drugset
drugset / Trial / NCT02206178

Acetaminophen's Antinociceptive Effect When Associated With N-Acetylcysteneine

NCT02206178 ↗

Phase 1 Completed 24 enrolled University Hospital, Clermont-Ferrand
RandomizedCrossoverDouble-blindTreatment

Summary

Acetaminophen is one of the most widely used analgesic in the world, recommended for the symptomatic treatment of fever and pain. The purpose of this study is to assess the effectiveness of acetaminophen in association with N-acetylcysteine. The objective of this study is to evaluate if the association in healthy volunteers of acetaminophen and N-acétylcystéine 1. \- decrease the antinociceptive effect of acetaminophen in comparison to a group control 2. \- and if this antinociceptive effect may depend of the genetic polymorphism of GSH enzyme.

Timeline

Start
2013-09
Primary completion
2014-01
Completion
2014-01

Drugs

EvaluationDrugModalityDoseRoute
Subject Acetaminophen Small molecule — Oral
Subject N-acetylcysteine Small molecule — Oral

Indications

No indication recorded.