure | Yonsei University | Completed | No outcome recorded |
| Phase 4 | NCT01631149 Comparator | Jun 2012 → Mar 2013 | benign prostatic hyperplasia, kidney disorder | Leiden University Medical Center | Completed | No outcome recorded |
| Phase 4 | NCT01097148 Comparator | Nov 2009 → Apr 2010 | obesity disorder | St. Antonius Hospital | Completed | No outcome recorded |
| — | NCT07824466 Comparator | Aug 2026 → Jul 2027 expected | — | Menoufia University | Recruiting | No outcome recorded |
| — | NCT05825430 Background | Apr → Jun 2023 | — | Al-Azhar University | Completed | No outcome recorded |
| — | NCT05632159 Comparator | Nov 2022 → Feb 2023 | — | Beni-Suef University | Unknown | No outcome recorded |
| — | NCT05481970 Comparator | Sep 2022 → Aug 2023 | — | Fayoum University Hospital | Completed | No outcome recorded |
| — | NCT05442905 Comparator | Aug 2022 → Mar 2023 | — | Tanta University | Unknown | No outcome recorded |
| — | NCT05241054 Comparator | Mar → Sep 2022 | lacrimal duct obstruction | Mansoura University | Unknown | No outcome recorded |
| — | NCT04945694 Background | Aug 2021 → Feb 2022 | congenital anomaly of cardiovascular system | Mansoura University | Unknown | No outcome recorded |
| — | NCT04614259 Background | Nov → Dec 2020 | — | Cairo University | Unknown | No outcome recorded |
| — | NCT04553536 Background | Nov 2020 → Jun 2023 | poisoning | Second Hospital of Shanxi Medical University | Unknown | No outcome recorded |
| — | NCT04344262 Comparator | Apr 2020 → Dec 2025 | — | Mansoura University | Unknown | No outcome recorded |
| — | NCT04095754 Background | Apr → Oct 2020 | — | Ain Shams University | Completed | No outcome recorded |
| — | NCT04078659 Background | Sep 2019 → Jan 2020 | — | Mansoura University | Unknown | No outcome recorded |
| — | NCT03803267 Comparator | May 2019 → Jan 2020 | colorectal cancer | Mansoura University | Completed | No outcome recorded |
| — | NCT04541732 Background | Jan → Apr 2019 | — | Mansoura University | Completed | No outcome recorded |
| — | NCT03569046 Comparator | Jul → Dec 2018 | — | Abd-Elazeem Abd-Elhameed Elbakry | Completed | No outcome recorded |
| — | NCT03666949 Background | May 2018 → Jan 2020 | — | University Hospital, Caen | Unknown | No outcome recorded |
| — | NCT03422354 Comparator | Feb → May 2018 | — | Cairo University | Completed | No outcome recorded |
| — | NCT03437213 Comparator | Jan 2018 → Aug 2019 | — | Alaa Mazy Mazy | Completed | No outcome recorded |
| — | NCT03005860 Background | Jan 2017 → Oct 2020 | breast cancer | Tata Memorial Centre | Withdrawn | No outcome recorded Stop: Business |
| — | NCT02768376 Comparator | Mar 2016 → Jun 2017 | gallbladder disorder | Mansoura University | Unknown | No outcome recorded |
| — | NCT02664142 Background | Jun 2015 → Sep 2017 | — | University Hospital Ostrava | Completed | No outcome recorded |
| — | NCT02505841 Background | May 2015 | — | University Hospital, Montpellier | Unknown | No outcome recorded |
| — | NCT02355678 Background | Jan → Aug 2015 | — | Makassed General Hospital | Completed | Missed primary |
| — | NCT02109133 Comparator | May → Dec 2014 | — | Yonsei University | Completed | No outcome recorded |
| — | NCT02174913 Comparator | May 2014 → Feb 2016 | vertebral column disorder | Mahidol University | Completed | No outcome recorded |
| — | NCT02169856 Background | Jul 2013 → Feb 2014 | — | Benazir Bhutto Hospital, Rawalpindi | Completed | No outcome recorded |
| — | NCT02162134 Background | Jan 2013 → Feb 2014 | ileus | Benazir Bhutto Hospital, Rawalpindi | Completed | No outcome recorded |
Evidence & citations 17 cited values
Every value below carries the sentence it was read from. 55 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Atracurium | “Subjects in the TH + NMB arm will be deeply sedated using agents at the discretion of the primary ICU team, then start continuous iv infusion of either cisatracurium,...” NCT03376854 ↗47“Subjects in the TH + NMB arm will be deeply sedated using agents at the discretion of the primary ICU team, then start continuous iv infusion of either cisatracurium,...” NCT04545424 ↗ “with fentanyl, (1mcg / kg), propofol (1-2 mg / kg), atracurium (0.5 mg / kg), intubation. Anesthesia maintained using Propofol (4-6) mg/kg/h, fentanyl (0.5-1) μg/kg/h. to be...” NCT03437213 ↗ “Induction will be done by fentanyl ( 2 mcg/kg ) , titrating dose of propofol according to patient hemodynamic response and atracurium ( 0.5 mg/kg ) to facilitate tracheal...” NCT05897151 ↗ “Desflurane balanced anesthesia induced with thiopental sodium, remifentanil and atracurium and maintained with remifentanil target controlled infusion and desflurane inhalation” NCT02504138 ↗ “Desflurane balanced anesthesia induced with thiopental sodium, remifentanil and atracurium and maintained with remifentanil target controlled infusion and desflurane inhalation” NCT01870011 ↗ “Use of a hypnotic("propofol 2.5mg/kg"), morphine("remifentanil1yg/kg") and curare("atracurium0.5mg/kg"), with the support of orotracheal intubation and mechanical ventilation” NCT03666949 ↗ “general anesthetic by midazolam 0.02 mg kg-1 , propofol 2-3 mg kg-1 and lidocaine 0.5 mg kg-1 , fentanyl 2 μg kg-1 , atracurium 0.5 mg kg-1 , isoflurane in 50% oxygen/air.” NCT03569046 ↗ “intubation will be facilitated by atracurium 0.5 mg/kg. Anaesthesia will be maintained by isoflurane 1.5 MAC and incremental doses of atracurium 0.15 mg/kg every 20 min” NCT05825430 ↗ “Anesthesia will be induced by propofol 1% (1-2 mg/kg), Fentanyl 1-2 mic/kg, and Atracurium 0.5 mg/kg then according to train of four response.” NCT02768376 ↗ “Induction of anesthesia will be done by injecting fentanyl 2 μg/kg, propofol1.5-2.5 mg/kg and atracurium 0.5 mg/kg for muscle relaxation.” NCT05632159 ↗ |
| Known as | Atracurium Besilate | “Propofol, Atracurium Besilate or Cisatracurium besylate or Rocuronium Bromide” NCT04553536 ↗ |
| Known as | Atracurium Besylate | ClinicalTrials.gov intervention name — accepted as the source's own label NCT05442905 ↗ |
| Known as | Atracurium besylate preservative free | ChEMBL registry synonym — accepted as the source's own label CHEMBL1360 ↗ |
| Known as | Atracurium cation | ChEMBL registry synonym — accepted as the source's own label CHEMBL1360 ↗ |
| Known as | Atracurium dibesylate | ChEMBL registry synonym — accepted as the source's own label CHEMBL1360 ↗ |
| Known as | Atracurium ion | ChEMBL registry synonym — accepted as the source's own label CHEMBL1360 ↗ |
| Known as | Besilate d'atracurium | ChEMBL registry synonym — accepted as the source's own label CHEMBL1360 ↗ |
| Known as | Besilato de atracurio | ChEMBL registry synonym — accepted as the source's own label CHEMBL1360 ↗ |
| Known as | BW 33A | ChEMBL registry synonym — accepted as the source's own label CHEMBL1360 ↗ |
| Known as | NSC-760047 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1360 ↗ |
| Known as | Tracrium | “intra-venous introduction: (Suphentanil: (0.1-0.3 ug/kg iv.), Propofol (2-2,5 mg/kg iv.), or Mivacron (0.15-2mg/kg ),Tracrium (0.3-0.6mg/kg)” NCT02664142 ↗ |
| Known as | Tracrium preservative free | ChEMBL registry synonym — accepted as the source's own label CHEMBL1360 ↗ |
| Known as | WELLCOME 33-A-74 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1360 ↗ |
| Action | Inhibit | “Current anesthesiologic practice during these procedures in the LUMC consists of an intravenous (propofol) or volatile (sevoflurane) anesthetic combined with mivacurium and...” NCT01631149 ↗ |
| Modality | Small molecule | — CHEMBL1360 ↗ |
| Route | Intravenous | “Atracurium (0.5 mg / kg IV)” NCT02036736 ↗ |