drugset / Trial / NCT05562999
Impact of Deep Neuromuscular Blockade During Total Hip Replacement Surgery on Postoperative Recovery and Immune Function
RandomizedParallel-groupDouble-blindTreatment
Summary
Monocenter randomized controlled trial to compare the effect of deep neuromuscular blockade (NMB) versus moderate NMB during total hip replacement surgery on postoperative quality of recovery and innate immune function.
Timeline
- Start
- 2022-11-18
- Primary completion
- 2024-08-29
- Completion
- 2024-08-29
Publications
- Bijkerk V, Jacobs LMC, Rijnen WHC, Keijzer C, Warle MC, Visser J. Deep versus Moderate Neuromuscular Blockade During Total Hip Replacement Surgery on Postoperative Recovery and Immune Function: A Randomized Controlled Trial. Anesth Analg. 2026 Feb 1;142(2):355-364. doi: 10.1213/ANE.0000000000007639. Epub 2025 Jul 17.
- Jacobs LMC, Bijkerk V, van Eijk LT, Joosten LAB, Keijzer C, Visser J, Warle MC. The effect of general versus spinal anesthesia on perioperative innate immune function in patients undergoing total hip arthroplasty. BMC Anesthesiol. 2025 Jan 7;25(1):10. doi: 10.1186/s12871-024-02883-1.
- Bijkerk V, Visser J, Jacobs LMC, Keijzer C, Warle MC. Deep versus moderate neuromuscular blockade during total hip arthroplasty to improve postoperative quality of recovery and immune function: protocol for a randomised controlled study. BMJ Open. 2023 Aug 28;13(8):e073537. doi: 10.1136/bmjopen-2023-073537.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Rocuronium | Other / unclassified | — | — |
Indications
No indication recorded.