Rapid Sequence Intubation With Magnesium-rocuronium Compared With Succinylcholine - A Randomised Clinical Study

NCT01571908 ↗

Phase 2 Completed 280 enrolled University Hospital, Geneva University of Lausanne Hospitals · collab

RandomizedParallel-groupQuadruple-blindTreatment

Summary

Magnesium accelerates the reaction of rocuronium, a neuromuscular blocker used for muscle relaxation to ease the intubation during anaesthesia. Succinylcholine is a very fast reacting neuromuscular blocker. It is often used in emergency procedures, when rapid intubation is necessary. We want to now if a perfusion of magnesium before anaesthesia accelerates to such an extent the reaction of rocuronium that intubation conditions are comparable or even better than with succinylcholine alone (prior perfusion of saline=placebo)

Timeline

Start: 2012-09
Primary completion: 2015-07
Completion: 2015-07

Publications

Czarnetzki C, Albrecht E, Masouye P, Baeriswyl M, Poncet A, Robin M, Kern C, Tramer MR. Rapid Sequence Induction With a Standard Intubation Dose of Rocuronium After Magnesium Pretreatment Compared With Succinylcholine: A Randomized Clinical Trial. Anesth Analg. 2021 Dec 1;133(6):1540-1549. doi: 10.1213/ANE.0000000000005324.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Magnesium Sulfate	Other / unclassified	60 mg/kg	Intravenous
Subject	Rocuronium	Other / unclassified	0.6 mg/kg	Intravenous
Comparator	Suxamethonium	Other / unclassified	1 mg/kg	Intravenous

Indications

No indication recorded.