drugset / Trial / NCT01214083

N-acetylcysteine Plus Naltrexone for the Treatment of Alcohol Dependence

NCT01214083

Phase 2 Completed 111 enrolled VA Office of Research and Development
RandomizedParallel-groupQuadruple-blindTreatment

Summary

The purpose of this study is to determine whether: (1) the combination of N-acetylcysteine + high-dose naltrexone (150 mg) works better than high-dose naltrexone (150 mg) alone in reducing alcohol drinking; and (2) high-dose naltrexone (150 mg) alone works better than low-dose naltrexone (50 mg) alone in reducing alcohol drinking.

Timeline

Start
2010-10-15
Primary completion
2015-09-30
Completion
2016-10-30

Drugs

EvaluationDrugModalityDoseRoute
Subject N-acetylcysteine Small molecule
Subject Naltrexone Small molecule 50 mg
Subject Naltrexone Small molecule 150 mg

Indications