drugset / Trial / NCT00353340
Prevention of Contrast Nephropathy by Sodium Bicarbonate Versus Sodium Chloride and N-acetylcysteine
RandomizedParallel-groupDouble-blindPrevention
Summary
The objective of this study is to assess the efficacy of sodium bicarbonate compared with sodium chloride and oral N-acetylcysteine (NAC ) pretreatment for prevention of contrast nephropathy in patients with advanced renal disease undergoing cardiac catheterisation.
Timeline
- Start
- 2005-01
- Primary completion
- 2008-01
- Completion
- 2009-05
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | N-acetylcysteine | Small molecule | 600 mg | Oral |
| Subject | sodium bicarbonate | Diagnostic / imaging agent | 154 meq | Intravenous |
| Subject | sodium chloride | Unknown | 154 meq | — |