Drugs / Rocuronium
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Rocuronium

Other / unclassified

Developed for
cardiac arrest · curariform drugs toxicity · acute respiratory distress syndrome · gallbladder disorder · newborn respiratory distress syndrome · pharyngitis · respiratory failure · appendicitis
+3 more · organophosphate poisoning · pediatric acute respiratory distress syndrome · urinary bladder cancer
Investigated by
Merck Sharp & Dohme LLC · Yonsei University · Seoul National University Hospital · Radboud University Medical Center · Seoul National University Bundang Hospital · Ain Shams University
+99 more · Asan Medical Center · Beth Israel Deaconess Medical Center · Brno University Hospital · Chonnam National University Hospital · Fondation Ophtalmologique Adolphe de Rothschild · Korea University Anam Hospital · Korea University Guro Hospital · Leiden University Medical Center · Massachusetts General Hospital · The Catholic University of Korea · The University of Texas Health Science Center, Houston · University Hospital Olomouc · University of Washington · AZ Sint-Jan AV · Air Force Military Medical University, China · Ajou University School of Medicine · Amsterdam UMC, location VUmc · Ankara City Hospital Bilkent · Azienda Ospedaliera di Padova · Bach Mai Hospital · Balgrist University Hospital · Beaumont Hospital · Brasilia University Hospital · Brigham and Women's Hospital · Central Hospital, Nancy, France · Centre Hospitalier Universitaire de la Réunion · Centro Hospitalar do Porto · Charles University, Czech Republic · Chulalongkorn University · Chun Song Youn · Clare Hayes-Bradley · Clinical Hospital Centre Zagreb · Federico II University · First Affiliated Hospital of Harbin Medical University · Fudan University · Gangnam Severance Hospital · General University Hospital, Prague · Go Eun Bae · Hanil General Hospital · Hanoi Medical University · Hanyang University Guri Hospital · Harbin Medical University · Hopital Foch · IGA - internal grant agency, Ministry of Health · IRCCS Azienda Ospedaliero-Universitaria di Bologna · Jaslok Hospital and Research Centre · Jiangsu HengRui Medicine Co., Ltd. · KDCHOT FN Brno · Kreiskrankenhaus Dormagen · MSD Belgium BVBA · MSD Korea Ltd. · Maharashtra University of Health Sciences · Malin Jonsson Fagerlund · Masaryk Hospital Usti nad Labem · Medical Center Haaglanden · Medical University of Bialystok · Medtronic - MITG · Memorial Sloan Kettering Cancer Center · Necker-Enfants Malades Hospital · Ostfold Hospital Trust · Palacky University · Peking Union Medical College Hospital · Peking University · Rigshospitalet, Denmark · SMG-SNU Boramae Medical Center · Sheba Medical Center · South Valley University · St. Anne's University Hospital Brno, Czech Republic · St. Vincent's Medical Center · Stony Brook University · São Paulo State University · TC Erciyes University · Taichung Armed Forces General Hospital · Tampere University Hospital · all 105 on the full record

Regulatory milestones approvals, filings & regulatory actions · 2 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Label expansion US (FDA) ZEMURON — 2008-08-28 fda.gov ↗
Approved US (FDA) ZEMURON — 1994-03-17 fda.gov ↗

Trials 115 · started per year

today
US approved 1994
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PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 02 trials
Phase 0 NCT05619848 Oct → Dec 2022 lumbar spinal stenosis Zheng Guo Completed No outcome recorded
Phase 0 NCT05097508 Jun 2020 → Jun 2021 — Ain Shams University Completed No outcome recorded
Phase 27 trials · 2 missed
Phase 2 NCT07252921 Oct → Dec 2025 — Jiangsu HengRui Medicine Co., Ltd. Completed No outcome recorded
Phase 2 NCT03808077 Jan 2019 → Oct 2024 overdue prostate cancer Memorial Sloan Kettering Cancer Center Active not recruiting No outcome recorded
Phase 2 NCT03532178 Jan 2019 → Mar 2022 — University of California, San Francisco Completed No outcome recorded
Phase 2 NCT02790164 May → Nov 2016 cardiac arrest Chun Song Youn Completed No outcome recorded
Phase 2 NCT02260258 Oct 2014 → May 2019 cardiac arrest Beth Israel Deaconess Medical Center Completed Missed primary
Phase 2 NCT01571908 Sep 2012 → Jul 2015 — University Hospital, Geneva Completed Missed primary
Phase 2 NCT03519867 Aug 2004 → May 2005 — Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 313 trials · 2 met primary · 1 missed
Phase 3 NCT05725031 Apr 2023 → Feb 2024 — Ain Shams University Completed No outcome recorded
Phase 3 NCT04709315 Oct 2020 → Jan 2021 — South Valley University Unknown No outcome recorded
Phase 3 NCT03043157 Feb → Mar 2017 — Brasilia University Hospital Completed No outcome recorded
Phase 3 NCT02000674 Dec 2013 → Jul 2016 — Centre Hospitalier Universitaire de la Réunion Completed Missed primary
Phase 3 NCT00656799 Apr 2008 → Jul 2009 — Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 3 NCT00559468 Dec 2006 → Mar 2007 — Merck Sharp & Dohme LLC Completed Met primary
Phase 3 NCT00474253 Feb → Aug 2006 — Merck Sharp & Dohme LLC Completed Met primary
Phase 3 NCT00421148 May 2005 → May 2006 — Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 3 NCT00124722 Dec 2004 → Jul 2007 — Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 3 NCT00124735 Oct 2004 → Aug 2007 — Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 441 trials · 7 met primary · 3 missed
Phase 4 NCT07650552 Sep 2026 → Aug 2028 expected apnea of prematurity, newborn respiratory distress syndrome, pulmonary immaturity UEA - Universidade Do Estado Do Amazonas Not yet recruiting No outcome recorded
Phase 4 NCT07168252 Dec 2025 → Dec 2026 expected — Clare Hayes-Bradley Not yet recruiting No outcome recorded
Phase 4 NCT06029049 Sep 2023 → Jun 2025 overdue — The University of Texas Health Science Center, Houston Recruiting No outcome recorded
Phase 4 NCT05562999 Nov 2022 → Aug 2024 — Radboud University Medical Center Completed Missed primary
Phase 4 NCT05509192 Aug 2022 → Jan 2025 — The University of Texas Health Science Center, Houston Completed No outcome recorded
Phase 4 NCT03643913 Dec 2018 → Nov 2024 arthropathy Universitaire Ziekenhuizen KU Leuven Completed No outcome recorded
Phase 4 NCT03608436 Oct 2018 → Mar 2021 — Radboud University Medical Center Completed No outcome recorded
Phase 4 NCT03572413 Oct 2018 → Aug 2020 — Radboud University Medical Center Completed No outcome recorded
Phase 4 NCT03646266 Aug 2018 → Dec 2020 respiratory failure Amsterdam UMC, location VUmc Unknown No outcome recorded
Phase 4 NCT03543826 May → Nov 2018 myopathy University of Washington Completed No outcome recorded
Phase not applicable52 trials · 2 met primary · 3 missed
— NCT07627750 Jun 2026 → Dec 2028 expected — Bach Mai Hospital Not yet recruiting No outcome recorded
— NCT07464288 Mar → Apr 2026 overdue — Ankara City Hospital Bilkent Not yet recruiting No outcome recorded
— NCT07035301 Mar → Jul 2025 respiratory system disorder Harbin Medical University Completed No outcome recorded
— NCT06553066 Aug 2024 → Aug 2026 overdue — University Hospital of Patras Not yet recruiting No outcome recorded
— NCT05909696 Jul → Oct 2023 curariform drugs toxicity Yangzhou University Completed No outcome recorded
— NCT05279898 Feb 2023 → Jun 2024 delirium Beth Israel Deaconess Medical Center Completed No outcome recorded
— NCT05453929 Sep 2021 → Dec 2024 vertebral column disorder Korea University Guro Hospital Completed No outcome recorded
— NCT04924621 Jun 2021 → May 2022 substance withdrawal syndrome Peking University Unknown No outcome recorded
— NCT04821817 Apr 2021 → Feb 2025 strabismus Tanta University Completed No outcome recorded
— NCT04768400 Mar 2021 → May 2022 brain neoplasm Gangnam Severance Hospital Completed No outcome recorded
Comparator or background therapy183 trials
Phase 0 NCT06720285 Background Oct → Nov 2023 — Universitas Airlangga Completed No outcome recorded
Phase 0 NCT05294926 Comparator Apr 2022 → Jan 2023 — Assiut University Unknown No outcome recorded
Phase 0 NCT04016740 Background Aug 2019 → Feb 2020 coronary artery disorder, delirium Beth Israel Deaconess Medical Center Completed No outcome recorded
Phase 1 NCT07603596 Background May 2026 → Apr 2028 expected delirium, digestive system neoplasm Qianfoshan Hospital Not yet recruiting No outcome recorded
Phase 1 NCT02888067 Comparator Jul 2017 → Jul 2022 — Thomas Schricker Terminated No outcome recorded Stop: Enrollment
Show all 183 trials opens the full record — a long page

News releases announcing trial results or a regulatory action · 1

DateIssuerRelease
2023-03-20 Lupin Limited Regulatory Lupin’s Alliance Partner Caplin Receives U.S. FDA Approval for Rocuronium Bromide Injection lupin.com ↗

Evidence & citations 19 cited values

Every value below carries the sentence it was read from. 301 sources stand behind the page.

FieldValueCited text
Known as Rocuronium “Rocuronium and cisatracurium are representative neuromuscular blocking agents used widely because the former have features of fast onset of peak effect and short duration of...” NCT02495038 ↗
269

“When participants reach the titration endpoint (OAAS score 1 point) during the titration of propofol in the induction, the investigators stop the dosing and switch to a...” NCT04595591 ↗

“Maintenance of anesthesia will be achieved by isoflurane at an end tidal concentration of 1-1.5% in FiO2 of 0.5, intravenous fentanyl at a dose of 1 µg/kg in incremental...” NCT06873906 ↗

“1-3 mg IV propofol 0.5 mg/kg IV Rocuronium + Fentanyl 2-3 mcg/kg + Morphine 0.1mg/kg IV Maintenance: Volatile anesthetic + High volume local anesthesia infiltration Bupivacaine...” NCT03176758 ↗

“The investigators therefore hypothesized that remifentanil could prolong the onset time of rocuronium, and evaluated the effect of remifentanil on the hemodynamic profiles...” NCT01030510 ↗

“Anesthetized patients (American Society of Anesthesiologists class 1-2) received 0.6 mg/kg rocuronium and were randomized to receive sugammadex (0.5, 1.0, 2.0, or 4.0 mg/kg) or...” PMID 19194156 ↗ Feb 2009

“Remimazolam 6mg/kg/h was pumped intravenously for 2.5 min, Sufentanil 0.5 μg/kg and rocuronium 0.6mg/kg were injected intravenously, and endotracheal intubation was performed 3...” NCT06775366 ↗

“Midazolam 0.03 mg/kg injection vein,Sufentanyl 0.5\~1 μg/kg, target controlled infusion of etomidate or propofol,after the consciousness of patients is lost, rocuronium...” NCT02644980 ↗

“Deep neuromuscular block will be induced by rocuronium bolus 1 mg/kg, maintained by a continuous infusion of rocuronium (0.6mg/kg/h), and titrated towards post-tetanic count (PTC) 1-2.” NCT04259112 ↗

“In addition to propofol as a hypnotic and rocuronium as a muscle relaxant, patients in the conventional opioid-based group will receive the following drugs: Remifentanil and Fentanyl” NCT05485480 ↗

“General anesthesia will be induced with fentanyl 1,5 mcg/kg, propofol 2 mg/kg, rocuronium 0,6 mg/kg; after intubation anesthesia will be mantained with sevoflurane (MAC 1).” NCT04294537 ↗

Show 259 more sources

Known as Bromure de rocuronium ChEMBL registry synonym — accepted as the source's own label CHEMBL1201244 ↗
Known as Bromuro de rocuronio ChEMBL registry synonym — accepted as the source's own label CHEMBL1201244 ↗
Known as Esmeron “Drug: Rocuronium Intravenous use: 0.3 mg/kg before intubation and 0,7 mg after intubation followed by infusion with 0,3-0,4 mg/kg/h Other Name: Esmeron” NCT01722097 ↗
8

“During the ablation performed, the patient will be under the influence of a muscle relaxant from the non-depolarising group (rocuronium, Esmeron®).” NCT06707532 ↗

“In this case the use of another neuromuscular blockade, Rocuronium (ESMERON), is an alternative solution.” NCT03960801 ↗

“rocuronium bromide (Zemuron®, Esmeron®)” NCT01564576 ↗

“0.6 mg/kg Rocuronium bromide (esmeron)” NCT06399445 ↗

“Rocuronium (Esmeron):” NCT01651572 ↗

NCT02790164 ↗

NCT00535743 ↗

NCT03519854 ↗

Known as Org 9426 “Rocuronium bromide (Org 9426)” NCT00984633 ↗
Known as ROC “This study aims to evaluate the influence of age and sepsis on in vivo activity of OATP1A2 using rocuronium (ROC) as a probe and evaluating the pharmacokinetics and...” NCT02399397 ↗
Known as Rocnium “Continuous Rocuronium (Rocnium®, Hanlim Pharm. Co., Ltd., South Korea) infusion during surgery” NCT03871387 ↗
Known as rocunium “Deep neuromuscular block with 'rocunium®'” NCT03937440 ↗
Known as Rocuronium Bromide “BACKGROUND: Succinylcholine remains the muscle relaxant of choice for rapid sequence induction (RSI) but has many adverse effects. High-dose rocuronium bromide may be an...” PMID 33337797 ↗ Dec 2021
33

“Induction of anesthesia will be the same for all patients and consist of intravenous anesthetic propofol (2-3 mg/kg), opioid analgesic fentanyl (1-1.5 mcg/kg), and muscle...” NCT05958589 ↗

“To achieve NMB, participants received steroidal NMBA Rocuronium Bromide or Vecuronium Bromide administered via i.v. infusion and dosed according to participant ABW.” NCT03346070 ↗

“participants received steroidal NMBA Rocuronium Bromide administered via IV infusion and dosed according to participant body weight.” NCT03346057 ↗

“Propofol, Atracurium Besilate or Cisatracurium besylate or Rocuronium Bromide” NCT04553536 ↗

“Rocuronium Bromide (Pretreatment Injection)” NCT07716891 ↗

“rocuronium bromide (Zemuron®, Esmeron®)” NCT01564576 ↗

“Rocuronium bromide” NCT04760912 ↗

“Rocuronium Bromide” NCT05687253 ↗

“Rocuronium bromide” NCT01142635 ↗

NCT00984633 ↗

Show 23 more sources

Known as Rocuronium bromide: Zemuron “Rocuronium bromide: Zemuron” NCT01450813 ↗
Known as Rocuronium cation ChEMBL registry synonym — accepted as the source's own label CHEMBL1201244 ↗
Known as Rocuronium Injectable Solution “Drug: Rocuronium Injectable Solution” NCT02953210 ↗
Known as Rocuronium ion ChEMBL registry synonym — accepted as the source's own label CHEMBL1201244 ↗
Known as rocuronium: Esmeron “rocuronium: Esmeron” NCT01748643 ↗
1

“Rocuronium, Esmeron” NCT02794714 ↗

Known as Zemuron “Rocuronium: Zemuron. Sugammadex: Bridion. Succinylcholine: Suxamethonium” NCT03532178 ↗
2

“rocuronium bromide (Zemuron®, Esmeron®)” NCT01564576 ↗

NCT03519867 ↗

Known as Zemuron Injection (rocuronium bromide) “Zemuron® Injection (rocuronium bromide)” NCT00751179 ↗
1

“Zemuron® Injection (rocuronium bromide)” NCT01728584 ↗

Action Inhibit “By binding free rocuronium, less rocuronium becomes available at the neuromuscular junction to bind to the muscarine receptor. Non-depolarizing neuromuscular blocking agents...” NCT01631149 ↗
Modality Other / unclassified “two commonly used neuromuscular blocking agents (succinylcholine and rocuronium)” NCT01441960 ↗
Route Intravenous “A single IV Zemuron bolus dose of 0.45 mg/kg prior to intubation.” NCT00124722 ↗