Effects of Depth of Neuromuscular Block on Surgical Operating Conditions in Gynecologic Laparoscopic Surgery

Completed 50 enrolled Federico II University

RandomizedParallel-groupSingle-blindSupportive care

Summary

Comparison of the impact of a deep neuromuscular blockade (TOF count = 0 and posttetanic count \[PTC\] 1-2) and a moderate neuromuscular blockade (TOF count= 1 - 3) on intraoperative surgical conditions assessed by the surgeon as a 5 points scale (Optimal= 5 points/ Good= 4 points / Adequate= 3 points / Poor = 2 points / Inadequate = 1 point) in patients undergoing laparosopy for benign gynecological pathologies.

Timeline

Start: 2020-02-01
Primary completion: 2020-07-01
Completion: 2020-07-31

Outcome

Met primary endpoint

paper The average score for the operative field was 4 for the D-NMB group and 3 for the M-NMB group (p value < 0.01). PMID 37386582 ↗

Publications

Coviello A, Ianniello M, Buonanno P, Di Falco N, Iacovazzo C, Maresca A, Vargas M, Marra A, Candice A, Saccone G, Zullo F, Servillo G. Effects of depth of neuromuscular block on surgical operating conditions in women undergoing gynecologic laparoscopic surgery: a randomized clinical trial. J Anesth Analg Crit Care. 2023 Jan 19;3(1):2. doi: 10.1186/s44158-023-00086-7.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Rocuronium	Other / unclassified	0.15 mg/kg	Intravenous
Subject	Rocuronium	Other / unclassified	0.25 mg/kg	Intravenous
Subject	Rocuronium	Other / unclassified	0.3 mg/kg	Intravenous
Subject	Rocuronium	Other / unclassified	0.6 mg/kg	Intravenous

Indications

No indication recorded.