drugset / Trial / NCT05097508
Effect of Atracurium and Rocuronium on the State and Response Entropy During Isoflurane Anesthesia
RandomizedParallel-groupOpen-labelScreening
Summary
Many studies have explored the effects of inhalation anesthetics, intravenous anesthetics, and muscle relaxants on spectral entropy, but most did not monitor the degree of neuromuscular block. In addition, they do not explore the effects of different degrees of neuromuscular blockade on spectral entropy under different concentrations of isoflurane inhalation. Therefore, the present study will evaluate different levels of MAC to quantify the isoflurane concentration, as well as different degrees of neuromuscular blockade
Timeline
- Start
- 2020-06-20
- Primary completion
- 2021-06-20
- Completion
- 2021-10-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Atracurium | Small molecule | 0.005 mg/kg | Intravenous |
| Subject | Atracurium | Small molecule | 0.01 mg/kg | Intravenous |
| Subject | Rocuronium | Other / unclassified | 0.01 mg/kg | Intravenous |
| Subject | Rocuronium | Other / unclassified | 0.012 mg/kg | Intravenous |
Indications
No indication recorded.