drugset / Trial / NCT02054468
Rocuronium Dose Finding Study After Single-shot or Steady-state Propofol Anesthesia
RandomizedParallel-groupOpen-labelTreatment
Summary
This study is designed to determine the effective-doses ED-50 and ED-95 (the doses required for a 50% and 95% twitch inhibition, respectively) of the non-depolarizing muscle relaxant rocuronium after single-shot or steady-state propofol anesthesia in a clinical setting.
Timeline
- Start
- 2012-03
- Primary completion
- 2014-02
- Completion
- 2014-02
Publications
- Background Naguib M, Seraj M, Abdulrazik E. Pipecuronium-induced neuromuscular blockade during nitrous oxide-fentanyl, enflurane, isoflurane, and halothane anesthesia in surgical patients. Anesth Analg. 1992 Aug;75(2):193-7. doi: 10.1213/00000539-199208000-00007.
- Background Viby-Mogensen J, Jorgensen BC, Ording H. Residual curarization in the recovery room. Anesthesiology. 1979 Jun;50(6):539-41. doi: 10.1097/00000542-197906000-00014. No abstract available.
- Background Debaene B, Plaud B, Dilly MP, Donati F. Residual paralysis in the PACU after a single intubating dose of nondepolarizing muscle relaxant with an intermediate duration of action. Anesthesiology. 2003 May;98(5):1042-8. doi: 10.1097/00000542-200305000-00004.
- Background Eikermann M, Blobner M, Groeben H, Rex C, Grote T, Neuhauser M, Beiderlinden M, Peters J. Postoperative upper airway obstruction after recovery of the train of four ratio of the adductor pollicis muscle from neuromuscular blockade. Anesth Analg. 2006 Mar;102(3):937-42. doi: 10.1213/01.ane.0000195233.80166.14.
- Background Hemmerling TM, Le N, Decarie P, Cousineau J, Bracco D. Total intravenous anesthesia with propofol augments the potency of mivacurium. Can J Anaesth. 2008 Jun;55(6):351-7. doi: 10.1007/BF03021490.
- Background Robertson EN, Fragen RJ, Booij LH, van Egmond J, Crul JF. Some effects of diisopropyl phenol (ICI 35 868) on the pharmacodynamics of atracurium and vecuronium in anaesthetized man. Br J Anaesth. 1983 Aug;55(8):723-8. doi: 10.1093/bja/55.8.723.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Propofol | Small molecule | 1.5 mg/kg | Intravenous |
| Comparator | Propofol | Small molecule | 2.5 mg/kg | Intravenous |
| Comparator | Propofol | Small molecule | 4 mg/kg | Intravenous |
| Comparator | Propofol | Small molecule | 6 mg/kg | Intravenous |
| Subject | Rocuronium | Other / unclassified | 0.07 mg/kg | — |
| Subject | Rocuronium | Other / unclassified | 0.1 mg/kg | — |
| Subject | Rocuronium | Other / unclassified | 0.15 mg/kg | — |
| Subject | Rocuronium | Other / unclassified | 0.2 mg/kg | — |
| Subject | Rocuronium | Other / unclassified | 0.3 mg/kg | — |
| Subject | Rocuronium | Other / unclassified | 0.45 mg/kg | — |
| Background | Remifentanil | Small molecule | 0.1 ug/kg | — |
| Background | Remifentanil | Small molecule | 0.2 ug/kg | — |
Indications
No indication recorded.