Heliox-Driven Racemic Epinephrine in Treatment of Bronchiolitis in Pediatric ED Patients

Phase 3 Completed 72 enrolled University of Louisville

RandomizedParallel-groupTriple-blindTreatment

Summary

The purpose of this study is to assess whether children with moderate to severe bronchiolitis treated with standard racemic epinephrine therapy via 70:30 helium-oxygen (heliox) driven nebulization will have improvements in measurements of airway more rapidly than those treated with conventional air-oxygen driven nebulization.

Timeline

Start: 2004-12
Primary completion: 2008-03
Completion: 2011-10

Outcome

Met primary endpoint

paper was 1.84 for the helium-oxygen group compared with 0.31 for the oxygen group (P < .001). PMID 22147778 ↗

paper was associated with a greater degree of clinical improvement compared with that delivered by oxygen among infants with bronchiolitis. PMID 22147778 ↗

Publications

Results Kim IK, Phrampus E, Sikes K, Pendleton J, Saville A, Corcoran T, Gracely E, Venkataraman S. Helium-oxygen therapy for infants with bronchiolitis: a randomized controlled trial. Arch Pediatr Adolesc Med. 2011 Dec;165(12):1115-22. doi: 10.1001/archpediatrics.2011.605.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Heliox	Other / unclassified	—	Inhaled
Subject	Oxygen	Other / unclassified	—	Inhaled