Effectiveness of Deep Versus Moderate Neuromuscular Blockade

Completed 100 enrolled Asan Medical Center

RandomizedParallel-groupDouble-blindTreatment

Summary

The aim of this study is to evaluate the influence of depth of neuromuscular blockade during laparoscopic gastrectomy on postoperative pain in surgical patients allocated randomly to either deep or moderate neuromuscular blockade group with standard-pressure pneumoperitoneum of 13 mmHg.

Timeline

Start: 2018-03-28
Primary completion: 2018-11-01
Completion: 2018-11-02

Outcome

Missed primary endpoint

paper Deep, compared with moderate, NMB did not significantly reduce the MEAD of oxycodone administered in the PACU. PMID 31503037 ↗

Publications

Choi BM, Ki SH, Lee YH, Gong CS, Kim HS, Lee IS, Kim BS, Kim BS, Noh GJ. Effects of depth of neuromuscular block on postoperative pain during laparoscopic gastrectomy: A randomised controlled trial. Eur J Anaesthesiol. 2019 Nov;36(11):863-870. doi: 10.1097/EJA.0000000000001082.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Rocuronium	Other / unclassified	0.2 mg/kg	Intravenous
Subject	Rocuronium	Other / unclassified	0.6 mg/kg	Intravenous
Subject	Rocuronium	Other / unclassified	0.8 mg/kg	Intravenous
Subject	Rocuronium	Other / unclassified	1.2 mg/kg	Intravenous

Indications

No indication recorded.