Acetylcysteine in the Prevention of Renal Failure After Bypass Surgery

Summary

The purpose of this study is to determine if Acetylcysteine is effective in preventing renal failure associated with cardiac surgery

Timeline

Start

2003-04

Primary completion

—

Completion

2006-11

Outcome

Missed primary endpoint

paper CONCLUSION: Prophylactic perioperative NAC administration does not prevent AKI after cardiac surgery. PMID 18513531 ↗

Publications

• Adabag AS, Ishani A, Koneswaran S, Johnson DJ, Kelly RF, Ward HB, McFalls EO, Bloomfield HE, Chandrashekhar Y. Utility of N-acetylcysteine to prevent acute kidney injury after cardiac surgery: a randomized controlled trial. Am Heart J. 2008 Jun;155(6):1143-9. doi: 10.1016/j.ahj.2008.01.013. Epub 2008 Mar 5.

Drugs

Indications