Impact of Deep Neuromuscular Blockade During Total Hip Replacement Surgery on Postoperative Recovery and Immune Function

Summary

Monocenter randomized controlled trial to compare the effect of deep neuromuscular blockade (NMB) versus moderate NMB during total hip replacement surgery on postoperative quality of recovery and innate immune function.

Timeline

Start

2022-11-18

Primary completion

2024-08-29

Completion

2024-08-29

Outcome

Missed primary endpoint

paper There was no difference in QoR-40 score on POD1 (mean difference -4.1, 95% confidence interval -10.9 to 2.8, P = .241). PMID 40674253 ↗

Publications

• Bijkerk V, Jacobs LMC, Rijnen WHC, Keijzer C, Warle MC, Visser J. Deep versus Moderate Neuromuscular Blockade During Total Hip Replacement Surgery on Postoperative Recovery and Immune Function: A Randomized Controlled Trial. Anesth Analg. 2026 Feb 1;142(2):355-364. doi: 10.1213/ANE.0000000000007639. Epub 2025 Jul 17.
• Jacobs LMC, Bijkerk V, van Eijk LT, Joosten LAB, Keijzer C, Visser J, Warle MC. The effect of general versus spinal anesthesia on perioperative innate immune function in patients undergoing total hip arthroplasty. BMC Anesthesiol. 2025 Jan 7;25(1):10. doi: 10.1186/s12871-024-02883-1.
• Bijkerk V, Visser J, Jacobs LMC, Keijzer C, Warle MC. Deep versus moderate neuromuscular blockade during total hip arthroplasty to improve postoperative quality of recovery and immune function: protocol for a randomised controlled study. BMJ Open. 2023 Aug 28;13(8):e073537. doi: 10.1136/bmjopen-2023-073537.

Drugs

Indications

No indication recorded.