drugset / Trial / NCT00547209
Effect of Nitrous Oxide on Intravenous Closed-loop Anesthesia
RandomizedParallel-groupSingle-blindTreatment
Summary
The main objective of the study is to analyze the influence of nitrous oxide on propofol and remifentanil requirements.
Timeline
- Start
- 2007-10
- Primary completion
- 2009-11
- Completion
- 2009-11
Publications
- Background Liu N, Chazot T, Genty A, Landais A, Restoux A, McGee K, Laloe PA, Trillat B, Barvais L, Fischler M. Titration of propofol for anesthetic induction and maintenance guided by the bispectral index: closed-loop versus manual control: a prospective, randomized, multicenter study. Anesthesiology. 2006 Apr;104(4):686-95. doi: 10.1097/00000542-200604000-00012.
- Background Karalapillai D, Leslie K, Umranikar A, Bjorksten AR. Nitrous oxide and anesthetic requirement for loss of response to command during propofol anesthesia. Anesth Analg. 2006 Apr;102(4):1088-93. doi: 10.1213/01.ane.0000198672.05639.0a.
- Liu N, Le Guen M, Boichut N, Genty A, Herail T, Schmartz D, Khefif G, Landais A, Bussac JJ, Charmeau A, Baars J, Rehberg B, Tricoche S, Chazot T, Sessler DI, Fischler M. Nitrous oxide does not produce a clinically important sparing effect during closed-loop delivered propofol-remifentanil anaesthesia guided by the bispectral index: a randomized multicentre study. Br J Anaesth. 2014 May;112(5):842-51. doi: 10.1093/bja/aet479. Epub 2014 Jan 31.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Nitrous Oxide | Other / unclassified | 60 % | Inhaled |
| Background | Oxygen | Other / unclassified | 40 % | Inhaled |
Indications
No indication recorded.