Supplemental Oxygen in Hypovolemia

Summary

Supplemental oxygen is frequently administered in acutely and critically ill patients, specifically, it is often administered in trauma patients to avoid arterial hypoxemia and tissue hypoxia. There is also an increasing focus on potentially deleterious effects of hyperoxia. Further, the hemodynamic response to hyperoxia in hypovolemia is poorly understood. The present study aims to investigate the effects of supplemental oxygen on systemic and cerebral hemodynamics in simulated hypovolemia in healthy volunteers.

Timeline

Start

2021-11-26

Primary completion

2022-06-14

Completion

2022-06-14

Outcome

Missed primary endpoint

paper Oxygen had no statistically significant effect on the changes in cardiac output (0.031 L/min/LBNP level, 95% confidence interval (CI): - 0.015 to 0.077, P = 0.188). PMID 37947905 ↗

Publications

• Lie SL, Hisdal J, Rehn M, Hoiseth LO. Hemodynamic effects of supplemental oxygen versus air in simulated blood loss in healthy volunteers: a randomized, controlled, double-blind, crossover trial. Intensive Care Med Exp. 2023 Nov 10;11(1):76. doi: 10.1186/s40635-023-00561-z.

Drugs

Indications