Effect of Hyperoxemia on Platelet Function in Healthy Volunteers

Summary

Prospective, controlled, randomized crossover volunteer study to investigate the effect of hyperoxemia due to inhalation of oxygen (80% inspiratory fraction) via reservoir-face-mask on blood coagulation, especially platelet function, as measured by thrombelastography. According to results of basic animal and in vitro investigations, hyperoxemia may activate platelets by means of reactive oxygen species. This study aims at investigating a possible pro-coagulant effect of hyperoxemia in healthy volunteers. Additional studies on possible mechanisms are integrated. * Trial with medical device

Timeline

Start

2009-04

Primary completion

2010-03

Completion

2010-05

Drugs

Indications

No indication recorded.