drugset / Trial / NCT04924621
Sedation Compaired With Anesthesia With THRIVE in Endotracheal Intubation With Difficult Airways
RandomizedParallel-groupDouble-blindTreatment
Summary
To compare the difference in endotracheal intubation in participants with difficult airway between under general anesthesia by Transnasal Humidified Rapid-Insufflation Ventilatory Exchange and under traditional sedation by mask ventilation. The investigators focus on the different outcomes in oxygenation maintaince, carbon dioxide removal and the effectiveness of safety apnea time, to evaluate the safety of receiving endotracheal intubation under general anesthesia in participants with difficult airway.
Timeline
- Start
- 2021-06-10
- Primary completion
- 2022-05-10
- Completion
- 2022-06-10
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Propofol | Small molecule | 1 ug/ml | Intravenous |
| Subject | Propofol | Small molecule | 2 ug/ml | Intravenous |
| Subject | Propofol | Small molecule | 3 ug/ml | Intravenous |
| Subject | Rocuronium | Other / unclassified | 0.06 mg/kg | Intravenous |
| Comparator | Sufentanil | Other / unclassified | 0.02 ug/kg | Intravenous |
| Comparator | Sufentanil | Other / unclassified | 0.05 ug/kg | Intravenous |
| Comparator | Sufentanil | Other / unclassified | 5 ug | Intravenous |
| Background | Midazolam | Small molecule | 0.05 mg/kg | Intravenous |
| Comparator | tetracaine | Other / unclassified | 2 ml | — |