The Effect of Low Pressure Pneumoperitoneum During Laparoscopic Colorectal Surgery on Innate Immune Homeostasis.

Phase 4 Completed 100 enrolled Radboud University Medical Center Merck Sharp & Dohme LLC · collab

RandomizedParallel-groupTriple-blindTreatment

Summary

Substudy of the RECOVER trial (a randomised controlled trial comparing the effect of low pressure pneumoperitoneum with deep neuromuscular block versus normal pressure pneumoperitoneum with moderate neuromuscular block during laparoscopic colorectal surgery on early quality of recovery) investigating innate immune homeostasis after laparoscopic colorectal surgery.

Timeline

Start: 2018-10-24
Primary completion: 2020-08-31
Completion: 2020-12-01

Publications

Albers-Warle KI, Helder LS, Groh LA, Polat F, Panhuizen IF, Snoeck MMJ, Kox M, van Eijk L, Joosten LAB, Netea MG, Negishi Y, Mhlanga M, Keijzer C, Scheffer GJ, Warle MC. Postoperative Innate Immune Dysregulation, Proteomic, and Monocyte Epigenomic Changes After Colorectal Surgery: A Substudy of a Randomized Controlled Trial. Anesth Analg. 2025 Jan 1;140(1):185-196. doi: 10.1213/ANE.0000000000007297. Epub 2024 Oct 25.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Rocuronium	Other / unclassified	—	—

Indications

No indication recorded.