Normobaric Oxygen (NBO) Therapy in Acute Migraine

Summary

This is a pilot study investigating the therapeutic potential of breathing 100% oxygen in acute migraine headache.

Timeline

Start

2012-07

Primary completion

2015-09

Completion

2015-09

Outcome

Missed primary endpoint

paper mean decrease in pain score from baseline to 30 minutes) was 1.38 ± 1.42 in oxygen-treated and 1.22 ± 1.61 in air-treated attacks ( p = 0.674). PMID 27206964 ↗

Publications

• Results Singhal AB, Maas MB, Goldstein JN, Mills BB, Chen DW, Ayata C, Kacmarek RM, Topcuoglu MA. High-flow oxygen therapy for treatment of acute migraine: A randomized crossover trial. Cephalalgia. 2017 Jul;37(8):730-736. doi: 10.1177/0333102416651453. Epub 2016 May 20.

Drugs

Indications