drugset / Trial / NCT01930747
Effect of Deep Neuromuscular Block (NMB), Inhalation or TIVA on Pneumoperitoneum.
RandomizedParallel-groupTriple-blindTreatment
Summary
The objective of this study is to compare the value of deep neuromuscular block (NMB) (using rocuronium) in laparoscopy versus high dose opioids (using remifentanil) or 1 minimum alveolar concentration (MAC) inhalation (using sevoflurane) for the surgeon. The study hypothesis is that laparoscopic workspace is larger when using rocuronium versus opioids or inhalation. Laparoscopic workspace is measured as the abdominal compliance and the pressure at volume zero (PV0) using the abdominal pressure volume relation. Three points allow to calculate the abdominal compliance and the pressure at zero volume (PV0).
Timeline
- Start
- 2013-04
- Primary completion
- 2015-12
- Completion
- 2016-04
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Remifentanil | Small molecule | 10 ug/kg | Intravenous |
| Subject | Remifentanil | Small molecule | 50 ug/kg | Intravenous |
| Subject | Rocuronium | Other / unclassified | 1 mg/kg | Intravenous |
| Subject | Sevoflurane | Other / unclassified | 1 unknown | Inhaled |
Indications
No indication recorded.